Yang Shen

Works (3)

Updated: July 5th, 2023 15:57

2019 article

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Menden, M. P., Wang, D., Mason, M. J., Szalai, B., Bulusu, K. C., Guan, Y., … Fourches, D. (2019, June 17). Nature Communications.

By: M. Menden *, D. Wang *, M. Mason *, B. Szalai *, K. Bulusu *, Y. Guan *, T. Yu *, J. Kang * ...

MeSH headings : ADAM17 Protein / antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Benchmarking; Biomarkers, Tumor / genetics; Cell Line, Tumor; Computational Biology / methods; Computational Biology / standards; Datasets as Topic; Drug Antagonism; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Drug Synergism; Genomics / methods; Humans; Molecular Targeted Therapy / methods; Mutation; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics / methods; Pharmacogenetics / standards; Phosphatidylinositol 3-Kinases / genetics; Phosphoinositide-3 Kinase Inhibitors; Treatment Outcome
topics (OpenAlex): Computational Drug Discovery Methods; Bioinformatics and Genomic Networks; Protein Degradation and Inhibitors
TL;DR: A large drug combination screen across cancer cell lines is provided to benchmark crowdsourced methods and to computationally predict drug synergies, and genomic rationale for synergy predictions are identified. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019

2005 article

Artificial neural network modeling of peptide mobility and peptide mapping in capillary zone electrophoresis

Jalali-Heravi, M., Shen, Y., Hassanisadi, M., & Khaledi, M. G. (2005, October 11). Journal of Chromatography A.

By: M. Jalali-Heravi n, Y. Shen n, M. Hassanisadi * & M. Khaledi n

author keywords: peptide mapping; capillary zone electrophoresis; electrophoretic mobility; artificial neural networks
MeSH headings : Amino Acid Sequence; Cytochromes c / chemistry; Electrophoresis, Capillary / methods; Glucagon / chemistry; Molecular Sequence Data; Multivariate Analysis; Neural Networks, Computer; Oligopeptides / isolation & purification; Peptide Fragments / chemistry; Peptide Mapping / methods; Regression Analysis
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Spectroscopy Techniques in Biomedical and Chemical Research; Microfluidic and Capillary Electrophoresis Applications
TL;DR: The present model exhibits better robustness than the MLR models in predicting CZE mobilities of a diverse data set at different experimental conditions and indicates the non-linear characteristics of the electrophoretic mobility of peptides. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Prediction of electrophoretic mobilities of peptides in capillary zone electrophoresis by quantitative structure‐mobility relationships using the offord model and artificial neural networks

Jalali‐Heravi, M., Shen, Y., Hassanisadi, M., & Khaledi, M. G. (2005, April 11). Electrophoresis.

By: M. Jalali‐Heravi n, Y. Shen n, M. Hassanisadi n & M. Khaledi n

author keywords: artificial neural networks; capillary zone electrophoresis; electrophoretic mobility; peptide separation and mapping; structure-mobility relationship
MeSH headings : Electrophoresis, Capillary / methods; Neural Networks, Computer; Peptides / chemistry; Peptides / isolation & purification; Regression Analysis; Reproducibility of Results; Structure-Activity Relationship
topics (OpenAlex): Microfluidic and Capillary Electrophoresis Applications; Analytical Chemistry and Chromatography; Biosensors and Analytical Detection
TL;DR: A 3–4–1 back propagation artificial neural networks (BP‐ANN) model resulted in a significant improvement in the predictive ability of the QSMR over the MLR treatment, especially for peptides of higher charges that contain basic amino acids arginine, histidine, and lysine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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