@article{zou_zeng_2009, title={Multiple interval mapping for gene expression QTL analysis}, volume={137}, ISSN={["1573-6857"]}, DOI={10.1007/s10709-009-9365-z}, abstractNote={To find the correlations between genome-wide gene expression variations and sequence polymorphisms in inbred cross populations, we developed a statistical method to claim expression quantitative trait loci (eQTL) in a genome. The method is based on multiple interval mapping (MIM), a model selection procedure, and uses false discovery rate (FDR) to measure the statistical significance of the large number of eQTL. We compared our method with a similar procedure proposed by Storey et al. and found that our method can be more powerful. We identified the features in the two methods that resulted in different statistical powers for eQTL detection, and confirmed them by simulation. We organized our computational procedure in an R package which can estimate FDR for positive findings from similar model selection procedures. The R package, MIM-eQTL, can be found at http://www.statgen.ncsu.edu/~wzou/MIM.eQTL.html .}, number={2}, journal={GENETICA}, author={Zou, Wei and Zeng, Zhao-Bang}, year={2009}, month={Nov}, pages={125–134} } @article{lai_leips_zou_roberts_wollenberg_parnell_zeng_ordovas_mackay_2007, title={Speed-mapping quantitative trait loci using microarrays}, volume={4}, ISSN={["1548-7105"]}, DOI={10.1038/NMETH1084}, abstractNote={We developed a rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples. We generated 21,207 F2 flies from two inbred Drosophila melanogaster strains with known QTLs affecting lifespan, and hybridized DNA pools of young and old flies to microarrays. We used changes of gene frequency of 2,326 single-feature polymorphisms (SFPs) to map previously identified and additional QTLs affecting lifespan.}, number={10}, journal={NATURE METHODS}, author={Lai, Chao-Qiang and Leips, Jeff and Zou, Wei and Roberts, Jessica F. and Wollenberg, Kurt R. and Parnell, Laurence D. and Zeng, Zhao-Bang and Ordovas, Jose M. and Mackay, Trudy F. C.}, year={2007}, month={Oct}, pages={839–841} } @article{zou_aylor_zeng_2007, title={eQTL Viewer: visualizing how sequence variation affects genome-wide transcription}, volume={8}, number={7}, journal={BMC Bioinformatics}, author={Zou, W. and Aylor, D. L. and Zeng, Z. B.}, year={2007} } @article{zeng_wang_zou_2005, title={Modeling quantitative trait loci and interpretation of models}, volume={169}, ISSN={["0016-6731"]}, DOI={10.1534/genetics.104.035857}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Zeng, ZB and Wang, T and Zou, W}, year={2005}, month={Mar}, pages={1711–1725} }