Caryn L. Heldt

Works (4)

Updated: July 5th, 2023 15:53

2011 journal article

Porcine parvovirus removal using trimer and biased hexamer peptides

Biotechnology Journal, 7(4), 558–565.

By: C. Heldt n, P. Gurgel n, L. Jaykus n & R. Carbonell n

author keywords: Affinity adsorption; Biosafety; Bioseparation; Ligand; Virus removal
MeSH headings : Adsorption; Chromatography, Affinity; Humans; Parvovirus, Porcine / chemistry; Parvovirus, Porcine / isolation & purification; Peptides / chemical synthesis; Peptides / chemistry; Plasma / chemistry; Plasma / virology
TL;DR: This study demonstrates that trimeric and hexameric peptides may have different, matrix‐specific roles to play in virus removal applications, and in general, the hexamer ligand may perform better for binding of specific viruses, whereas the trimer ligand might have more broadly reactive virus‐binding properties. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2009 journal article

Influence of Peptide Ligand Surface Density and Ethylene Oxide Spacer Arm on the Capture of Porcine Parvovirus

BIOTECHNOLOGY PROGRESS, 25(5), 1411–1418.

By: C. Heldt n, P. Gurgel n, L. Jaykus n & R. Carbonell n

author keywords: viral clearance; affinity resins; parvovirus; affinity ligands; combinatorial libraries
MeSH headings : Adsorption; Cells, Cultured; Chromatography, Affinity / methods; Ethylene Oxide / chemistry; Humans; Ligands; Particle Size; Parvovirus, Porcine / isolation & purification; Peptides / chemistry; Plasma / chemistry; Surface Properties
TL;DR: Results indicate that low peptide densities enhance binding selectivity, facilitating specific peptide‐virus binding even in the presence of plasma proteins which can theoretically bind nonspecifically. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Identification of trimeric peptides that bind porcine parvovirus from mixtures containing human blood plasma

BIOTECHNOLOGY PROGRESS, Vol. 24, pp. 554–560.

By: C. Heldt n, P. Gurgel n, L. Jaykus n & R. Carbonell n

MeSH headings : Animals; Complex Mixtures / isolation & purification; Complex Mixtures / metabolism; Humans; Oligopeptides / metabolism; Parvovirus, Porcine / isolation & purification; Parvovirus, Porcine / metabolism; Plasma / metabolism; Plasma / virology
TL;DR: The results of this work indicate that small peptide ligand resins have the potential to be used in virus removal processes where removal of contaminating virus is necessary to ensure product safety. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

A colorimetric assay for viral agents that produce cytopathic effects

Journal of Virological Methods, 135(1), 56–65.

By: C. Heldt, R. Hernandez, U. Mudiganti, P. Gurgel, D. Brown & R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

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