Jon M. Rhoads

Works (9)

Updated: March 10th, 2025 12:14

2008 journal article

Arginine Activates Intestinal p70S6k and Protein Synthesis in Piglet Rotavirus Enteritis

The Journal of Nutrition, 138(1), 24–29.

By: B. Corl n, J. Odle n , X. Niu*, A. Moeser*, L. Gatlin n, O. Phillips n, A. Blikslager* , J. Rhoads*

MeSH headings : Animals; Arginine / pharmacology; Dietary Supplements; Enteritis / blood; Enteritis / metabolism; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / virology; Jejunum / pathology; Protein Biosynthesis / drug effects; Ribosomal Protein S6 Kinases, 70-kDa / metabolism; Rotavirus Infections / enzymology; Rotavirus Infections / metabolism; Sirolimus / pharmacology; Swine / metabolism; Swine / virology
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Virus-based gene therapy research
TL;DR: It is concluded that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70( S6k)-independent mechanism. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 article

Role of mTOR signaling in intestinal cell migration

Rhoads, J. M., Niu, X., Odle, J., & Graves, L. M. (2006, May 18). American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 291, pp. G510–517.

By: J. Rhoads*, X. Niu, J. Odle*  & L. Graves

Contributors: J. Rhoads*, X. Niu, J. Odle*  & L. Graves

author keywords: insulin-like growth factor-1; arginine; p70 s6 kinase; extracellular signal-regulated kinase-2; rapamycin
MeSH headings : Animals; Arginine / metabolism; Cell Line; Cell Movement / physiology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Intestines / physiology; Protein Kinases / metabolism; Rats; Signal Transduction / physiology; TOR Serine-Threonine Kinases
topics (OpenAlex): PI3K/AKT/mTOR signaling in cancer; Polyamine Metabolism and Applications; Liver physiology and pathology
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1998 article

Cross-Linking and Disulfide Bond Formation of Introduced Cysteine Residues Suggest a Modified Model for the Tertiary Structure of URF13 in the Pore-Forming Oligomers

Rhoads, D. M., Brunner-Neuenschwander, B., Levings, C. S., & Siedow, J. N. (1998, June 1). Archives of Biochemistry and Biophysics.

By: D. Rhoads n, B. Brunner-Neuenschwander*, C. Levings n & J. Siedow*

author keywords: ligand-gated channel; pore-forming; receptor; URF13; T-toxin; cytoplasmic male sterility; pathotoxin
MeSH headings : Amino Acid Sequence; Cross-Linking Reagents / chemistry; Cysteine / chemistry; Cysteine / genetics; Diamide / pharmacology; Dicyclohexylcarbodiimide / pharmacology; Disulfides / chemistry; Maleimides / chemistry; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins / chemistry; Plant Proteins / genetics; Protein Structure, Tertiary; Sulfhydryl Compounds / chemistry; Threonine / genetics; Zea mays
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Mitochondrial Function and Pathology; DNA Repair Mechanisms
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13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

L-Glutamine and Transforming Growth Factor-α Enhance Recovery of Monoacylglycerol Acyltransferase and Diacylglycerol Acyltransferase Activity in Porcine Postischemic Ileum

Pediatric Research, 43(2), 227–233.

By: N. Ahdieh, A. Blikslager n , B. Bhat*, R. Coleman *, R. Argenzio n & J. Rhoads*

MeSH headings : Acyltransferases / metabolism; Animals; Diacylglycerol O-Acyltransferase; Duodenum / enzymology; Glutamine / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / enzymology; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Jejunum / enzymology; Male; Swine; Transforming Growth Factor alpha / pharmacology
topics (OpenAlex): Pancreatic function and diabetes; Diet, Metabolism, and Disease; Lipid metabolism and biosynthesis
TL;DR: It is shown that intestinal MGAT and DGAT activities decrease after ischemic damage, yet recover rapidly in bowel exposed to Gln and/or TGF-α, which could improve the efficacy of enteral feeding in infants recovering from bowel damage. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018

1997 article

Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?

Blikslager, A. T., Roberts, M. C., Rhoads, J. M., & Argenzio, R. A. (1997, May 1). Surgery.

By: A. Blikslager n , M. Roberts n, J. Rhoads n & R. Argenzio n

MeSH headings : Animals; Female; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestines / blood supply; Intestines / enzymology; Ischemia / complications; Ischemia / metabolism; Male; Peroxidases / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Swine; Xanthine Dehydrogenase / metabolism; Xanthine Oxidase / metabolism
topics (OpenAlex): Cardiac Ischemia and Reperfusion; Organ Transplantation Techniques and Outcomes; Acute Kidney Injury Research
TL;DR: Reperfusion injury may not play an important role in intestinal injury under conditions of complete mesenteric ischemia and low-flow states in the pig, which may result from low xanthine oxidase-xanthine dehydrogenase levels, which are similar to those found in the human being. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 article

L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases

Rhoads, J. M., Argenzio, R. A., Chen, W., Rippe, R. A., Westwick, J. K., Cox, A. D., … Brenner, D. A. (1997, May 1). American Journal of Physiology-Gastrointestinal and Liver Physiology.

By: J. Rhoads*, R. Argenzio*, W. Chen*, R. Rippe*, J. Westwick*, A. Cox *, H. Berschneider*, D. Brenner *

author keywords: Jun nuclear kinase; IEC-6 cells; enterocyte; epidermal growth factor; c-Jun; extracellular signal-related kinase; Elk-1; diarrhea; insulin-like growth factor I
MeSH headings : Animals; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cell Division / drug effects; DNA-Binding Proteins / metabolism; Enzyme Activation; Epidermal Growth Factor / pharmacology; Genes, Reporter; Glutamine / pharmacology; Intestines / cytology; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun / genetics; RNA, Messenger / metabolism; Rats; Swine; Transcription Factor AP-1 / physiology; Transcription, Genetic / drug effects
topics (OpenAlex): Clinical Nutrition and Gastroenterology; Growth Hormone and Insulin-like Growth Factors; Cancer, Hypoxia, and Metabolism
TL;DR: Gln may be a unique nutrient for enterocytes, capable of dual signaling and augmenting the effects of growth factors that govern cellular proliferation and repair. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway

Journal of Pharmacology and Experimental Therapeutics, 283(2), 692–697.

By: R. Argenzio, M. Armstrong, A. Blikslager  & J. Rhoads

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.

Journal of Clinical Investigation, 100(8), 1928–1933.

By: A. Blikslager n , M. Roberts n, J. Rhoads* & R. Argenzio n

author keywords: intestinal mucosa; ischemia; cAMP; calcium; tight junctions
MeSH headings : Animals; Cytoprotection; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Epithelium / drug effects; Epithelium / metabolism; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; In Vitro Techniques; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Inulin / metabolism; Male; Permeability / drug effects; Reperfusion Injury / drug therapy; Swine
topics (OpenAlex): Inflammatory mediators and NSAID effects; Helicobacter pylori-related gastroenterology studies; Enhanced Recovery After Surgery
TL;DR: It is concluded that PGE2 and PGI2 have a synergistic role in restoration of intestinal barrier function by increasing intracellular cAMP and Ca2+, respectively, which in turn signal cytoskeletal-mediated tight junction closure. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

1997 article

Reactive Oxygen Metabolites in Piglet Cryptosporidiosis

Argenzio, R. A., & Rhoads, J. M. (1997, April 1). Pediatric Research.

By: R. Argenzio n & J. Rhoads*

MeSH headings : Animals; Animals, Newborn; Biological Transport / physiology; Catalase / metabolism; Cryptosporidiosis / complications; Cryptosporidiosis / drug therapy; Cryptosporidiosis / metabolism; Diarrhea / drug therapy; Diarrhea / etiology; Diarrhea / metabolism; Electrolytes / metabolism; Ileum / metabolism; Indomethacin / therapeutic use; Lipid Peroxidation / physiology; Malondialdehyde / metabolism; Prostaglandins / metabolism; Reactive Oxygen Species / metabolism; Swine; Tetrodotoxin / therapeutic use
topics (OpenAlex): Parasitic Infections and Diagnostics; Coccidia and coccidiosis research
TL;DR: There is evidence of increased ROM production in cryptosporidial infection and that intestinal PG synthesis and inhibited NaCl absorption may be mediated partially by ROM in this model, suggesting additional, cooperative factors are likely needed to induce the alterations in ion transport seen in this infection. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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