Amber K. Goetz
Works (6)
Updated: July 5th, 2023 15:50
2009 journal article
Inhibition of Rat and Human Steroidogenesis by Triazole Antifungals
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE, 55(5-6), 214–226.
author keywords: CYP17; myclobutanil; propiconazole; testosterone; triadimefon
MeSH headings : Animals; Antifungal Agents / pharmacology; Cell Line, Tumor; Humans; Male; Nitriles / pharmacology; Organ Culture Techniques; Rats; Rats, Wistar; Steroid 17-alpha-Hydroxylase / metabolism; Steroids / biosynthesis; Testosterone / biosynthesis; Triazoles / pharmacology
TL;DR:
Data indicate that myclobutanil, propiconazole, and triadimefon are weak inhibitors of testosterone production in vitro, however, in vivo exposure of rats to triazoles resulted in increased serum and intra-testicular testosterone levels.
(via Semantic Scholar)
www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals
TOXICOLOGICAL SCIENCES, 110(2), 449–462.
author keywords: myclobutanil; propiconazole; triadimefon; toxicogenomics; steroid metabolism
MeSH headings : Aging; Animals; Antifungal Agents / toxicity; Chemical and Drug Induced Liver Injury; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Gestational Age; Infertility, Male / chemically induced; Infertility, Male / genetics; Infertility, Male / metabolism; Liver / drug effects; Liver / metabolism; Liver Diseases / genetics; Liver Diseases / metabolism; Male; Nitriles / toxicity; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Reproduction / drug effects; Reproduction / genetics; Testis / drug effects; Testis / metabolism; Testosterone / genetics; Testosterone / metabolism; Triazoles / toxicity
TL;DR:
These relatively high dose and long-term exposures to triazole antifungals appeared to perturb fatty acid and steroid metabolism in the male rat liver predominantly through the CAR and PXR signaling pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Toxicogenomic effects common to triazole antifungals and conserved between rats and humans
TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(1), 80–89.
author keywords: Myclobutanil; Propiconazole; Triadimefon; Toxicogenomics; CAR; PXR
MeSH headings : Animals; Antifungal Agents / administration & dosage; Antifungal Agents / toxicity; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation / drug effects; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Liver / drug effects; Liver / metabolism; Male; Nitriles / administration & dosage; Nitriles / toxicity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Time Factors; Toxicogenetics; Triazoles / administration & dosage; Triazoles / toxicity
TL;DR:
Gene expression changes caused by all three triazoles in liver and hepatocytes were concentrated in biological pathways regulating lipid, sterol and steroid homeostasis, identifying a potential common mode of action conserved between rodents and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat
Toxicological Sciences, 95(1), 227–239.
MeSH headings : Anal Canal / drug effects; Anal Canal / growth & development; Animals; Antifungal Agents / toxicity; Body Weight / drug effects; Cell Shape / drug effects; Dose-Response Relationship, Drug; Eating / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Genitalia, Male / pathology; Homeostasis / drug effects; Liver / drug effects; Liver / pathology; Male; Nitriles / toxicity; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reproduction / drug effects; Sexual Maturation / drug effects; Sperm Motility / drug effects; Spermatozoa / drug effects; Spermatozoa / pathology; Testosterone / blood; Time Factors; Triazoles / toxicity
TL;DR:
Insemination and fertility were impaired by myclobutanil and triadimefon treatment, consistent with the disruption of testosterone homeostasis as a key event in the mode of action for triazole-induced reproductive toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Effect of conazole fungicides on reproductive development in the female rat
Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
A database for tracking toxicogenomic samples and procedures
Reproductive Toxicology (Elmsford, N.Y.), 19(3), 411–419.
Source: NC State University Libraries
Added: August 6, 2018
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