Works (4)
Updated: July 5th, 2023 15:56
2008 journal article
Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(12), 7338–7345.
MeSH headings : Animals; Humans; Kinetics; Models, Biological; Phosphatidylinositol 3-Kinases / chemistry; Phosphatidylinositol 3-Kinases / metabolism; Receptor, Platelet-Derived Growth Factor beta / chemistry; Receptor, Platelet-Derived Growth Factor beta / metabolism; Surface Plasmon Resonance / methods; src Homology Domains / physiology
TL;DR:
To analyze the interactions between tandem SH2 domains and bisphosphorylated peptides, detailed kinetic models were formulated and applied to the phosphoinositide 3-kinase p85 regulatory subunit/platelet- derived growth factor β-receptor system and found homodimerization of full-length p85 was found to be an alternative mechanism for high avidity binding to phosphorylated platelet-derived growth factor receptors.
(via Semantic Scholar)
open access via www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Structure-based kinetic models of modular signaling protein function: Focus on Shp2
BIOPHYSICAL JOURNAL, 92(7), 2290–2300.
MeSH headings : Computer Simulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins / chemistry; Intracellular Signaling Peptides and Proteins / metabolism; Kinetics; Models, Biological; Models, Chemical; Models, Molecular; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases / chemistry; Protein Tyrosine Phosphatases / metabolism; Protein Tyrosine Phosphatases / ultrastructure; SH2 Domain-Containing Protein Tyrosine Phosphatases; Structure-Activity Relationship
TL;DR:
To the knowledge, this is the first kinetic model to fully consider the modular, multifunctional structure of a signaling protein, and the computational approach should be generally applicable to other complex intermolecular interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Supercritical-carbon dioxide-assisted cyclic deposition of metal oxide and metal thin films
APPLIED PHYSICS LETTERS, 88(9).
Contributors: n, T. Gougousi n, E. Young n & G. Parsons n
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Metal oxide thin films deposited from metal organic precursors in supercritical CO2 solutions
CHEMISTRY OF MATERIALS, 17(20), 5093–5100.
Contributors: T. Gougousi n, n, E. Young n & G. Parsons n
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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