Works (22)
Updated: July 5th, 2023 15:56
2019 journal article
A biradical-tagged phospholipid as a polarizing agent for solid-state MAS Dynamic Nuclear Polarization NMR of membrane proteins
Solid State Nuclear Magnetic Resonance, 100, 92–101.
Contributors: D. Good*, n, D. Bolton*, M. Ward*, I. Sergeyev *, M. Caporini*, P. Scheffer *, A. Lo*
author keywords: Nuclear magnetic resonance; Dynamic nuclear polarization; Electron spin resonance; Biradical; Signal enhancement; Membrane protein; Lipid; Bilayer
MeSH headings : Glycerol / chemistry; Lipid Bilayers / chemistry; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Phospholipids / chemistry; Water / chemistry
TL;DR:
Conformational changes and an inhomogeneous distribution of the lipid-based biradicals in lipid bilayers emerged as important factors to consider for further development of this matrix-free approach for DNP of membrane proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: May 28, 2019
2019 journal article
Dielectric and Electrostatic Properties of the Silica Nanoparticle-Water Interface by EPR of pH-Sensitive Spin Probes
JOURNAL OF PHYSICAL CHEMISTRY C, 123(49), 29972–29985.
Contributors: V. Perelygin n, n, A. Marek n, E. Ou n, J. Krim n , D. Brenner n, T. Smirnova n , A. Smirnov n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 6, 2020
2019 journal article
Enhancing sensitivity of Double Electron-Electron Resonance (DEER) by using Relaxation-Optimized Acquisition Length Distribution (RELOAD) scheme
Journal of Magnetic Resonance, 298, 115–126.
Contributors: S. Milikisiyants n, n, A. Marek n, M. Jafarabadi n, J. Liu *, R. Han*, S. Wang *, A. Smirnov*
author keywords: PELDOR; DEER; EPR; Spin-labeling; Dipolar spectroscopy; Distance measurements
MeSH headings : Algorithms; Electron Spin Resonance Spectroscopy / methods; Gramicidin / chemistry; Leptospira; Models, Chemical; Models, Molecular; Rhodopsin / chemistry; Sensitivity and Specificity; Signal-To-Noise Ratio; Spin Labels
TL;DR:
A novel albeit simple approach to improve DEER sensitivity and decrease data acquisition time by introducing the signal acquisition scheme based on RELaxation Optimized Acquisition (Length) Distribution (DEER-RELOAD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 18, 2019
2019 journal article
Liquid Metal Nanoparticles as Initiators for Radical Polymerization of Vinyl Monomers
ACS MACRO LETTERS, 8(11), 1522–1527.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 9, 2019
2017 journal article
Effect of Solution Ionic Strength on the pKa of the Nitroxide pH EPR Probe 2,2,3,4,5,5-Hexamethylimidazolidin-1-oxyl
Cell Biochemistry and Biophysics, 75(2), 185–193.
Contributors: K. Margita n, n & A. Smirnov n
author keywords: pH indicator; Ionic strength; Electrolyte; Potentiometric titration; EPR; pH-sensitive nitroxides
MeSH headings : Cyclic N-Oxides / chemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Imidazolidines / chemistry; Molecular Probes / chemistry; Nitrogen Oxides / chemistry; Osmolar Concentration; Protons; Solutions; Spin Labels; Static Electricity; Water / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Glycol Chitosan Engineered Autoregenerative Antioxidant Significantly Attenuates Pathological Damages in Models of Age-Related Macular Degeneration
ACS Nano, 11(5), 4669–4685.
Contributors: R. Mitra, R. Gao *, M. Zheng, M. Wu, n, A. Smirnov n , T. Smirnova n , K. Wang, S. Chavala*, Z. Han
author keywords: age-related macular degeneration; cerium oxide nanoparticles; antioxidant; reactive oxygen species; laser-induced choroidal neovascularization
MeSH headings : Animals; Antioxidants / pharmacology; Cerium / chemistry; Cerium / pharmacology; Choroidal Neovascularization / drug therapy; Choroidal Neovascularization / prevention & control; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Macular Degeneration / physiopathology; Macular Degeneration / therapy; Male; Mice; Mice, Inbred C57BL; Oxidative Stress / drug effects; Reactive Oxygen Species / metabolism; Reactive Oxygen Species / pharmacology; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
An engineered water-soluble, biocompatible, trackable nanoceria with enriched antioxidant activity to scavenge intracellular reactive oxygen species (ROS) is reported, which may offer a superior therapeutic effect to deal with oxidative stress induced pathogeneses, such as AMD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
IKMTSL-PTE, a Phospholipid-Based EPR Probe for Surface Electrostatic Potential of Biological Interfaces at Neutral pH: Effects of Temperature and Effective Dielectric Constant of the Solvent
The Journal of Physical Chemistry B, 121(11), 2443–2453.
Contributors: n, C. Scheid n, I. Kirilyuk *, D. Trofimov* & A. Smirnov n
MeSH headings : 2-Propanol / chemistry; Electron Spin Resonance Spectroscopy; Glycerophospholipids / chemical synthesis; Glycerophospholipids / chemistry; Hydrogen-Ion Concentration; Imidazoles / chemical synthesis; Imidazoles / chemistry; Lipid Bilayers / chemistry; Micelles; Octoxynol / chemistry; Phosphatidylglycerols / chemistry; Solvents / chemistry; Spin Labels / chemical synthesis; Static Electricity; Temperature; Water / chemistry
TL;DR:
The ionization transitions of IKMTSL-PTE with pKa values close to the neutral pH range make this lipidlike molecule a valuable spectroscopic EPR probe for studying the electrostatic phenomena at biological interfaces, including lipid bilayer/membrane protein systems, that could be unstable in the acidic pH range accessible by the previously available probes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Spin Probe Multi-Frequency EPR Study of Unprocessed Cotton Fibers
Cell Biochemistry and Biophysics, 75(2), 211–226.
Contributors: A. Marek n, n & A. Smirnov n
author keywords: Spin probes; Cotton fibers; Electron paramagnetic resonance spectroscopy; Multi-frequency EPR; High-field EPR; Multi-component spectral simulations
MeSH headings : Cellulose / chemistry; Cotton Fiber; Cyclic N-Oxides / chemistry; Electron Spin Resonance Spectroscopy; Least-Squares Analysis; Solvents / chemistry; Spin Labels; Temperature; Viscosity
TL;DR:
One of the results of this study is a demonstration of a co-existence of cellulose nanodomains with different physicochemical properties such as polarity and microviscosity that are affected by solvents and temperature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
The Hydroxyl Radical is a Critical Intermediate in the Voltammetric Detection of Hydrogen Peroxide
Journal of the American Chemical Society, 138(8), 2516–2519.
Contributors: J. Roberts n, n, A. Schmidt n, T. Smirnova n & L. Sombers n
MeSH headings : Electrochemical Techniques / methods; Electron Spin Resonance Spectroscopy / methods; Hydrogen Peroxide / analysis; Hydrogen Peroxide / chemistry; Hydroxyl Radical / analysis; Hydroxyl Radical / chemistry; Pyrroles / chemistry; Spin Labels
TL;DR:
Voltammetry was combined with electron paramagnetic resonance spectroscopy to identify and define the role of an oxygen-centered radical liberated during the oxidation of H2O2, and it was demonstrated that the hydroxyl radical is a principal contributor to the voltammetry of H1O2 as signal is attenuated when this species is trapped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2013 journal article
Surface Electrostatics of Lipid Bilayers by EPR of a pH-Sensitive Spin-Labeled Lipid
Biophysical Journal, 104(1), 106–116.
Contributors: n, I. Rivera-Rivera n & A. Smirnov n
MeSH headings : Dimyristoylphosphatidylcholine / chemistry; Electrolytes / chemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Lipid Bilayers / chemistry; Lipids / chemistry; Molecular Probes / chemistry; Nitrogen Oxides / chemistry; Phosphatidylglycerols / chemistry; Spin Labels; Static Electricity; Surface Properties; Unilamellar Liposomes / chemistry
TL;DR:
A new spin-probe electron paramagnetic resonance (EPR) approach for assessing the electrostatic surface potential of lipid bilayers that is based on a recently synthesized EPR probe (IMTSL-PTE) containing a reversibly ionizable nitroxide tag attached to the lipids' polar headgroup, which shows remarkable agreement with Gouy-Chapman theory.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Unique oxidation of imidazolidine nitroxides by potassium ferricyanide: Strategy for designing paramagnetic probes with enhanced sensitivity to oxidative stress
Free Radical Research, 46(9), 1115–1122.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines
Free Radical Research, 45(4), 417–430.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity
Journal of the American Chemical Society, 133(1), 35–41.
Contributors: n, J. Pagán n, E. Morrison n, T. Smirnova n & A. Smirnov n
MeSH headings : Animals; Catalysis; Cattle; Cell Survival / drug effects; Electron Spin Resonance Spectroscopy; Ferric Compounds / chemistry; Ferric Compounds / toxicity; HeLa Cells; Humans; Hydrogen Peroxide / chemistry; Hydroxyl Radical / chemistry; Iron / chemistry; Nanoparticles / chemistry; Nanoparticles / toxicity; Oleic Acid / chemistry; Serum Albumin, Bovine / chemistry; Surface Properties
TL;DR:
The experimental protocols developed in this study could be used as one of the approaches for developing analytical assays for assessing the free radical generating activity of a variety of nanomaterials that is potentially related to their biotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Design of liposome-based pH sensitive nanoSPIN probes: Nano-sized particles with incorporated nitroxides
Analyst [London], 134(5), 904–910.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Spin-Labeled pH-Sensitive Phospholipids for Interfacial pKa Determination: Synthesis and Characterization in Aqueous and Micellar Solutions
The Journal of Physical Chemistry B, 113(11), 3453–3460.
Contributors: n, I. Kirilyuk n & A. Smirnov n
MeSH headings : Electrochemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Mercaptoethanol / chemistry; Micelles; Models, Molecular; Nitrogen / chemistry; Phospholipids / chemistry; Solutions; Spin Labels; Water
TL;DR:
The synthesis and characterization of spin-labeled phospholipids with pH-reporting nitroxides that are covalently attached to the lipid's polar headgroup are being reported, indicating that in mixed aqueous/organic solvents, the amphiphilic lipid molecules could be shielded from changing bulk conditions by a local shell of solvent molecules.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Synthesis of N'-substituted amidines through the cleavage an oxadiazolone heterocycle by weakly basic nucleophiles. Effect of the nature of the nucleophile and of the nucleophile/substrate molar ratio
Chemistry of Heterocyclic Compounds, 45(1), 59–65.
Contributors: Y. Polienko*, I. Grigor'Yev* & n
author keywords: amidine; nucleophile; nitroxyl radicals; tetrahydroimidazo[1,5-b][1,2,4]oxadiazol-2-one; 1,3-dipolar cycloaddition; EPR spectroscopy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Interfacial Surface Properties of Thiol-Protected Gold Nanoparticles: A Molecular Probe EPR Approach
Langmuir, 24(3), 609–612.
Contributors: V. Khlestkin n, J. Polienko n, n, A. Smirnov n & V. Chechik n
TL;DR:
A molecular probe technique for accessing interfacial surface electrostatics of ligand-protected gold nanoparticles using a series of ligands with variable length of the hydrocarbon bridge between the anchoring sulfur and the reporting pH-sensitive nitroxide is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Mapping Local Protein Electrostatics by EPR of pH-Sensitive Thiol-Specific Nitroxide
Biochemistry, 47(20), 5626–5637.
Contributors: n, A. Ruuge n, V. Reznikov, I. Grigor'ev & A. Smirnov n
MeSH headings : Calibration; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Nitrogen Oxides / chemistry; Proteins / chemistry; Protons; Sensitivity and Specificity; Static Electricity; Sulfhydryl Compounds / chemistry; Titrimetry
TL;DR:
It has been demonstrated that the high accuracy of pKa determination for pH-sensitive nitroxides could be achieved regardless of the frequency of measurements or the regime of spin exchange: fast at X-band and slow at W-band.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Studies toward the Synthesis of 4-(2-R-ethyl)amino-2,2,5,5-tetramethyl-3-imidazoline 1-Oxyls. Nucleophilic Substitution of Bromide in the N-Alkyl Chain of the 1,2,4-Oxadiazol-2-one Precursor
The Journal of Organic Chemistry, 73(2), 502–510.
Contributors: J. Polienko n, T. Schanding n, Y. Gatilov n, I. Grigor'ev n & n
MeSH headings : Bromides / chemistry; Electron Spin Resonance Spectroscopy / methods; Free Radicals / chemical synthesis; Free Radicals / chemistry; Hydrogen-Ion Concentration; Imidazoles / chemistry; Imidazolines / chemical synthesis; Imidazolines / chemistry; Models, Molecular; Molecular Structure; Oxazoles / chemistry; Stereoisomerism
TL;DR:
A synthetic approach to access the new nitroxides of the amidine type exhibiting pH-dependent EPR spectra through substitution of a halide in the exo-N-halogenoalkyl chain of 1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo[1,5-b]oxadiazol-2-one is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: High-field multi-frequency electron paramagnetic resonance studies
BIOPHYSICAL JOURNAL, 92(10), 3686–3695.
Contributors: T. Smirnova n , T. Chadwick n, n, O. Poluektov *, J. Van Tol *, A. Ozarowski*, G. Schaaf *, M. Ryan*, V. Bankaitis *
MeSH headings : Binding Sites; Computer Simulation; Electron Spin Resonance Spectroscopy / methods; Hydrogen Bonding; Models, Chemical; Models, Molecular; Phospholipid Transfer Proteins / chemistry; Phospholipids / chemistry; Protein Binding; Saccharomyces cerevisiae Proteins / chemistry; Solvents / chemistry; Static Electricity
TL;DR:
The data suggest the polarity gradient inside the Sec14p cavity is a significant contributor to the driving molecular forces for extracting a phospholipid from the bilayer and the enhanced g-factor resolution of EPR provides researchers with a spectroscopic tool to deconvolute two major contributions to the x-component of the nitroxide g-matrix: hydrogen-bond formation and local electrostatic effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
α-Organoelement Nitrones: Synthesis, Properties, and IR and 13C NMR Spectral and X-ray Structural Characterization
Organometallics, 26(7), 1607–1615.
Contributors: *, T. Shevelev*, T. Rybalova *, Y. Gatilov*, N. Pervukhina, A. Burdukov*, I. Grigor'ev*
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Synthesis, Structure, and X-Band (9.5 GHz) EPR Characterization of the New Series of pH-Sensitive Spin Probes: N,N-Disubstituted 4-Amino-2,2,5,5-tetramethyl-3-imidazoline 1-Oxyls
The Journal of Organic Chemistry, 70(24), 9702–9711.
Contributors: *, J. Polienko*, T. Schanding*, A. Bobko *, V. Khramtsov *, Y. Gatilov*, T. Rybalova *, A. Smirnov* , I. Grigor'ev*
MeSH headings : Electron Spin Resonance Spectroscopy / methods; Hydrogen-Ion Concentration; Imidazolines / chemical synthesis; Imidazolines / chemistry; Molecular Structure; X-Ray Diffraction
TL;DR:
An alternative approach for pKa determination is demonstrated that is based on measuring the peak-to-peak line width of the EPR spectrum in the presence of the paramagnetic broadening agent potassium ferricyanide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
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