Works (2)

Updated: July 5th, 2023 15:56

2006 journal article

Evidence against calcium as a mediator of mitochondrial dysfunction during apoptosis induced by arachidonic acid and other free fatty acids

JOURNAL OF IMMUNOLOGY, 177(9), 6398–6404.

By: R. Maia n, C. Culver n & S. Laster n

MeSH headings : Animals; Apoptosis; Arachidonic Acid / pharmacology; Autocrine Communication; Calcium / metabolism; Cell Line; Fatty Acids, Nonesterified / pharmacology; Fibroblasts / drug effects; Fibroblasts / metabolism; Membrane Potential, Mitochondrial / drug effects; Mice; Mitochondria / drug effects; Mitochondria / metabolism
TL;DR: It is found that cyclosporine A could inhibit the AA-induced loss of Δψm with both whole cells and isolated mitochondria, confirming that the antimitochondrial effects of FFA can stem from direct effects on the mitochondrial permeability transition pore. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

The anti-apoptotic effects of nordihydroguaiaretic acid: Inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling

LIFE SCIENCES, 77(19), 2457–2470.

By: C. Culver*, S. Michalowski*, R. Maia* & S. Laster*

author keywords: apoptosis; NDGA; cPLA(2)
MeSH headings : Animals; Antioxidants / pharmacology; Apoptosis / drug effects; Arachidonic Acid / metabolism; Blotting, Western; Butylated Hydroxyanisole / pharmacology; Calcium Signaling / drug effects; Caspases / metabolism; Cell Line; Chromium Radioisotopes; Enzyme Activation / drug effects; Fibroblasts / drug effects; Fibroblasts / metabolism; Immunoprecipitation; Male; Masoprocol / pharmacology; Mice; Microscopy, Phase-Contrast; Phosphates / metabolism; Phospholipases A / antagonists & inhibitors; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The mechanism underlying the ability of NDGA to inhibit TNF-induced apoptosis is examined and it is shown that NDGA blocks many key indicators of apoptosis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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