Jennifer L. Buur

Works (7)

Updated: July 5th, 2023 15:57

2008 article

Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model

Buur, J. L., Baynes, R. E., & Riviere, J. E. (2008, May 21). Regulatory Toxicology and Pharmacology, Vol. 51, pp. 324–331.

By: J. Buur n, R. Baynes n  & J. Riviere n

author keywords: PBPK; melamine; rat; porcine; meat withdrawal time; feed contaminants
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Drug Administration Schedule; Drug Residues / analysis; Food Contamination / prevention & control; Male; Meat Products; Models, Biological; Rats; Rats, Inbred F344; Reproducibility of Results; Resins, Synthetic / pharmacokinetics; Swine; Time Factors; Triazines / pharmacokinetics
topics (OpenAlex): Melamine detection and toxicity; Mercury impact and mitigation studies; Dye analysis and toxicity
TL;DR: A physiologically based pharmacokinetic model for melamine was developed for rats and extrapolated to pigs, providing evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Sulfamethazine Water Medication Pharmacokinetics and Contamination in a Commercial Pig Production Unit

Mason, S. E., Baynes, R. E., Buur, J. L., Riviere, J. E., & Almond, G. W. (2008, March 1). Journal of Food Protection, Vol. 71, pp. 584–589.

By: S. Mason n, R. Baynes n , J. Buur n, J. Riviere n & G. Almond n 

MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Consumer Product Safety; Dose-Response Relationship, Drug; Drug Residues / analysis; Food Contamination / analysis; Half-Life; Humans; Metabolic Clearance Rate; Pilot Projects; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Water / chemistry
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pharmaceutical and Antibiotic Environmental Impacts; Analytical Methods in Pharmaceuticals; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: Plasma levels in pigs treated with an oral bolus, which is equivalent to the total drug consumed within a 24-h period, achieved therapeutic concentrations and noncompartmental-based pharmacokinetic model parameters were consistent with previously published values in swine. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Physiologically based pharmacokinetic modeling

Merwe, D., Buur, J. L., & Riviere, J. E. (2007, January 1). Elsevier EBooks.

By: D. Merwe*, J. Buur* & J. Riviere*

topics (OpenAlex): Advancements in Transdermal Drug Delivery; Drug Solubulity and Delivery Systems; Antibiotics Pharmacokinetics and Efficacy
TL;DR: Physiologically based pharmacokinetic (PBPK) models are mathematical simulations of physiological processes that determine the rate and extent of xenobiotic chemical absorption, distribution, metabolism, and excretion that can be used for predicting internal doses at target organs and tissues. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Pharmacokinetics of flunixin meglumine in swine after intravenous dosing

BUUR, J. L., BAYNES, R. E., SMITH, G., & RIVIERE, J. E. (2006, September 6). Journal of Veterinary Pharmacology and Therapeutics, Vol. 29, pp. 437–440.

By: J. Buur n, R. Baynes n , G. Smith n  & J. Riviere n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / metabolism; Clonixin / pharmacokinetics; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Protein Binding; Swine
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Analytical Chemistry and Chromatography; Drug Transport and Resistance Mechanisms
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Use of Probabilistic Modeling within a Physiologically BasedPharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine

Buur, J., Baynes, R., Smith, G., & Riviere, J. (2006, June 26). Antimicrobial Agents and Chemotherapy, Vol. 50, pp. 2344–2351.

By: J. Buur n, R. Baynes n , G. Smith n  & J. Riviere n

MeSH headings : Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Female; Legislation, Drug; Legislation, Veterinary; Meat; Models, Statistical; Monte Carlo Method; Predictive Value of Tests; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Time Factors; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pharmaceutical and Antibiotic Environmental Impacts; Pesticide Residue Analysis and Safety
TL;DR: Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues

Buur, J. L., Baynes, R. E., Craigmill, A. L., & Riviere, J. E. (2005, October 1). American Journal of Veterinary Research, Vol. 66, pp. 1686–1693.

By: J. Buur n, R. Baynes* , A. Craigmill & J. Riviere*

MeSH headings : Adipose Tissue / metabolism; Animals; Injections, Intravenous / veterinary; Kidney / metabolism; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Sulfamethazine / administration & dosage; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism; Tissue Distribution
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pesticide Residue Analysis and Safety; Pharmacological Effects and Assays
TL;DR: Use of this model enabled accurate prediction of sulfamethazine pharmacokinetics in swine and has applications for food safety and prediction of drug residues in edible tissues. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Analysis of diltiazem in Lipoderm® transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies

Buur, J. L., Baynes, R. E., Yeatts, J. L., Davidson, G., & DeFrancesco, T. C. (2004, December 29). Journal of Pharmaceutical and Biomedical Analysis.

By: J. Buur n, R. Baynes n , J. Yeatts n, G. Davidson n & T. DeFrancesco n 

author keywords: diltiazem; reverse-phase liquid chromatography; transdermal gel; drug stability; compounded drug analysis
MeSH headings : Calcium Channel Blockers / analysis; Chromatography, High Pressure Liquid / methods; Diltiazem / analysis; Drug Stability; Gels; Pharmaceutical Preparations / chemistry; Reference Standards; Reproducibility of Results
topics (OpenAlex): Analytical Methods in Pharmaceuticals; Advancements in Transdermal Drug Delivery; Pesticide Residue Analysis and Safety
TL;DR: A simple and novel method for the extraction and quantification of diltiazem hydrochloride was developed and applied to homogenization and stability studies and showed excellent linearity from 50 to 250 mg/ml in undiluted gel. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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