Jeffrey E. Edwards
Works (1)
Updated: July 5th, 2023 15:57
2005 journal article
Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 49(4), 1626–1628.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism; Acridines / pharmacology; Animals; Animals, Newborn; Blood-Brain Barrier / metabolism; Female; HIV Protease Inhibitors / blood; HIV Protease Inhibitors / pharmacokinetics; Lactation; Mammary Glands, Animal / metabolism; Milk / metabolism; Nelfinavir / blood; Nelfinavir / pharmacokinetics; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines / pharmacology
TL;DR:
Western blotting indicated that P-glycoprotein is expressed in rat mammary and brain tissue; however, the multidrug-resistant modulator GF120918 showed a significant effect only at the blood-brain barrier and not at the mammary-epithelial tissue barrier.
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aac.asm.org (publisher PDF)
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3. Good Health and Well-being
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Added: August 6, 2018
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