Works (4)

Updated: July 5th, 2023 15:56

2008 journal article

Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(12), 7338–7345.

By: D. Barua n, J. Faeder* & J. Haugh n

MeSH headings : Animals; Humans; Kinetics; Models, Biological; Phosphatidylinositol 3-Kinases / chemistry; Phosphatidylinositol 3-Kinases / metabolism; Receptor, Platelet-Derived Growth Factor beta / chemistry; Receptor, Platelet-Derived Growth Factor beta / metabolism; Surface Plasmon Resonance / methods; src Homology Domains / physiology
TL;DR: To analyze the interactions between tandem SH2 domains and bisphosphorylated peptides, detailed kinetic models were formulated and applied to the phosphoinositide 3-kinase p85 regulatory subunit/platelet- derived growth factor β-receptor system and found homodimerization of full-length p85 was found to be an alternative mechanism for high avidity binding to phosphorylated platelet-derived growth factor receptors. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Structure-based kinetic models of modular signaling protein function: Focus on Shp2

BIOPHYSICAL JOURNAL, 92(7), 2290–2300.

By: D. Barua n, J. Faeder* & J. Haugh n

MeSH headings : Computer Simulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins / chemistry; Intracellular Signaling Peptides and Proteins / metabolism; Kinetics; Models, Biological; Models, Chemical; Models, Molecular; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases / chemistry; Protein Tyrosine Phosphatases / metabolism; Protein Tyrosine Phosphatases / ultrastructure; SH2 Domain-Containing Protein Tyrosine Phosphatases; Structure-Activity Relationship
TL;DR: To the knowledge, this is the first kinetic model to fully consider the modular, multifunctional structure of a signaling protein, and the computational approach should be generally applicable to other complex intermolecular interactions. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Supercritical-carbon dioxide-assisted cyclic deposition of metal oxide and metal thin films

APPLIED PHYSICS LETTERS, 88(9).

By: D. Barua n, T. Gougousi n, E. Young n & G. Parsons n

Contributors: D. Barua n, T. Gougousi n, E. Young n & G. Parsons n

Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Metal oxide thin films deposited from metal organic precursors in supercritical CO2 solutions

CHEMISTRY OF MATERIALS, 17(20), 5093–5100.

By: T. Gougousi n, D. Barua n, E. Young n & G. Parsons n

Contributors: T. Gougousi n, D. Barua n, E. Young n & G. Parsons n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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