@article{moore_mariani_van wettere_borst_2013, title={Chronic Compressive Myelopathy and Progressive Neurologic Signs Associated with Melarsomine Dihydrochloride Administration in a Dog}, volume={49}, ISSN={["1547-3317"]}, url={http://dx.doi.org/10.5326/jaaha-ms-5911}, DOI={10.5326/jaaha-ms-5911}, abstractNote={A 7 yr old castrated male Great Dane presented with a history of progressive myelopathy following the intramuscular injection of melarsomine dihydrochloride 8 wk previously. MRI revealed paraspinal and epidural abscesses at the 13th thoracic (T13) and first lumbar (L1) disc space. The dog’s condition worsened despite medical management, necessitating surgical decompression. Surgical decompression resulted in rapid improvement of the patient’s clinical signs. Histopathologic evaluation of the lesions revealed pyogranulomatous inflammation. Cultures of fluid and tissue within the lesions were negative for bacterial growth, and no infectious organisms were visualized histologically. Melarsomine-associated neurologic signs can be chronic and progressive in nature, presumably secondary to ongoing sterile inflammation that may result in spinal cord compression.}, number={6}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Moore, Sarah A. and Mariani, Christopher L. and Van Wettere, Arnaud and Borst, Luke B.}, year={2013}, pages={389–393} }
 @article{wettere_kullmam_hinton_law_2013, title={Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (oryzias latipes) following hepatic injury}, volume={149}, DOI={10.1016/j.jcpa.2013.03.008}, abstractNote={Laboratory fish species are used increasingly in biomedical research and are considered robust models for the study of regenerative processes. Studies investigating the response of the fish liver to injury have demonstrated the presence of a ductular reaction and oval-like cells in injured and regenerating liver. To date, however, it is unclear if this cell population is the piscine equivalent of oval cells (OCs) or intermediate hepatobiliary cells (IHBCs) identified in rodents and man, respectively. The present study defines the process of OC differentiation in fish liver using histopathology, immunohistochemistry and transmission electron microscopy. To generate OC proliferation in Japanese medaka (Oryzias latipes), hepatic injury was induced by exposure of adult fish to either microcystin LR or dimethylnitrosamine. A transgenic strain of medaka expressing a red fluorescent protein (RFP) exclusively in hepatocytes was used. The morphological response to injury was characterized by a ductular reaction comprised of cytokeratin (CK) AE1/AE3+ OCs progressing to IHBCs variably positive for CK and RFP and finally mature RFP+ hepatocytes and CK+ cholangiocytes. These observations support a bipotential differentiation pathway of fish OCs towards hepatocytes and cholangiocytes. Ultrastructural morphology confirmed the presence of OCs and differentiation towards hepatocytes. These results demonstrated clear similarities between patterns of reaction to injury in fish and mammalian livers. They also confirm the presence of, and support the putative bipotential lineage capabilities of, the fish OC.}, number={4}, journal={Journal of Comparative Pathology}, author={Wettere, A. J. Van and Kullmam, Seth and Hinton, D. E. and Law, J. M.}, year={2013}, pages={434–445} }
 @article{van wettere_ley_scott_buckanoff_degernes_2013, title={Mycoplasma Corogypsi-Associated Polyarthritis and Tenosynovitis in Black Vultures (Coragyps atratus)}, volume={50}, ISSN={["1544-2217"]}, DOI={10.1177/0300985812457791}, abstractNote={ Three wild American black vultures ( Coragyps atratus) were presented to rehabilitation centers with swelling of multiple joints, including elbows, stifles, hocks, and carpal joints, and of the gastrocnemius tendons. Cytological examination of the joint fluid exudate indicated heterophilic arthritis. Radiographic examination in 2 vultures demonstrated periarticular soft tissue swelling in both birds and irregular articular surfaces with subchondral bone erosion in both elbows in 1 bird. Prolonged antibiotic therapy administered in 2 birds did not improve the clinical signs. Necropsy and histological examination demonstrated a chronic lymphoplasmacytic arthritis involving multiple joints and gastrocnemius tenosynovitis. Articular lesions varied in severity and ranged from moderate synovitis and cartilage erosion and fibrillation to severe synovitis, diffuse cartilage ulceration, subchondral bone loss and/or sclerosis, pannus, synovial cysts, and epiphyseal osteomyelitis. No walled bacteria were observed or isolated from the joints. However, mycoplasmas polymerase chain reactions were positive in at least 1 affected joint from each bird. Mycoplasmas were isolated from joints of 1 vulture that did not receive antibiotic therapy. Sequencing of 16S rRNA gene amplicons from joint samples and the mycoplasma isolate identified Mycoplasma corogypsi in 2 vultures and was suggestive in the third vulture. Mycoplasma corogypsi identification was confirmed by sequencing the 16S-23S intergenic spacer region of mycoplasma isolates. This report provides further evidence that M. corogypsi is a likely cause of arthritis and tenosynovitis in American black vultures. Cases of arthritis and tenosynovitis in New World vultures should be investigated for presence of Mycoplasma spp, especially M. corogypsi. }, number={2}, journal={VETERINARY PATHOLOGY}, author={Van Wettere, A. J. and Ley, D. H. and Scott, D. E. and Buckanoff, H. D. and Degernes, L. A.}, year={2013}, month={Mar}, pages={291–298} }
 @article{van wettere_law_hinton_kullman_2013, title={Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes}, volume={42}, ISSN={0192-6233 1533-1601}, url={http://dx.doi.org/10.1177/0192623313499643}, DOI={10.1177/0192623313499643}, abstractNote={ Transgenic organisms that express fluorescent proteins are used frequently for in vivo visualization of proteins and cells. The phenotype of a transgenic medaka ( Oryzias latipes) strain that expresses a red fluorescent protein (RFP) in hepatocytes was characterized using light and fluorescence microscopy, immunohistochemistry, and transmission electron microscopy (TEM). Expression of RFP was first detected by confocal fluorescence microscopy in the location of the liver bud of live medaka embryos at 60 hr postfertilization (developmental stage 27). Subsequently, RFP signal was observed exclusively in hepatocytes throughout life using fluorescence microscopy in live fish and immunohistochemistry in formalin-fixed, paraffin-embedded liver sections. As the fish aged, prominent intracytoplasmic eosinophilic inclusions immunoreactive for RFP were observed by light microscopy and were correlated with membrane-bound electron dense inclusions on TEM. These results define the onset and location of RFP expression in the Tg(zf.L-fabp:DsRed) medaka and characterize a histologic phenotype that results from RFP expression in hepatocytes. }, number={3}, journal={Toxicologic Pathology}, publisher={SAGE Publications}, author={Van Wettere, Arnaud J. and Law, J. Mac and Hinton, David E. and Kullman, Seth W.}, year={2013}, month={Aug}, pages={616–621} }
 @article{lewbart_christian_harms_van wettere_2010, title={A Comparison of Heavy Metal Concentrations and Health Assessment in Asian Clams Corbicula fluminea from Florida and North Carolina}, volume={22}, ISSN={["1548-8667"]}, DOI={10.1577/h09-041.1}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF AQUATIC ANIMAL HEALTH}, author={Lewbart, Gregory A. and Christian, Larry S. and Harms, Craig A. and Van Wettere, Arnaud J.}, year={2010}, month={Jun}, pages={73–77} }
 @article{van wettere_degernes_barnes_2010, title={Combined hepatocellular-cholangiocarcinoma in a lesser flamingo (Phoenicopterus minor)}, volume={39}, ISSN={["1465-3338"]}, DOI={10.1080/03079457.2010.493553}, abstractNote={A case of combined hepatocellular-cholangiocarcinoma (CHCC) in an adult male lesser flamingo (Phoenicopterus minor) that was part of a breeding programme at a private facility is reported. Grossly, the liver was markedly enlarged with multifocal, well-circumscribed, pinpoint to 2 cm diameter pale tan nodular masses. Histologically, the hepatic parenchyma was replaced by neoplastic cells that demonstrated hepatocellular and, less frequently, biliary epithelial cell differentiation. Positive pan-cytokeratin (AE1/AE3/PCK26) immunolabelling of the neoplastic cells forming bile ducts with the scattered immunoreactivity of cells forming glandular structures within the areas of hepatocellular differentiation supported the diagnosis. No metastases were detected. CHCC is a rare neoplasm in mammals and birds. This is the first report where gross, histological, and immunohistochemical characteristics of CHCC in a bird are described, and the first report of CHCC in a lesser flamingo.}, number={4}, journal={AVIAN PATHOLOGY}, author={Van Wettere, A. J. and Degernes, L. A. and Barnes, H. John}, year={2010}, pages={275–278} }
 @article{bizikova_linder_suter_van wettere_olivry_2009, title={Canine cutaneous epitheliotropic T-cell lymphoma with vesiculobullous lesions resembling human bullous mycosis fungoides}, volume={20}, ISSN={0959-4493 1365-3164}, url={http://dx.doi.org/10.1111/j.1365-3164.2009.00760.x}, DOI={10.1111/j.1365-3164.2009.00760.x}, abstractNote={Abstract}, number={4}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Bizikova, Petra and Linder, Keith E. and Suter, Steven E. and Van Wettere, Arnaud J. and Olivry, Thierry}, year={2009}, month={Aug}, pages={281–288} }
 @article{van wettere_redig_wallace_bourgeault_bechtold_2009, title={Mechanical evaluation of external skeletal fixator-intramedullary pin tie-in configurations applied to cadaveral humeri from red-tailed hawks (Buteo jamaicensis)}, volume={23}, number={4}, journal={Journal of Avian Medicine and Surgery}, author={Van Wettere, A. J. and Redig, P. T. and Wallace, L. J. and Bourgeault, C. A. and Bechtold, J. E.}, year={2009}, pages={277–285} }
 @article{van wettere_wallace_redig_bourgeault_bechtold_2009, title={Mechanical evaluation of various external skeletal fixator-intramedullary pin tie-in configurations using a tubular plastic bone model}, volume={23}, number={4}, journal={Journal of Avian Medicine and Surgery}, author={Van Wettere, A. J. and Wallace, L. J. and Redig, P. T. and Bourgeault, C. A. and Bechtold, J. E.}, year={2009}, pages={263–276} }
 @misc{remick_van wettere_williams_2009, title={Neoplasia in prosimians: Case series from a captive prosimian population and literature review}, volume={46}, number={4}, journal={Veterinary Pathology}, author={Remick, A. K. and Van Wettere, A. J. and Williams, C. V.}, year={2009}, pages={746–772} }
 @article{van wettere_linder_suter_olby_2009, title={Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features}, volume={46}, ISSN={0300-9858 1544-2217}, url={http://dx.doi.org/10.1354/vp.08-VP-0012-V-BC}, DOI={10.1354/vp.08-VP-0012-V-BC}, abstractNote={ A primary intracerebral plasmacytoma was identified in a 7-year-old spayed female Boston Terrier. Grossly, a well-demarcated, 2 cm in diameter, roughly spherical tumor was in the rostral aspect of the left cerebral hemisphere. Histologically, the neoplasm was composed of sheets of round cells with distinct plasmacytoid features and marked anisocytosis and anisokaryosis. Cells were positive for vimentin, CD18, CD79a, and lambda light-chain, and negative for kappa light chain, cytokeratin, lysozyme, glial fibrillary acidic protein, and S100 protein. Clonally rearranged B-cell antigen receptor genes were detected by PARR (polymerase chain reaction for antigen receptor rearrangements), confirming clonal proliferation of B lymphocytes. Although primary solitary intracerebral plasmacytoma is rare in dogs and other species, it should be included in the differential diagnosis for central nervous system round-cell neoplasms. Clonality testing can be utilized to support the histological diagnosis of this neoplasm type. }, number={5}, journal={Veterinary Pathology}, publisher={SAGE Publications}, author={Van Wettere, A. J. and Linder, K. E. and Suter, S. E. and Olby, N. J.}, year={2009}, month={May}, pages={949–951} }
 @article{sheats_wetter_snyder_jones_2008, title={Disseminated large granular lymphoma in a horse}, volume={20}, ISSN={["2042-3292"]}, DOI={10.2746/095777308X343860}, abstractNote={Summary}, number={9}, journal={EQUINE VETERINARY EDUCATION}, author={Sheats, M. K. and Wetter, A. J. N. J. and Snyder, L. A. and Jones, S. L.}, year={2008}, month={Sep}, pages={459–463} }
 @article{chinnadurai_brown_van wettere_tuttle_fatzinger_linder_harms_2008, title={MORTALITIES ASSOCIATED WITH SEPSIS, PARASITISM, AND DISSEMINATED ROUND CELL NEOPLASIA IN YELLOW-LIPPED SEA KRAITS (LATICAUDA COLUBRINA)}, volume={39}, ISSN={["1937-2825"]}, DOI={10.1638/2008-0018.1}, abstractNote={Abstract This case series describes multiple mortalities associated with sepsis, neoplasia, and endoparasitism in yellow-lipped sea kraits (Laticauda colubrina) at an exhibit aquarium. Over a 2-yr period, the facility kept 42 L. colubrina, of which 38 died and 19 were suitable for necropsy and histopathology. The common clinical syndrome seen in these animals consisted of partial to compete anorexia, increased time spent “hauled-out” on land, intermittent regurgitation, chronic lethargy, and weight loss. Few animals died without premonitory signs. Nutritional support and treatment for presumptive parasitism and sepsis were unsuccessful. The mortality seen in this collection of sea kraits could be placed into three groups; one group of animals (n = 9) died of sepsis secondary to necrotizing enteritis or pneumonia; one group (n = 6) remained apparently healthy for over 1 yr and then died with multifocal granulomas and sepsis; and the last group (n = 3) died as a result of multicentric lymphoid neoplasia with secondary sepsis. The unifying factor in the majority of these cases is the presence of septicemia as the proximate cause of death. Based on the clinical picture, it is presumed that an immunosuppressive event, such as transport, captivity stress, or possible concurrent viral infection, resulted in a septic event and death.}, number={4}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Chinnadurai, Sathya K. and Brown, Danielle L. and Van Wettere, Arnaud and Tuttle, Allison D. and Fatzinger, Michael H. and Linder, Keith E. and Harms, Craig A.}, year={2008}, month={Dec}, pages={626–630} }
 @article{chinnadurai_van wettere_linder_harms_devoe_2008, title={Secondary amyloidosis and renal failure in a captive California sea lion (Zalophus californianus)}, volume={39}, ISSN={["1937-2825"]}, DOI={10.1638/2007-0096R.1}, abstractNote={Abstract A 16-yr-old, captive-born, female California sea lion (Zalophus californianus) was evaluated for intermittent lethargy, partial anorexia, and polydipsia of 2 wk duration. The animal was immobilized for physical examination. It was in thin body condition, with multifocal mucosal ulcerations over the caudal and ventral tongue. Blood was collected for hematology, serum chemistry, and leptospirosis serology. Serum chemistry revealed severe azotemia, mild hyperglycemia, and severe hyperphosphatemia. The animal went into cardiac arrest during recovery from anesthesia and died. On histopathology, abundant amorphous, finely fibrillar, eosinophilic material was deposited in the kidneys, and smaller amounts of the same material were found in the splenic and pancreatic vessels; these findings are consistent with systemic secondary amyloidosis. The animal also had chronic nephritis, which, coupled with renal amyloidosis, resulted in renal failure and death. Systemic amyloidosis should be considered as an additional differential diagnosis for renal failure in California sea lions.}, number={2}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Chinnadurai, Sathya K. and Van Wettere, Arnaud and Linder, Keith E. and Harms, Craig A. and DeVoe, Ryan S.}, year={2008}, month={Jun}, pages={274–278} }
 @article{troan_perelygina_patrusheva_van wettere_hilliard_loomis_de voe_2007, title={Naturally transmitted herpesvirus papio-2 infection in a black and white colobus monkey}, volume={231}, ISSN={["1943-569X"]}, DOI={10.2460/javma.231.12.1878}, abstractNote={Abstract}, number={12}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Troan, Brigid V. and Perelygina, Ludmila and Patrusheva, Irina and Van Wettere, Arnaud J. and Hilliard, Julia K. and Loomis, Michael R. and De Voe, Ryan S.}, year={2007}, month={Dec}, pages={1878–1883} }
 @article{van wettere_wunschmann_latimer_redig_2005, title={Adenovirus infection in taita falcons (Falco fasciinucha) and hybrid falcons (Falco rusticolus x Falco peregrinus)}, volume={19}, ISSN={["1082-6742"]}, DOI={10.1647/2004-028}, abstractNote={Abstract Three taita falcon (Falco fasciinucha) nestlings and 3 cohoused hybrid falcon (F rusticolus × F peregrinus) nestlings died after showing lethargy and anorexia for 4–5 days. Major lesions in the falcons were necrotizing hepatitis, splenitis, and lymphoplasmacytic nephritis. One hybrid falcon also had a heterophilic nephritis. Intranuclear inclusion bodies were present in the hepatocytes of the taita falcons and in the renal tubular epithelial cells of 1 hybrid falcon. Adenoviral particles were found in the cloacal content of 2 taita falcons. DNA in situ hybridization revealed aviadenoviral nucleic acid within the nuclei of hepatocytes of a taita falcon and a hybrid falcon and in the tubular epithelial cells of a hybrid falcon. Aviadenoviral DNA was amplified by polymerase chain reaction in the liver of taita falcons and hybrid falcons. The death of these birds was attributed to the aviadenovirus infection; however, the source of the virus was not determined. Predisposing factors for the outbreak of the viral infection in these falcons may have included transport stress, lack of quarantine measures, and cohousing of falcon species originating from isolated populations with other falcon species.}, number={4}, journal={JOURNAL OF AVIAN MEDICINE AND SURGERY}, author={Van Wettere, AJ and Wunschmann, A and Latimer, KS and Redig, PT}, year={2005}, month={Dec}, pages={280–285} }