Works (1)
Updated: July 5th, 2023 15:56
2005 journal article
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 461–466.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Administration, Oral; Animals; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A / drug effects; Cytochrome P-450 CYP3A Inhibitors; Dogs / metabolism; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / pharmacology; Female; Gastric Acid / metabolism; Injections, Intravenous / veterinary; Ketoconazole / administration & dosage; Ketoconazole / pharmacology; Male; Methadone / administration & dosage; Methadone / blood; Methadone / pharmacokinetics; Omeprazole / administration & dosage; Omeprazole / pharmacology; Proton Pump Inhibitors
TL;DR:
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
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Added: August 6, 2018
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