Yan Cao

Works (12)

Updated: February 10th, 2025 14:29

2010 journal article

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Toxicology and Applied Pharmacology, 245(3), 335–343.

By: R. Casabar, P. Das, G. DeKrey, C. Gardiner, Y. Cao, R. Rose, A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Lysine 419 targets human glucocorticoid receptor for proteasomal degradation

Steroids, 75(12), 1016–1023.

By: A. Wallace, Y. Cao, S. Chandramouleeswaran & J. Cidlowski

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes

Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, December 15). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 164, pp. 200–214.

By: P. Das n, Y. Cao n, N. Cherrington *, E. Hodgson n & R. Rose n

author keywords: fipronil; human hepatic and HepG2 cells; CYP3A4; CYP2B6; CYP1A1; cytotoxicity; apoptosis
MeSH headings : Caspase 3 / metabolism; Caspase 7 / metabolism; Cell Survival / drug effects; Cells, Cultured; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Gene Expression Regulation; Hepatocytes / drug effects; Hepatocytes / enzymology; Humans; Isoenzymes / genetics; Isoenzymes / metabolism; Pyrazoles / chemistry; Pyrazoles / pharmacology; RNA, Messenger / genetics; Sulfur / chemistry; Transcription, Genetic / genetics; fas Receptor / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Insect and Pesticide Research; Pesticide Exposure and Toxicity
TL;DR: The results indicate both that HepG2 cells and primary human hepatocytes are sensitive to the cytotoxic effects of fipronil and caspase-3/7 in concurrence with compromised ATP production and viability are attributed to apoptotic cell death. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

Development of an ELISA for the detection of bromoxynil in water

ENVIRONMENT INTERNATIONAL, 31(1), 33–42.

By: Y. Cao*, Y. Lu*, S. Long n, J. Hong* & G. Sheng*

author keywords: ELISA; bromoxynil; 2,6-dibromo-4-cyanophenoxyacetic acid; cross-reactivity; water analysis
MeSH headings : Animals; Bromobenzenes / chemical synthesis; Bromobenzenes / immunology; Cross Reactions; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay / methods; Female; Haptens / immunology; Herbicides / analysis; Herbicides / immunology; Hydrogen-Ion Concentration; Immune Sera / biosynthesis; Immune Sera / immunology; Immunization; Male; Nitriles / analysis; Nitriles / immunology; Polysorbates; Rabbits; Reproducibility of Results; Rivers / chemistry; Water / analysis
topics (OpenAlex): Pesticide Residue Analysis and Safety; Pharmacological Effects and Assays; Analytical chemistry methods development
TL;DR: The proposed ELISA turned out to be a powerful tool for monitoring of residual bromoxynil in water samples at trace level and showed little cross-reactivity with 2,6-dibromophenol and brom oxynil octanoate ester, but showed no cross- reactivity with other herbicides. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pesticide metabolism in humans, including polymorphisms

Scandinavian Journal of Work, Environment & Health, 31, 156–163.

By: R. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos

CHEMICO-BIOLOGICAL INTERACTIONS, 141(3), 229–241.

By: J. Tang n, Y. Cao n, R. Rose n & E. Hodgson n

author keywords: carbaryl; human lifer microsomes; metabolism
MeSH headings : Adult; Carbaryl / metabolism; Cells, Cultured; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation / drug effects; Insecticides / metabolism; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver; Molecular Structure
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Pesticide Exposure and Toxicity
TL;DR: In vitro metabolic activities of human liver microsomes (HLM) and human cytochrome P450 (CYP) isoforms toward carbaryl were investigated and the production of carbaryl methylol was primarily the result of metabolism by CYP2B6. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes

Drug Metabolism and Disposition, 29(9), 1201–1204.

By: J. Tang, Y. Cao, R. Rose, A. Brimfield, D. Dai, J. Goldstein, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 70(3), 127–141.

By: D. Dai*, Y. Cao n, G. Falls*, P. Levi n, E. Hodgson n & R. Rose n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies
TL;DR: It is demonstrated that structurally diverse environmental chemicals including mirex, 2,2-Bis( p -chlorophenyl)-1,1-dichloroethylene (DDE), vinclozolin, and flutamide are capable of inducing several mouse liver CYP isozymes that may significantly impact testosterone metabolism and this may be a contributing factor in their antiandrogenic effects. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 journal article

Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(2), 118–120.

By: E. Hodgson n, R. Rose n, Y. Cao n, S. Dehal* & D. Kupfer*

author keywords: flavin-containing monooxygenase; FMO; FMO isoforms; tamoxifen; human; mouse
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Receptor Mechanisms and Signaling; Estrogen and related hormone effects
TL;DR: The Km value for tamoxifen is 1.2 mM for mouse FMO1 (human F MO1 is not expressed in adults) and 1.4 mM for human FMO3, with no detectable activity being expressed toward tamoxIFen by FMO5 from either mouse or human, derived from experiments using 3H‐tamox ifen as substrate in which the product, tamoxIfen N‐oxide, was measured directly. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

Flavin-containing monooxygenase and cytochrome P450 mediated metabolism of pesticides: from mouse to human

Reviews in Toxicology, 2(1998), 231–243.

By: E. Hodgson, N. Cherrington, S. Coleman, S. Liu, J. Falls, Y. Cao, J. Goldstein, R. Rose

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5

XENOBIOTICA, 28(7), 673–682.

By: N. Cherrington n, Y. Cao n, J. Cherrington n, R. Rose n & E. Hodgson n

MeSH headings : Adult; Animals; Female; Humans; Liver / embryology; Liver / metabolism; Male; Mice; Microsomes, Liver / metabolism; Middle Aged; Oxygenases / biosynthesis; Rats; Sex Characteristics; Species Specificity
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Effects and risks of endocrine disrupting chemicals
TL;DR: The mouse and rat exhibit substantial differences in the gender expression of flavin-containing monooxygenase (FMO) forms, and Methimazole, imipramine and thiobenzamide are much better substrates for FMO1 than for F MO3 or FMO5. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids

Falls, J. G., Ryu, D. Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 15). ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 342, pp. 212–223.

By: J. Falls n, D. Ryu n, Y. Cao n, P. Levi n & E. Hodgson n

author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone
MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Estrogen and related hormone effects; Neuroscience and Neuropharmacology Research
TL;DR: In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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