@article{hodgson_wallace_shah_choi_joo_2014, title={Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations}, volume={28}, ISSN={["1099-0461"]}, DOI={10.1002/jbt.21534}, abstractNote={ABSTRACT}, number={1}, journal={JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}, author={Hodgson, Ernest and Wallace, Andrew D. and Shah, Ruchir R. and Choi, Kyoungju and Joo, Hyun}, year={2014}, month={Jan}, pages={1–10} } @article{joo_choi_hodgson_2010, title={Human metabolism of atrazine}, volume={98}, ISSN={["1095-9939"]}, DOI={10.1016/j.pestbp.2010.05.002}, abstractNote={Atrazine (ATZ) metabolism by human liver microsomes (HLM), cytochrome P450 (CYP) isoforms, and human liver (HL) S9 fractions, was investigated using HPLC/PDA and LC/MS/MS. CYP-dependent metabolites from pooled HLM are desethylatrazine (DEA), desisopropylatrazine (DIA), 1-hydroxyisopropylatrazine (HIATZ), and 2-hydroxyethyl atrazine (HEATZ). DEA and DIA were major metabolites in pooled HLM. CYP1A2 and 2C19, respectively, were major isoforms for DEA and DIA production. CYP3A4, while less active, is generally at high concentrations, produces both DEA and DIA and is significant. The percent total normalized rates (%TNR) for CYP1A2 and 3A4 in pooled HLM were 63% and 24% for DEA, and 35% and 56% for DIA production. Single donor HLM samples, showed correlations for CYP1A2 (r = 0.92) and 3A4 (r = 0.81) for DEA and DIA production, while variations in production of DEA and DIA were 8.5- and 6.0-fold, respectively. Pooled S9 fractions also mediate glutathione conjugation of atrazine, DEA and DIA.}, number={1}, journal={PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY}, author={Joo, Hyun and Choi, Kyoungju and Hodgson, Ernest}, year={2010}, month={Sep}, pages={73–79} } @article{white_potter_bosch_joo_schaffer_munoz-carpena_2009, title={Reduction in Metolachlor and Degradate Concentrations in Shallow Groundwater through Cover Crop Use}, volume={57}, ISSN={["1520-5118"]}, DOI={10.1021/jf9021527}, abstractNote={Pesticide use during crop production has the potential to adversely impact groundwater quality. In southern Florida, climatic and hydrogeologic conditions and agronomic practices indicate that contamination risks are high. In the current study, dissipation of the widely used herbicide, metolachlor, and levels of the compound and selected degradates in shallow groundwater beneath six 0.15-ha plots in sweet corn (Zea mays) production were evaluated over a two-year period. During fallow periods (May to October), plots were either left bare or cover cropped with sunn hemp (Crotalaria juncea L.). Metolachlor was broadcast applied at label recommended rates prior to planting sweet corn each year. Groundwater monitoring wells hydraulically upgradient and downgradient, and within each plot were sampled biweekly. Results showed that metolachlor dissipation was rapid, as evidenced by the detection of relatively high levels of the metolachlor ethane sulfonic degradate (MESA) in groundwater beneath plots and a rapid metolachlor DT(50) (9-14 days) in a companion laboratory soil incubation. Other degradates detected included hydroxymetolachlor in soil and in groundwater metolachlor oxanilic acid (MOA) and a product tentatively identified as 2-chloro-N-(2-acetyl-6-methylphenyl-N-(2-methoxy-1-methylethyl) acetamide, a photo-oxidation product. Metolachlor and MESA levels, up to 16 and 2.4 times higher in groundwater beneath the noncover cropped plots when compared to those of the cover cropped plots, indicate that cover cropping results in more rapid dissipation and/or reduced leaching. The study demonstrated that integration of cover crops into agronomic systems in the region may yield water quality benefits by reducing herbicide inputs to groundwater.}, number={20}, journal={JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY}, author={White, Paul M. and Potter, Thomas L. and Bosch, David D. and Joo, Hyun and Schaffer, Bruce and Munoz-Carpena, Rafael}, year={2009}, month={Oct}, pages={9658–9667} } @article{joo_choi_rose_hodgson_2007, title={Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos}, volume={21}, ISSN={["1095-6670"]}, DOI={10.1002/jbt.20161}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}, author={Joo, Hyun and Choi, Kyoungju and Rose, Randy L. and Hodgson, Ernest}, year={2007}, pages={76–80} } @article{potter_bosch_joo_schaffer_munoz-carpena_2007, title={Summer cover crops reduce atrazine leaching to shallow groundwater in southern Florida}, volume={36}, ISSN={["0047-2425"]}, DOI={10.2134/jeq2006.0526}, abstractNote={Abstract}, number={5}, journal={JOURNAL OF ENVIRONMENTAL QUALITY}, author={Potter, Thomas L. and Bosch, David D. and Joo, Hyun and Schaffer, Bruce and Munoz-Carpena, Rafael}, year={2007}, pages={1301–1309} } @article{choi_joo_rose_hodgson_2006, title={Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes}, volume={20}, DOI={10.1002/jbt.20145}, abstractNote={Abstract}, number={6}, journal={Journal of Biochemical and Molecular Toxicology}, author={Choi, K. and Joo, H. and Rose, R. L. and Hodgson, E.}, year={2006}, pages={279–291} } @article{potter_strickland_joo_culbreath_2005, title={Accelerated soil dissipation of tebuconazole following multiple applications to peanut}, volume={34}, ISSN={["0047-2425"]}, DOI={10.2134/jeq2004.0473}, abstractNote={ABSTRACT}, number={4}, journal={JOURNAL OF ENVIRONMENTAL QUALITY}, author={Potter, TL and Strickland, TC and Joo, H and Culbreath, AK}, year={2005}, pages={1205–1213} }