@article{gluck_rahgozar_ingle_rofail_petrosian_cline_jordan_roos_maclellan_shemin_et al._2011, title={Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering}, volume={99B}, number={1}, journal={Journal of Biomedical Materials Research. Part B, Applied Biomaterials}, author={Gluck, J. M. and Rahgozar, P. and Ingle, N. P. and Rofail, F. and Petrosian, A. and Cline, M. G. and Jordan, M. C. and Roos, K. P. and MacLellan, W. R. and Shemin, R. J. and et al.}, year={2011}, pages={180–190} }
 @article{chung_ingle_montero_kim_king_2010, title={Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning}, volume={6}, ISSN={["1878-7568"]}, DOI={10.1016/j.actbio.2009.12.007}, abstractNote={Current surgical therapy for diseased vessels less than 6mm in diameter involves bypass grafting with autologous arteries or veins. Although this surgical practice is common, it has significant limitations and complications, such as occlusion, intimal hyperplasia and compliance mismatch. As a result, cardiovascular biomaterials research has been motivated to develop tissue-engineered blood vessel substitutes. In this study, vascular tissue engineering scaffolds were fabricated using two different approaches, namely melt spinning and electrospinning. Small diameter tubes were fabricated from an elastomeric bioresorbable 50:50 poly(l-lactide-co-epsilon-caprolactone) copolymer having dimensions of 5mm in diameter and porosity of over 75%. Scaffolds electrospun from two different solvents, acetone and 1,1,1,3,3,3-hexafluoro-2-propanol were compared in terms of their morphology, mechanical properties and cell viability. Overall, the mechanical properties of the prototype tubes exceeded the transverse tensile values of natural arteries of similar caliber. In addition to spinning the polymer separately into melt-spun and electrospun constructs, the approach in this study has successfully demonstrated that these two techniques can be combined to produce double-layered tubular scaffolds containing both melt-spun macrofibers (<200microm in diameter) and electrospun submicron fibers (>400nm in diameter). Since the vascular wall has a complex multilayered architecture and unique mechanical properties, there remain several significant challenges before a successful tissue-engineered artery is achieved.}, number={6}, journal={ACTA BIOMATERIALIA}, author={Chung, Sangwon and Ingle, Nilesh P. and Montero, Gerardo A. and Kim, Soo Hyun and King, Martin W.}, year={2010}, month={Jun}, pages={1958–1967} }
 @article{ingle_king_zikry_2010, title={Finite element analysis of barbed sutures in skin and tendon tissues}, volume={43}, ISSN={0021-9290}, url={http://dx.doi.org/10.1016/j.jbiomech.2009.11.012}, DOI={10.1016/j.jbiomech.2009.11.012}, abstractNote={Barbed surgical sutures are a new type of knotless suture that are currently being used clinically in cosmetic and plastic surgery procedures for faster healing and better cosmesis. Clinical studies are also underway to evaluate their performance in other deep tissue applications. However, little is known about their intrinsic mechanical behavior and their interactions with surrounding tissues. The primary objective of the current study was to analyze the mechanical behavior of barbed sutures using a finite element analysis approach. First, the effect of applying a point-pressure load to the tip of the barb and measuring its effect on barb displacement was studied. Second, the effect of an applied displacement to a barb anchored either in skin or tendon material for both the suture and the surrounding tissue. The results indicate that the flexibility of the barb can be increased or decreased by changing the barb geometry. It was concluded that the barb geometry and design need to be modified for use with different types of tissue. For example, in order to achieve the best mechanical anchoring with skin tissue the barb should be more flexible compared to the one designed to work with tendon tissue. The uniqueness of this study is that it is the first to establish a virtual prototyping and designing method for barbed sutures. For example, a new and improved virtual design of barb geometry is proposed and validated. It also provides the first report on how to develop a virtual bench top suture/tissue pullout testing environment.}, number={5}, journal={Journal of Biomechanics}, publisher={Elsevier BV}, author={Ingle, N.P. and King, M.W. and Zikry, M.A.}, year={2010}, month={Mar}, pages={879–886} }
 @article{ingle_king_2010, title={Optimizing the tissue anchoring performance of barbed sutures in skin and tendon tissues}, volume={43}, ISSN={["1873-2380"]}, DOI={10.1016/j.jbiomech.2009.08.033}, abstractNote={The focus of the current work was to study how the geometric design of a single barbed monofilament suture effects its biomechanical behavior. Different cut angles and cut depths of barbs were prepared and tested in vitro for their tensile and tissue anchoring properties by means of a novel suture/tissue pullout test. Experiments were also performed using bovine tendon and porcine skin tissues. The experimental results revealed that since tendon tissue has a higher modulus than skin it needs a more rigid barb to penetrate and anchor the surrounding tissue. A cut angle of 150° and a cut depth of 0.18 mm are therefore recommended. On the other hand, for the softer skin tissue, a cut angle of 170° and a cut depth of 0.18 mm provides a more flexible barb that gives superior skin tissue anchoring. These findings confirm that the future development of barbed suture technology requires a detailed understanding of the biomechanical properties of the tissue in which they are to be used. This will lead to the future development of a range of tissue-specific barbed sutures.}, number={2}, journal={JOURNAL OF BIOMECHANICS}, author={Ingle, N. P. and King, M. W.}, year={2010}, month={Jan}, pages={302–309} }
 @article{schenke-layland_rofail_heydarkhan_gluck_ingle_angelis_choi_maclellan_beygui_shemin_et al._2009, title={The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies.}, volume={9}, url={http://europepmc.org/abstract/med/19524289}, DOI={10.1016/j.biomaterials.2009.05.033}, abstractNote={Synthetic polymers or naturally-derived extracellular matrix (ECM) proteins have been used to create tissue engineering scaffolds; however, the need for surface modification in order to achieve polymer biocompatibility and the lack of biomechanical strength of constructs built using proteins alone remain major limitations. To overcome these obstacles, we developed novel hybrid constructs composed of both strong biosynthetic materials and natural human ECM proteins. Taking advantage of the ability of cells to produce their own ECM, human foreskin fibroblasts were grown on silicon-based nanostructures exhibiting various surface topographies that significantly enhanced ECM protein production. After 4 weeks, cell-derived sheets were harvested and histology, immunochemistry, biochemistry and multiphoton imaging revealed the presence of collagens, tropoelastin, fibronectin and glycosaminoglycans. Following decellularization, purified sheet-derived ECM proteins were mixed with poly(epsilon-caprolactone) to create fibrous scaffolds using electrospinning. These hybrid scaffolds exhibited excellent biomechanical properties with fiber and pore sizes that allowed attachment and migration of adipose tissue-derived stem cells. Our study represents an innovative approach to generate strong, non-cytotoxic scaffolds that could have broad applications in tissue regeneration strategies.}, number={27}, journal={Biomaterials}, author={Schenke-Layland, K and Rofail, F and Heydarkhan, S and Gluck, JM and Ingle, NP and Angelis, E and Choi, CH and MacLellan, WR and Beygui, RE and Shemin, RJ and et al.}, year={2009}, month={Jun}, pages={4665–4675} }
 @article{ingle_doke_2006, title={Analysis of Sunnhemp fibers processed using jute spinning system}, volume={23}, ISSN={["0926-6690"]}, DOI={10.1016/j.indcrop.2002.09.002}, abstractNote={Sunnhemp is a coarse, strong and stiff bast fiber similar to jute fiber but not considered by textile technologists for the purpose of spinning into yarn, which can be further woven into fabric. The objective of this study was to spin 100% Sunnhemp fibers in to different yarns of same count on a jute spinning system by using different number of passages of carding and drawing to find how the structural changes in the fiber after each stage mechanical processing. To observe structural changes in the fiber, random sampling method was used to collect the fiber samples at various stages of processing and analysis of each fiber was done using microscope. It was found that a lot of changes occur in the fiber structure due to mechanical processing. The structural details about the fiber entity are depicted in the article. Further, correlation was established between various fiber parameters such as fiber length, fiber diameter and fiber number of branches. Finally, an exponential frequency distribution of the fiber lengths for various stages in the spinning process was calculated. This curve explains how the degree of individualization increases as the fiber length decreases and makes the fiber spinnable into better quality yarn.}, number={3}, journal={INDUSTRIAL CROPS AND PRODUCTS}, author={Ingle, NP and Doke, SS}, year={2006}, month={May}, pages={235–243} }
 @article{ingle_doke_2006, title={Optimisation of spinning parameters for processing of 100% sunnhemp fibers}, volume={23}, ISSN={["0926-6690"]}, DOI={10.1016/j.indcrop.2002.09.001}, abstractNote={Abstract This study was an attempt to spin 100% sunnhemp fibers, grown in Akola district of Maharashtra, India, on Jute spinning system. The sunnhemp fibers were first sprayed with oil and then softened. These fibers were then processed through various machine sequence by varying the number of carding and drawing machines. The yarn was spun in each case and tested for Count Strength Product and Evenness. This yarn was then used as a weft yarn to weave a 3/1-drill fabric with a cotton warp and tested for tensile strength. It was concluded that the set III with three carding and three drawing sequence gave an even yarn. The optimum twist per inch in the yarn was found to be 6.0.}, number={3}, journal={INDUSTRIAL CROPS AND PRODUCTS}, author={Ingle, NP and Doke, SS}, year={2006}, month={May}, pages={225–234} }