Nanette M Nascone-Yoder
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Works (41)
Updated: April 3rd, 2024 17:57
2024 journal article
Developmental regulation of cellular metabolism is required for intestinal elongation and rotation
DEVELOPMENT, 151(1).
author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR:
Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation.
(via Semantic Scholar)
journals.biologists.com (publisher PDF)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024
2024 journal article
Morphoelastic models discriminate between different mechanisms of left-right asymmetric stomach morphogenesis
CELLS & DEVELOPMENT, 177.
author keywords: Stomach morphogenesis; Morphoelasticity; Modeling; left/right asymmetry
TL;DR:
A continuum model of asymmetric stomach morphogenesis is developed using a morphoelastic framework and reveals that, of the various differential growth mechanisms tested, only one category is consistent with the leftward stomach curvature observed in wild-type embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024
2024 article
The people behind the papers - Julia Grzymkowski and Nanette Nascone-Yoder
Grzymkowski, J., & Nascone-Yoder, N. (2024, January). DEVELOPMENT, Vol. 151.
TL;DR:
Exposure of Xenopus embryos to atrazine, a widely-used herbicide, can disrupt cellular metabolism in the developing gut tube and lead to intestinal malrotation, a prevalent birth anomaly.
(via Semantic Scholar)
Source: Web Of Science
Added: March 11, 2024
2023 journal article
Rare variants in <i>CAPN2</i> increase risk for isolated hypoplastic left heart syndrome
HUMAN GENETICS AND GENOMICS ADVANCES, 4(4).
TL;DR:
The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2023
2022 journal article
Normal Table of Xenopus development: a new graphical resource
DEVELOPMENT, 149(14).
author keywords: Xenopus laevis; Normal table; Amphibian development; FETAX; EAMA; AMA; Metamorphosis; Embryo
MeSH headings : Animals; Databases, Genetic; Genomics; Humans; Metamorphosis, Biological; Reproducibility of Results; Xenopus laevis / genetics
TL;DR:
133 new, high-quality illustrations of X. laevis development from fertilization to metamorphosis are presented, with additional views that were not available in the original collection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2021 journal article
Single-minded 2 is required for left-right asymmetric stomach morphogenesis
DEVELOPMENT, 148(17).
author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021
2020 review
The twists and turns of left-right asymmetric gut morphogenesis
[Review of ]. DEVELOPMENT, 147(19).
author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 16, 2020
2019 journal article
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data
BIRTH DEFECTS RESEARCH, 111(20), 1618–1632.
author keywords: birth defects; gene-environment interaction; genetics; intestinal atresia; sequence analysis
MeSH headings : Congenital Abnormalities / genetics; Congenital Abnormalities / prevention & control; Family; Gene-Environment Interaction; Humans; Exome Sequencing
TL;DR:
Successful sequencing of exomes from well-characterized NBDPS families indicated that this unique collection can be used to investigate the roles of genetic variation and gene-environment interaction effects in birth defect etiologies, providing a valuable resource for birth defect researchers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Vangl2 coordinates cell rearrangements during gut elongation
DEVELOPMENTAL DYNAMICS, 248(7), 569–582.
author keywords: Vangl2; endoderm; gut; Xenopus; morphogenesis; elongation
MeSH headings : Animals; Body Patterning; Cell Adhesion; Cell Movement; Cell Polarity; Endoderm / cytology; Intestines / anatomy & histology; Intestines / growth & development; Membrane Proteins / metabolism; Membrane Proteins / physiology; Morphogenesis; Xenopus Proteins / metabolism; Xenopus Proteins / physiology; Xenopus laevis / growth & development
TL;DR:
The embryonic gut tube undergoes extensive lengthening to generate the surface area required for nutrient absorption across the digestive epithelium in Xenopus, a process that concomitantly opens the gut lumen and facilitates epithelial morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2018 journal article
The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum
DEVELOPMENTAL BIOLOGY, 439(2), 80–91.
author keywords: Xenopus; Liver; Left-right asymmetry; Endoderm; Morphogenesis; Pitx2
MeSH headings : Animals; Body Patterning / genetics; Diverticulum / embryology; Diverticulum / metabolism; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental / genetics; Homeodomain Proteins / metabolism; Homeodomain Proteins / physiology; Liver / embryology; Liver / physiology; Morphogenesis / physiology; Transcription Factors / metabolism; Xenopus / embryology; Xenopus / physiology; Xenopus Proteins / metabolism; Xenopus Proteins / physiology
TL;DR:
Side-specific gain- and loss-of-function studies reveal that asymmetric expression of the left-right determinant Pitx2c elicits distinct epithelial morphogenesis events in the left side of the diverticulum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis
DEVELOPMENT, 144(15), 2764–2770.
author keywords: Acetylcholinesterase; Morphogenesis; Gut; Intestine; Fibronectin; Xenopus laevis
MeSH headings : Acetylcholine / metabolism; Acetylcholinesterase / genetics; Acetylcholinesterase / metabolism; Animals; Cell Adhesion / physiology; Embryo, Nonmammalian / metabolism; Endoderm / cytology; Endoderm / metabolism; Fibronectins / genetics; Fibronectins / metabolism; Immunohistochemistry; Nervous System / embryology; Nervous System / metabolism; Organogenesis / genetics; Organogenesis / physiology; RNA, Messenger / genetics; Xenopus laevis / embryology; Xenopus laevis / genetics; Xenopus laevis / metabolism
TL;DR:
A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified and has wide-reaching implications for development and toxicology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Stomach curvature is generated by left-right asymmetric gut morphogenesis
DEVELOPMENT, 144(8), 1477–1483.
author keywords: Left-right; Asymmetry; Stomach; Gut; Morphogenesis; Pitx2; Xenopus; Mouse
MeSH headings : Animals; Body Patterning; Endoderm / embryology; Endoderm / metabolism; Epithelium / embryology; Epithelium / metabolism; Homeodomain Proteins / metabolism; Mice; Rotation; Signal Transduction; Stomach / anatomy & histology; Stomach / embryology; Transcription Factors / metabolism; Xenopus / embryology
TL;DR:
It is shown that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself, and this findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Frogs as integrative models for understanding digestive organ development and evolution
[Review of ]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 51, 92–105.
author keywords: Embryo; Xenopus; Lepidobatrachus; Eleutherodactylous coqui; Gut; Specification; Morphogenesis; Evolution
MeSH headings : Animals; Biological Evolution; Calcium Signaling; Cell Communication; Digestive System / cytology; Digestive System / embryology; Endoderm / cytology; Endoderm / embryology; Gene Expression; Gene Expression Regulation, Developmental; Humans; Morphogenesis; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR:
The unparalleled experimental versatility of frog embryos make them excellent, integrative models for studying digestive organ development across multiple disciplines, including the regeneration or replacement of diseased organs, the etiology of digestive organ birth defects, and the evolution of specialized features of digestive anatomy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Budgett's frog (Lepidobatrachus laevis): A new amphibian embryo for developmental biology
DEVELOPMENTAL BIOLOGY, 405(2), 291–303.
author keywords: Lepidobatrachus; Xenopus; Amphibian; Embryo; Stages; Scaling
MeSH headings : Amphibians; Animals; Anura / embryology; Cell Lineage; Developmental Biology; Embryonic Development; Immunohistochemistry; Models, Animal; Morphogenesis; Organogenesis; Regeneration; Species Specificity; Xenopus laevis / physiology
TL;DR:
The Budgett's frog is described, an unusual species with eggs that are over twice the diameter of laboratory Xenopus, and embryos that can tolerate higher temperatures to develop into a tadpole four times more rapidly, which substantially accelerates the pace of experimentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs
Human Genetics, 133(9), 1139–1148.
MeSH headings : Animals; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Base Sequence; Case-Control Studies; Clathrin / antagonists & inhibitors; Clathrin / genetics; Codon / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Male; Molecular Sequence Data; Monomeric Clathrin Assembly Proteins / chemistry; Monomeric Clathrin Assembly Proteins / genetics; Monomeric Clathrin Assembly Proteins / metabolism; Mutagenesis, Insertional; Pedigree; Phosphatidylinositols / metabolism; Prospective Studies; Protein Conformation; Sequence Analysis, RNA; Sex Factors; Xenopus laevis / embryology
TL;DR:
A three-nucleotide exonic insertion in phosphatidylinositol-binding clathrin assembly protein (PICALM) that is associated with the development of SAS in Newfoundlands is identified and the role of PICALM in OFT development may aid in future molecular and genetic investigations into other congenital heart defects of various species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
CONSTRAINTS ON MAMMALIAN FORELIMB DEVELOPMENT: INSIGHTS FROM DEVELOPMENTAL DISPARITY
Evolution, 67(12), 3645–3652.
author keywords: Constraints; diversity; limb; mammal; morphometrics; ontogeny
MeSH headings : Animals; Evolution, Molecular; Forelimb / anatomy & histology; Forelimb / embryology; Horses / embryology; Horses / genetics; Mice / embryology; Mice / genetics; Opossums / embryology; Opossums / genetics; Swine / embryology; Swine / genetics
TL;DR:
Investigation of levels and patterns of morphological diversity (disparity) among the developing forelimbs of four mammals with diverse limb morphologies indicates that disparity slightly decreases or stays the same from the appearance of the limb ridge to the bud stage, and increases dramatically from the paddle through tissue regression stages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2013 journal article
Developmental origins of a novel gut morphology in frogs
EVOLUTION & DEVELOPMENT, 15(3), 213–223.
MeSH headings : Animals; Anura / embryology; Cell Lineage; Evolution, Molecular; Genetic Variation; Intestines / embryology; Morphogenesis; Phenotype; Phylogeny; Signal Transduction; Species Specificity; Thyroid Hormones / metabolism; Tretinoin / metabolism; Xenopus laevis / embryology
TL;DR:
The ancestral gut phenotype in Lepidobatrachus was recovered by performing a reverse chemical manipulation to upregulate RA signaling, providing strong evidence that modifications to this specific pathway promoted the emergence of a lineage‐specific phenotypic novelty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut
DEVELOPMENT, 140(7), 1457–1466.
author keywords: JNK; Rho kinase; Endoderm; Gut; Intestine; Morphogenesis; Xenopus
MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Body Patterning / physiology; Cell Adhesion / genetics; Cell Movement / genetics; Cell Movement / physiology; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gastrula / cytology; Gastrula / embryology; Gastrula / metabolism; Gene Expression Regulation, Developmental; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; JNK Mitogen-Activated Protein Kinases / genetics; JNK Mitogen-Activated Protein Kinases / metabolism; JNK Mitogen-Activated Protein Kinases / physiology; Microtubules / genetics; Microtubules / metabolism; Models, Biological; Permeability; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism
TL;DR:
It is shown that JNK activity is indispensable for the rearrangement of endoderm cells that underlies the elongation of the Xenopus gut tube, and sheds new light on the means by which intra- and intercellular forces are balanced to promote topological change, while preserving structural integrity, in numerous morphogenetic contexts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
Development, 139(2), 437–442.
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos
CHEMISTRY & BIOLOGY, 18(2), 252–263.
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Rac/JNK/dub regulates intercellular adhesive dynamics during gut morphogenesis
Developmental Biology, 356(1), 141.
TL;DR:
It is shown that the activity of Jun N-terminal kinase (JNK) is required for Xenopus gut morphogenesis, and data suggest that a Rac/JNK/dub pathway orchestrates tissue-elongating endoderm cell rearrangements during gut Morphogenesis by regulating intercellular adhesive dynamics.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut
DEVELOPMENT, 137(8), 1339–1349.
author keywords: Pitx1; Pitx2; Shroom; Apical constriction; Epithelium; Gut; Xenopus
MeSH headings : Animals; Base Sequence; Blastomeres / physiology; Cell Shape / genetics; Conserved Sequence; DNA Primers; Drosophila / anatomy & histology; Drosophila / physiology; Epithelial Cells / cytology; Epithelial Cells / physiology; Female; Gastrointestinal Tract / embryology; Gastrointestinal Tract / physiology; Gene Expression Regulation, Developmental; Genes, Reporter; Luciferases / genetics; Morphogenesis / physiology; Oligonucleotides, Antisense / pharmacology; Paired Box Transcription Factors / genetics; RNA, Messenger / genetics; Transcription Factors / genetics; Transcription Factors / physiology; Xenopus laevis / embryology
TL;DR:
It is shown in Xenopus that Shroom3 is essential for cell shape changes and morphogenesis in the developing vertebrate gut and thatShroom3 transcription in the gut requires the Pitx1 transcription factor and that ectopic expression of Pitx proteins is sufficient to induce Shrooms3-dependent cytoskeletal reorganization and epithelial cell shape change.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Heterotaxin: A novel TGF-beta signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos
Developmental Biology, 344(1), 526.
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a novel pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
Journal of the American Chemical Society, 132(44), 15644–15650.
MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Light activated modulation of protein activity (Lamp): A tool for spatiotemporal control of signaling components in living embryos
Developmental Biology, 331(2), 482.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2009 journal article
Morphogenesis of the Primitive Gut Tube Is Generated by Rho/ROCK/Myosin II-Mediated Endoderm Rearrangements
DEVELOPMENTAL DYNAMICS, 238(12), 3111–3125.
author keywords: gut; Xenopus; morphogenesis; endoderm, intercalation; elongation
MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Cell Polarity / genetics; Cell Shape / genetics; Embryo, Nonmammalian; Endoderm / cytology; Endoderm / embryology; Endoderm / metabolism; Gastrointestinal Diseases / congenital; Gastrointestinal Diseases / embryology; Gastrointestinal Tract / abnormalities; Gastrointestinal Tract / embryology; Gastrula / embryology; Gastrula / metabolism; Models, Biological; Morphogenesis / genetics; Nonmuscle Myosin Type IIB / genetics; Nonmuscle Myosin Type IIB / metabolism; Nonmuscle Myosin Type IIB / physiology; Signal Transduction / genetics; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism; rho-Associated Kinases / genetics; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism; rhoA GTP-Binding Protein / physiology
TL;DR:
The results suggest that the cellular and molecular events driving tissue elongation in the PGT are mechanistically analogous to those that function during gastrulation, but occur within a novel cylindrical geometry to generate an epithelial‐lined tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Small molecule-mediated “phenotypic engineering” reveals a role for retinoic acid in anuran gut evolution
Developmental Biology, 331(2), 400.
Source: Crossref
Added: August 28, 2020
2009 journal article
Wnt/planar cell polarity signaling controls endoderm cell rearrangements during the morphogenesis of the primitive gut tube
Developmental Biology, 331(2), 450.
Source: Crossref
Added: August 28, 2020
2008 journal article
Ancestral variation and the potential for genetic accommodation in larval amphibians: implications for the evolution of novel feeding strategies
EVOLUTION & DEVELOPMENT, 10(3), 316–325.
MeSH headings : Animals; Anura / anatomy & histology; Anura / genetics; Anura / physiology; Biological Evolution; Diet; Digestive System / anatomy & histology; Feeding Behavior / physiology; Genetic Variation; Larva / anatomy & histology; Larva / physiology; Phenotype; Phylogeny; Species Specificity
TL;DR:
Evaluated whether gut plasticity preceded and promoted the evolution of a novel feeding strategy in spadefoot toad tadpoles, finding that shrimp induced a range of phenotypes in Scaphiopus that were not produced with detritus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Basolumenal endoderm intercalation: A geometrically unique execution of convergent extension during gut tube elongation
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Heterotaxin: A novel pyridine compound that perturbs left–right asymmetric organ morphogenesis
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Small molecule-mediated “phenotypic engineering” reveals a role for retinoic acid in anuran gut evolution
Developmental Biology, 319(2), 497–498.
Source: Crossref
Added: August 28, 2020
2007 journal article
Rho GTPase signaling directs the late stage morphogenesis of the Xenopus digestive system
Developmental Biology, 306(1), 441.
Source: Crossref
Added: August 28, 2020
2006 journal article
Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis
Developmental Dynamics, 235(8), 2266–2275.
author keywords: retinoic acid; RALDH2; CYP26A1; gut; looping; malrotation; Xenopus; biliary atresia; annular pancreas
MeSH headings : Aldehyde Dehydrogenase 1 Family; Aldehyde Oxidase / genetics; Animals; Body Patterning; Cytochrome P-450 Enzyme System / genetics; Digestive System / growth & development; Digestive System / metabolism; Morphogenesis; Oxidoreductases / genetics; Receptors, Retinoic Acid / metabolism; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Retinoids / metabolism; Signal Transduction; Xenopus Proteins / genetics; Xenopus laevis / genetics; Xenopus laevis / growth & development; Xenopus laevis / metabolism
TL;DR:
It is shown that the genes for retinaldehyde dehydrogenase and a retinoic acid hydroxylase are expressed in complementary patterns in the Xenopus gut during looping, likely to play a critical role in asymmetric gut tube morphogenesis and may underlie the etiology of several clinically relevant defects in the digestive system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2003 journal article
Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis
Development Genes and Evolution, 213(8), 390–398.
author keywords: Xenopus; heart; embryology
MeSH headings : Animals; Body Patterning; Embryo, Nonmammalian; Heart / embryology; Homeodomain Proteins / metabolism; Morphogenesis; Myocardium / metabolism; Transcription Factors / metabolism; Xenopus / anatomy & histology; Xenopus / embryology; Xenopus / genetics
TL;DR:
A bilateral heart-specific fate map of the left and right contributions to the developing heart in the Xenopus embryo is constructed and it is revealed that this Pitx2-expressing region is fated to form the inner curvature of the heart loop, the left atrioventricular canal, and the dorsal aspect of theleft atrium.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2003 journal article
Left-right asymmetric morphogenesis in theXenopus digestive system
Developmental Dynamics, 228(4), 672–682.
author keywords: asymmetry; gut; left; morphogenesis; right; Pitx2; Xenopus
MeSH headings : Animals; Body Patterning; Cell Division; Cell Lineage; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / embryology; Gastrula / metabolism; Homeodomain Proteins / biosynthesis; Immunohistochemistry; In Situ Hybridization; Mesoderm / metabolism; Microscopy, Fluorescence; Morphogenesis; RNA, Messenger / metabolism; Time Factors; Tissue Distribution; Transcription Factors / biosynthesis; Xenopus laevis / embryology
TL;DR:
The roles of the left and right sides of the Xenopus embryo during the development of anatomic asymmetries in the digestive system are compared to provide insight into the nature of symmetry‐breaking morphogenetic events during left–right asymmetric organ development.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2000 journal article
Evolutionary relationships between the amphibian, avian, and mammalian stomachs
Evolution and Development, 2(6), 348–359.
MeSH headings : Animals; Biological Evolution; Birds / anatomy & histology; Chick Embryo; Female; In Situ Hybridization; Mammals / anatomy & histology; Mice; Pregnancy; Stomach / anatomy & histology; Xenopus laevis / anatomy & histology
TL;DR:
The global patterning of the gut is remarkably similar among the different vertebrate lineages, and the distinct compartments of gene expression that are found in the gut be necessary for the unique morphological specializations that distinguish the stomachs from terrestrial vertebrates.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
1997 journal article
Organizer Induction Determines Left–Right Asymmetry inXenopus
Developmental Biology, 189(1), 68–78.
MeSH headings : Animals; Embryonic Induction; Female; Heart / embryology; Xenopus laevis / embryology
TL;DR:
It is shown that the induction of dorsal organizing centers in the embryo can orient left-right asymmetry, and this results indicate that LR asymmetry is locally oriented as a consequence of Wnt signaling through beta-catenin and Siamois.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
1997 journal article
Two molecular models of initial left-right asymmetry generation
Medical Hypotheses, 49(5), 429–435.
MeSH headings : Animals; Body Patterning / genetics; Connexin 43 / physiology; Dyneins / physiology; Humans; Models, Molecular
TL;DR:
Two models are presented, significantly supported by previous findings, which hypothesize that dynein asymmetrically localizes LR determinants in individual cells to establish cell-autonomous LR biasing, and asymmetric activity of Cx43 gap junctions within key cells sets up electric potentials in multicellular fields, thus establishing large-scale LR asymmetry.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
1996 journal article
Endoderm and Cardiogenesis
Trends in Cardiovascular Medicine, 6(7), 211–216.
TL;DR:
The ability of the endoderm to generate a beating heart from tissues fated to form other cell types suggests that endoderman may also be involved in the initial specification of the early heart field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
1995 journal article
An inductive role for the endoderm in Xenopus cardiogenesis
Development, 121, 515–523.
Source: NC State University Libraries
Added: September 9, 2019
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