@article{lascelles_freire_roe_depuy_smith_marcellin-little_2010, title={Evaluation of Functional Outcome After BFX (R) Total Hip Replacement Using a Pressure Sensitive Walkway}, volume={39}, ISSN={["0161-3499"]}, url={https://dx.doi.org/10.1111/j.1532-950X.2009.00607.x}, DOI={10.1111/j.1532-950X.2009.00607.x}, abstractNote={OBJECTIVE To evaluate stance phase limb use after cementless (BFX) total hip replacement (THR) in dogs and to relate postoperative radiographic variables to static bodyweight distribution after surgery. STUDY DESIGN Prospective clinical study. ANIMALS Dogs (n=35) that had THR. METHODS THR was performed using the BFX THR technique. Postoperative pain management regimens were similar for all dogs. Standing bodyweight distribution (%BW(distrib)) was measured using a pressure sensitive walkway and radiographs made before surgery and at 3, 6, and 12 months after surgery. Repeated measures models (with backwards-stepping to obtain the final model) were used for statistical analysis. RESULTS Temporally, %BW(distrib) to the operated limb increased (P<.0001; normal by 3 months) and decreased to the unoperated limb (P=.0001) and also increased to the pelvic limbs and decreased to the thoracic limbs. %BW(distrib) to the unoperated limb was significantly less than the operated limb at 3, 6, and 12 months after surgery. Postoperative canal fill and femur flare were significantly negatively correlated with change in %BW(distrib) (estimate=-0.24, P=.0413). CONCLUSION BFX THR results in normal %BW(distrib) to the operated limb by 3 months after surgery. A greater fill of the proximal femur may be associated with a suboptimal outcome. CLINICAL RELEVANCE BFX THR normalizes standing bodyweight distribution dogs with hip osteoarthritis. Objective evaluation of THR outcome and radiographic features may reveal factors that could be improved through changes in prosthesis design or surgical technique.}, number={1}, journal={VETERINARY SURGERY}, publisher={Blackwell Publishing Inc Malden, USA}, author={Lascelles, B. Duncan X. and Freire, Mila and Roe, Simon C. and DePuy, Venita and Smith, Eric and Marcellin-Little, Denis J.}, year={2010}, month={Jan}, pages={71–77} } @article{lascelles_hansen_thomson_pierce_boland_smith_2008, title={Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity in cats(1)}, volume={35}, ISSN={["1467-2987"]}, url={https://dx.doi.org/10.1111/j.1467-2995.2007.00367.x}, DOI={10.1111/j.1467-2995.2007.00367.x}, abstractNote={OBJECTIVE To assess the correlation between data generated by an accelerometer-based activity monitor and the distance moved in cats. STUDY DESIGN Prospective experimental study. ANIMALS Three, four-year-old, male, purpose-bred research cats, weighing between 5.1 and 5.9 kg. METHODS Part I: Collar and harness mounted accelerometers were evaluated in three cats, comparing simultaneously collected accelerometer data with movement data from computer-analyzed video. Part II: Cats wore collar and harness mounted accelerometers, and data were recorded for 4 weeks to evaluate day-to-day and week-to-week variation in activity. RESULTS Part I: 432 hours of simultaneous video and accelerometer data were collected. The correlation between accelerometer counts and distance moved was 0.82 overall. Agreement between collar and harness mounted accelerometers was excellent with only 6% of the differences in measurements lying outside the mean difference +/- 2 standard deviations. The adjusted R(2) for harness accelerometer output and 6% mobility was 0.75; for movement 0.84; and for mean velocity 0.83. Evaluation of video indicated eating, grooming and scratching created high accelerometer counts with little effect on movement. Part II: There was a significant effect of day on harness (p < 0.001) and collar (p < 0.002) counts, with counts being lowest at the weekend. There was a significant effect of week on harness-mounted accelerometer counts (p < 0.034), but not on collar-mounted accelerometer counts. Harness accelerometer counts were lowest in week 1. CONCLUSION Output from an acceleration-based digitally integrated accelerometer correlated well with distance moved and mobility in freely moving cats provided the mobility threshold in the analysis software was > or = 6%. CLINICAL RELEVANCE Acceleration-based activity monitors may allow for objective measurement of improved mobility following analgesic treatment for conditions such as osteoarthritis.}, number={2}, journal={VETERINARY ANAESTHESIA AND ANALGESIA}, author={Lascelles, B. Duncan X. and Hansen, Bernard D. and Thomson, Andrea and Pierce, Courtney C. and Boland, Elizabeth and Smith, Eric S.}, year={2008}, month={Mar}, pages={173–183} } @article{lascelles_hansen_roe_depuy_thomson_pierce_smith_rowinski_2007, title={Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis}, volume={21}, ISSN={["1939-1676"]}, DOI={10.1892/0891-6640(2007)21[410:EOCOMA]2.0.CO;2}, abstractNote={BACKGROUND There are no validated systems for measuring pain from osteoarthritis in cats. HYPOTHESIS Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments. ANIMALS Thirteen cats older than 10 years old, with owner-assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks. METHODS A collar-mounted AM measured activity and a client-specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2-5) or a placebo was administered in a blinded, randomized, cross-over manner to test the assessment systems. RESULTS The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n=9) were administered meloxicam were significantly higher than at baseline (P = .02) but not after placebo (P = .06). Baseline activity counts were not significantly different from placebo (P = .6). The CSOM data (n=13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P = .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042). CONCLUSIONS AND CLINICAL IMPORTANCE Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.}, number={3}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Lascelles, B. Duncan X. and Hansen, Bernie D. and Roe, Simon and Depuy, Venita and Thomson, Andrea and Pierce, Courtney C. and Smith, Eric S. and Rowinski, Elizabeth}, year={2007}, pages={410–416} } @article{lascelles_roe_smith_reynolds_markham_marcellin-little_bergh_budsberg_2006, title={Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs}, volume={67}, ISSN={["0002-9645"]}, url={https://dx.doi.org/10.2460/ajvr.67.2.277}, DOI={10.2460/ajvr.67.2.277}, abstractNote={Abstract Objective—To compare ground reaction forces (GRFs) measured by use of a pressure-sensitive walk-way (PSW) and a force plate (FP) and evaluate weekly variation in the GRFs and static vertical forces in dogs. Animals—34 clinically normal dogs and 5 research dogs with lameness. Procedure—GRF data were collected from 5 lame and 14 clinically normal dogs by use of an FP and a PSW. Peak vertical force (PVF), vertical impulse (VI), and velocity measurements (determined by use of photocells and PSW data) were compared between groups. Peak vertical force, VI, stride length, ground phase time (ie, contact time), and static body weight distribution data were collected on 2 occasions, 1 week apart, in 20 different clinically normal dogs by use of a PSW; week-to-week variation in values was evaluated. Results—Measurements of velocity derived by use of the photocells were not different from those derived by use of the PSW. For any 1 limb, values derived by use of the PSW were significantly lower than values derived with the FP. For values obtained by use of either technique, there were no differences between left and right limbs except for values of PVF measured via PSW in forelimbs. Values of PVF, VI, contact time, stride length, and static weight distribution generated by the PSW did not vary from week to week. Conclusions and Clinical Relevance—Values for GRFs varied between the FP and PSW. However, data derived by use of PSW were consistent and could be used to evaluate kinetic variables over time in the same dog.}, number={2}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Lascelles, BDX and Roe, SC and Smith, E and Reynolds, L and Markham, J and Marcellin-Little, D and Bergh, MS and Budsberg, SC}, year={2006}, month={Feb}, pages={277–282} }