@misc{king_smith_comins_2010, title={Regiospecific synthesis of nicotine derivatives}, volume={7,671,209}, number={2010 Mar. 2}, author={King, L. S. and Smith, E. and Comins, D. L.}, year={2010} } @misc{comins_smith_2009, title={Synthesis of nicotine derivatives from nicotine}, volume={7,553,968}, number={2009 Jun 30}, author={Comins, D. L. and Smith, E. D.}, year={2009} } @article{comins_smith_2006, title={A six-step synthesis of (S)-5-ethenyl-3-(1-methy1-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine}, volume={47}, ISSN={["0040-4039"]}, DOI={10.1016/j.tetlet.2005.12.085}, abstractNote={The anti-Parkinson’s agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate.}, number={9}, journal={TETRAHEDRON LETTERS}, author={Comins, DL and Smith, ED}, year={2006}, month={Feb}, pages={1449–1451} } @misc{comins_fevrier_smith_2006, title={Regioselective halogenation of nicotine and substituted nicotines}, volume={7,067,672}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Comins, D. L. and Fevrier, F. and Smith, E. D.}, year={2006} } @misc{king_smith_comins_2006, title={Regiospecific synthesis of nicotine derivatives}, volume={7,112,678}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={King, L. S. and Smith, E. and Comins, D. L.}, year={2006} } @misc{comins_smith_2006, title={Synthesis of nicotine derivatives from nicotine}, volume={7,132,545}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Comins, D. L. and Smith, E. D.}, year={2006} } @article{smith_fevrier_comins_2006, title={Synthesis of nicotine derivatives via reductive disilylation of (S)-nicotine}, volume={8}, ISSN={["1523-7052"]}, DOI={10.1021/ol052099q}, abstractNote={[reaction: see text] A variety of novel nicotine derivatives were prepared via reductive disilylation of (S)-nicotine. Treatment of nicotine with lithium powder and chlorotrimethylsilane afforded 1,4-bis(trimethylsilyl)-1,4-dihydronicotine in high yield. Addition of various carbonyl electrophiles and a catalytic amount of TBAF provided either C-5 substituted nicotines or 1,4-dihydronicotine derivatives.}, number={2}, journal={ORGANIC LETTERS}, author={Smith, ED and Fevrier, FC and Comins, DL}, year={2006}, month={Jan}, pages={179–182} }