2010 journal article

Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 10(10), 6305–6312.

By: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, N. Monteiro-Riviere*, R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*

Contributors: A. Doraiswamy n, A. Ovsianikov, S. Gittard*, N. Monteiro-Riviere*, R. Crombez, E. Montalvo, W. Shen, B. Chichkov, R. Narayan*

author keywords: Microneedle; Transdermal Drug Delivery; Rapid Prototyping; Nanomaterials; Human Epidermal Keratinocytes
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Cell Survival / drug effects; Cells, Cultured; Drug Delivery Systems / instrumentation; Elastic Modulus; Equipment Design; Female; Hardness; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Materials Testing; Microscopy, Confocal; Microscopy, Electron, Scanning; Microtechnology / methods; Nanostructures / administration & dosage; Needles; Polymerization; Quantum Dots; Skin / drug effects; Skin / metabolism; Swine
TL;DR: Microneedies were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration and suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Laser micromachining for biomedical applications

JOM, 61(9), 35–40.

By: P. Miller n, R. Aggarwal n, A. Doraiswamy n, Y. Lin*, Y. Lee n & R. Narayan n

TL;DR: In vitro studies showed that microscale grooves on silicon substrates may be used to orient human aortic vascular smooth muscle cells, and it is anticipated that the use of laser micromachining for modifying medical and dental devices will become more significant over the coming years. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Rapid prototyping of ossicular replacement prostheses

Applied Surface Science, 253(15), 6603–6607.

By: A. Ovsianikov*, B. Chichkov*, O. Adunka*, H. Pillsbury*, A. Doraiswamy n & R. Narayan n

author keywords: two-photon polymerization; rapid prototyping; ossicular replacement prosthesis
TL;DR: The results demonstrate that two-photon polymerization is able to create ossicular replacement prostheses and other medical devices with a larger range of sizes, shapes and materials than other microfabrication techniques. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2006 journal article

Two photon induced polymerization of organic-inorganic hybrid biomaterials for microstructured medical devices

ACTA BIOMATERIALIA, 2(3), 267–275.

By: A. Doraiswamy*, C. Jin*, R. Narayan n, P. Mageswaran n, P. Mente n, R. Modi*, R. Auyeung*, D. Chrisey*, A. Ovsianikov*, B. Chichkov*

author keywords: two photon induced polymerization; Ormocer (R); tissue engineering; microneedles
MeSH headings : Animals; Drug Carriers; Equipment Design / methods; Equipment and Supplies; Inorganic Chemicals / chemistry; Materials Testing / methods; Microchemistry / methods; Microscopy, Electron, Scanning; Neurons / cytology; Neurons / ultrastructure; Organic Chemicals / chemistry; Photons; X-Ray Diffraction
TL;DR: Three-dimensional microstructured medical devices, including microneedles and tissue engineering scaffolds, were fabricated by two photon induced polymerization of Ormocer organic-inorganic hybrid materials to suggest that two photon inducing polymerization is able to create medical microdevices with a larger range of sizes, shapes, and materials than conventional microfabrication techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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