Works (2)

Updated: July 5th, 2023 15:56

2008 journal article

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

STRUCTURE, 16(11), 1702–1713.

By: D. Sullivan n, B. Bobay n, D. Kojetin*, R. Thompson n, M. Rance*, M. Strauch*, J. Cavanagh n

MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Thermodynamics; Transcription Factors / chemistry; Transcription Factors / metabolism
TL;DR: RDC-refined NMR solution structures and dynamic properties of the DNA-binding domains of three Bacillus subtilis transition-state regulators: AbrB, Abh, and SpoVT are presented and a structural model of the complex between AbrBN(55) and its cognate promoter, abrB8 is generated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation

BIOCHEMISTRY, 45(20), 6260–6266.

By: J. Sharp n, D. Sullivan n, J. Cavanagh n & K. Tomer n

MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; Circular Dichroism; Kinetics; Mass Spectrometry; Methionine / metabolism; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Conformation; Structure-Activity Relationship
TL;DR: It is found that oxidation causes a three-stage conformational change in Spo0F, a regulator of sporulation in Bacillus subtilis, and the dramatic structural changes affect only the region surrounding the active site, while the remainder of the structure remains relatively unperturbed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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