Jennifer L. Buur
Works (7)
Updated: July 5th, 2023 15:57
2008 journal article
Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 51(3), 324–331.
author keywords: PBPK; melamine; rat; porcine; meat withdrawal time; feed contaminants
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Drug Administration Schedule; Drug Residues / analysis; Food Contamination / prevention & control; Male; Meat Products; Models, Biological; Rats; Rats, Inbred F344; Reproducibility of Results; Resins, Synthetic / pharmacokinetics; Swine; Time Factors; Triazines / pharmacokinetics
TL;DR:
A physiologically based pharmacokinetic model for melamine was developed for rats and extrapolated to pigs, providing evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit
JOURNAL OF FOOD PROTECTION, 71(3), 584–589.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Consumer Product Safety; Dose-Response Relationship, Drug; Drug Residues / analysis; Food Contamination / analysis; Half-Life; Humans; Metabolic Clearance Rate; Pilot Projects; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Water / chemistry
TL;DR:
Plasma levels in pigs treated with an oral bolus, which is equivalent to the total drug consumed within a 24-h period, achieved therapeutic concentrations and noncompartmental-based pharmacokinetic model parameters were consistent with previously published values in swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 article
Physiologically based pharmacokinetic modeling
VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, pp. 42–50.
TL;DR:
Physiologically based pharmacokinetic (PBPK) models are mathematical simulations of physiological processes that determine the rate and extent of xenobiotic chemical absorption, distribution, metabolism, and excretion that can be used for predicting internal doses at target organs and tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Pharmacokinetics of flunixin meglumine in swine after intravenous dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(5), 437–440.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / metabolism; Clonixin / pharmacokinetics; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Protein Binding; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(7), 2344–2351.
MeSH headings : Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Female; Legislation, Drug; Legislation, Veterinary; Meat; Models, Statistical; Monte Carlo Method; Predictive Value of Tests; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Time Factors; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA.
(via Semantic Scholar)
open access via aac.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(10), 1686–1693.
MeSH headings : Adipose Tissue / metabolism; Animals; Injections, Intravenous / veterinary; Kidney / metabolism; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Sulfamethazine / administration & dosage; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism; Tissue Distribution
TL;DR:
Use of this model enabled accurate prediction of sulfamethazine pharmacokinetics in swine and has applications for food safety and prediction of drug residues in edible tissues.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Analysis of diltiazem in Lipoderm (R) transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 38(1), 60–65.
author keywords: diltiazem; reverse-phase liquid chromatography; transdermal gel; drug stability; compounded drug analysis
MeSH headings : Calcium Channel Blockers / analysis; Chromatography, High Pressure Liquid / methods; Diltiazem / analysis; Drug Stability; Gels; Pharmaceutical Preparations / chemistry; Reference Standards; Reproducibility of Results
TL;DR:
A simple and novel method for the extraction and quantification of diltiazem hydrochloride was developed and applied to homogenization and stability studies and showed excellent linearity from 50 to 250 mg/ml in undiluted gel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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