Works (6)

Updated: July 5th, 2023 15:57

2007 article

Physiologically based pharmacokinetic modeling

VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, pp. 42–50.

By: D. Merwe, J. Buur* & J. Riviere*

TL;DR: Physiologically based pharmacokinetic (PBPK) models are mathematical simulations of physiological processes that determine the rate and extent of xenobiotic chemical absorption, distribution, metabolism, and excretion that can be used for predicting internal doses at target organs and tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A physiologically based pharmacokinetic model of organophosphate dermal absorption

TOXICOLOGICAL SCIENCES, 89(1), 188–204.

author keywords: dermal absorption; PBPK model; parathion; fenthion; methyl parathion
MeSH headings : Administration, Cutaneous; Animals; Dose-Response Relationship, Drug; Fenthion / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Methyl Parathion / pharmacokinetics; Models, Biological; Organothiophosphorus Compounds / pharmacokinetics; Parathion / pharmacokinetics; Risk Assessment; Skin / metabolism; Skin Absorption / physiology; Skin Physiological Phenomena; Solubility; Swine
TL;DR: The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin

SKIN PHARMACOLOGY AND PHYSIOLOGY, 19(4), 198–206.

author keywords: hierarchical clustering; K-means clustering; skin permeability; stratum corneum partitioning
MeSH headings : Animals; Cluster Analysis; Dermis / metabolism; Epidermis / metabolism; Female; In Vitro Techniques; Permeability; Skin Absorption; Skin Physiological Phenomena; Solubility; Solvents / chemistry; Swine
TL;DR: The consistent influence of the inclusion of propylene glycol in the solvent system supports the hypothesis that over-saturation due to solvent evaporation has a marked effect on permeability, and the potential of using cluster analysis of large datasets to identify consistent solvent and chemical mixture effects is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Ethnoveterinary medicine practices among Tsonga speaking people of South Africa

Onderstepoort Journal of Veterinary Research, 73(2), 115–122.

By: D. Luseba & D. Van Der Merwe

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane

TOXICOLOGY IN VITRO, 19(1), 69–77.

author keywords: dermal absorption; partitioning; chemical mixtures
MeSH headings : Animals; Epidermis / drug effects; Epidermis / metabolism; Ethanol / pharmacology; Membranes, Artificial; Permeability / drug effects; Silicone Elastomers; Skin Absorption / drug effects; Skin Absorption / physiology; Solubility / drug effects; Solvents / pharmacology; Spectroscopy, Fourier Transform Infrared; Swine / physiology; Water / pharmacology; Xenobiotics / metabolism
TL;DR: These studies suggest that stratum corneum partitioning of the compounds tested is primarily determined by relative compound solubility between the stratum Corneum lipids and the donor solvent. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle

AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(1), 108–112.

MeSH headings : Ampicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / pharmacokinetics; Cattle / metabolism; Cluster Analysis; Multivariate Analysis
TL;DR: Meta-analysis was successful in detecting a potential subpopulation of cattle for which factors that explained differences in pharmacokinetic parameters could be identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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