Amber K. Goetz

Works (6)

Updated: July 5th, 2023 15:50

2009 journal article

Inhibition of Rat and Human Steroidogenesis by Triazole Antifungals

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE, 55(5-6), 214–226.

By: A. Goetz*, J. Rockett*, H. Ren*, I. Thillainadarajah* & D. Dix*

author keywords: CYP17; myclobutanil; propiconazole; testosterone; triadimefon
MeSH headings : Animals; Antifungal Agents / pharmacology; Cell Line, Tumor; Humans; Male; Nitriles / pharmacology; Organ Culture Techniques; Rats; Rats, Wistar; Steroid 17-alpha-Hydroxylase / metabolism; Steroids / biosynthesis; Testosterone / biosynthesis; Triazoles / pharmacology
TL;DR: Data indicate that myclobutanil, propiconazole, and triadimefon are weak inhibitors of testosterone production in vitro, however, in vivo exposure of rats to triazoles resulted in increased serum and intra-testicular testosterone levels. (via Semantic Scholar)
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Added: August 6, 2018

2009 journal article

Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals

TOXICOLOGICAL SCIENCES, 110(2), 449–462.

By: A. Goetz n & D. Dix*

author keywords: myclobutanil; propiconazole; triadimefon; toxicogenomics; steroid metabolism
MeSH headings : Aging; Animals; Antifungal Agents / toxicity; Chemical and Drug Induced Liver Injury; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Gestational Age; Infertility, Male / chemically induced; Infertility, Male / genetics; Infertility, Male / metabolism; Liver / drug effects; Liver / metabolism; Liver Diseases / genetics; Liver Diseases / metabolism; Male; Nitriles / toxicity; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Reproduction / drug effects; Reproduction / genetics; Testis / drug effects; Testis / metabolism; Testosterone / genetics; Testosterone / metabolism; Triazoles / toxicity
TL;DR: These relatively high dose and long-term exposures to triazole antifungals appeared to perturb fatty acid and steroid metabolism in the male rat liver predominantly through the CAR and PXR signaling pathways. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans

TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(1), 80–89.

By: A. Goetz n & D. Dix*

author keywords: Myclobutanil; Propiconazole; Triadimefon; Toxicogenomics; CAR; PXR
MeSH headings : Animals; Antifungal Agents / administration & dosage; Antifungal Agents / toxicity; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation / drug effects; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Liver / drug effects; Liver / metabolism; Male; Nitriles / administration & dosage; Nitriles / toxicity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Time Factors; Toxicogenetics; Triazoles / administration & dosage; Triazoles / toxicity
TL;DR: Gene expression changes caused by all three triazoles in liver and hepatocytes were concentrated in biological pathways regulating lipid, sterol and steroid homeostasis, identifying a potential common mode of action conserved between rodents and humans. (via Semantic Scholar)
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Added: August 6, 2018

2007 journal article

Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat

Toxicological Sciences, 95(1), 227–239.

By: A. Goetz n, H. Ren*, J. Schmid*, C. Blystone n, I. Thillainadarajah*, D. Best*, H. Nichols*, L. Strader* ...

MeSH headings : Anal Canal / drug effects; Anal Canal / growth & development; Animals; Antifungal Agents / toxicity; Body Weight / drug effects; Cell Shape / drug effects; Dose-Response Relationship, Drug; Eating / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Genitalia, Male / pathology; Homeostasis / drug effects; Liver / drug effects; Liver / pathology; Male; Nitriles / toxicity; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reproduction / drug effects; Sexual Maturation / drug effects; Sperm Motility / drug effects; Spermatozoa / drug effects; Spermatozoa / pathology; Testosterone / blood; Time Factors; Triazoles / toxicity
TL;DR: Insemination and fertility were impaired by myclobutanil and triadimefon treatment, consistent with the disruption of testosterone homeostasis as a key event in the mode of action for triazole-induced reproductive toxicity. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Effect of conazole fungicides on reproductive development in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.

By: J. Rockett, M. Narotsky, K. Thompson, I. Thillainadarajah, C. Blystone, A. Goetz, H. Ren, D. Best ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

A database for tracking toxicogenomic samples and procedures

Reproductive Toxicology (Elmsford, N.Y.), 19(3), 411–419.

By: W. Bao, J. Schmid, A. Goetz, H. Ren & D. Dix

Source: NC State University Libraries
Added: August 6, 2018

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