Ralph L. House

Works (4)

Updated: July 5th, 2023 15:57

2009 journal article

Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 21(9), 848–855.

By: M. Ashwell  n, R. Ceddia n, R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n 

Contributors: M. Ashwell  n, R. Ceddia n, R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n 

author keywords: Gene expression; Mice; Liver, Conjugated linoleic acid; Obesity, Hepatic steatosis, Fatty liver
MeSH headings : Animals; Fatty Liver / genetics; Fatty Liver / metabolism; Gene Expression Profiling; Hepatocyte Nuclear Factor 4 / genetics; Linoleic Acids, Conjugated / pharmacology; Liver / metabolism; Male; Mice; Obesity / genetics; Obesity / metabolism
TL;DR: While surprisingly few genes in lipid metabolism were impacted, pathway analysis found that protein kinase A and cyclic adenosine monophosphate pathways signaling pathways were affected by CLA treatment and 98 of the 775 genes were found to be regulated by hepatocyte nuclear factor 4alpha, a transcription factor important in controlling liver metabolic status. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2005 review

Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue

[Review of ]. OBESITY REVIEWS, 6(3), 247–258.

By: R. House n, J. Cassady n, E. Eisen n, M. McIntosh* & J. Odle n 

Contributors: R. House n, J. Cassady n, E. Eisen n, M. McIntosh* & J. Odle n 

author keywords: adipocyte; adipose tissue; CLA; de-lipidation; lipid metabolism; liver tissue; obesity
MeSH headings : Adipose Tissue / metabolism; Animals; Cattle; Energy Metabolism / drug effects; Gene Expression Regulation / drug effects; Humans; Linoleic Acids, Conjugated / pharmacology; Lipid Metabolism; Liver / metabolism; Mice; Obesity / genetics; Obesity / metabolism; Organ Size / drug effects; Rats
TL;DR: Recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism are examined, specifically focused on changes in gene expression and physiology of liver and adipose tissue. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice

PHYSIOLOGICAL GENOMICS, 21(3), 351–361.

By: R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n 

Contributors: R. House n, J. Cassady n, E. Eisen n, T. Eling*, J. Collins*, S. Grissom*, J. Odle n 

author keywords: apoptosis; cell biology; gene expression; lipid metabolism; obesity
MeSH headings : Animals; Base Sequence; Body Weight / drug effects; DNA Primers; Gene Expression Regulation / drug effects; Genomics; Lipids / physiology; Male; Mice; Mice, Inbred ICR; Mice, Obese; Obesity / drug therapy; Obesity / genetics; Oligonucleotide Array Sequence Analysis; Organ Size / drug effects; Reverse Transcriptase Polymerase Chain Reaction; alpha-Linolenic Acid / analogs & derivatives; alpha-Linolenic Acid / therapeutic use
TL;DR: It was concluded that, in adipose tissue, CLA increased expression of uncoupling proteins (1 and 2), carnitine palmitoyltransferase system, tumor necrosis factor-alpha, and caspase-3 but decreased expression of peroxisome proliferator-activated receptor-gamma, glucose transporter-4, perilipin, caveolin-1, adiponectin, resistin, and Bcl-2. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Ontogeny and kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of the domestic felid ()

The Journal of Nutritional Biochemistry, 16(6), 331–338.

By: X. Lin n, R. House n & J. Odle n 

Contributors: X. Lin n, R. House n & J. Odle n 

author keywords: fatty acid oxidation; feline development; lipid metabolism; cats; CPT
MeSH headings : Animals; Carnitine / analogs & derivatives; Carnitine / metabolism; Carnitine O-Palmitoyltransferase / biosynthesis; Carnitine O-Palmitoyltransferase / metabolism; Cats / growth & development; Cats / metabolism; Kinetics; Liver / enzymology; Liver / growth & development; Muscle, Skeletal / enzymology; Muscle, Skeletal / growth & development
TL;DR: It is concluded that postnatal increases in CPT activity support increased capacity for fatty acid oxidation in the developing felid and that dietary carnitine may be required to maximize enzyme activity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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