Karen Alyse Yokley

Works (2)

Updated: July 5th, 2023 15:55

2007 journal article

Sensory irritation response in rats: Modeling, analysis and validation

BULLETIN OF MATHEMATICAL BIOLOGY, 70(2), 555–588.

By: K. Yokley n, H. Tran n  & P. Schlosser*

author keywords: sensory response; PBPK; formaldehyde
MeSH headings : Animals; Computer Simulation; Dose-Response Relationship, Drug; Feedback, Physiological; Formaldehyde / toxicity; Gases / toxicity; Hypoventilation / etiology; Hypoventilation / physiopathology; Hypoventilation / veterinary; Inhalation Exposure; Irritants / toxicity; Models, Biological; Neuroepithelial Cells / drug effects; Neuroepithelial Cells / physiology; Pulmonary Ventilation / drug effects; Rats; Respiration / drug effects; Respiratory System / drug effects; Respiratory System / innervation; Respiratory System / physiopathology; Sensation / drug effects; Sensation / physiology; Trigeminal Nerve / drug effects; Trigeminal Nerve / physiopathology
TL;DR: A mathematical model is created to describe how the presence of irritants affects respiration in the rat and predicts the formaldehyde data well, and is thought to be a reasonable description of the physiological system of sensory irritation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Physiologically-based pharmacokinetic modeling of benzene in humans: A Bayesian approach

RISK ANALYSIS, 26(4), 925–943.

By: K. Yokley n, H. Tran* , K. Pekari, S. Rappaport *, V. Riihimaki, N. Rothman, S. Waidyanatha *, P. Schlosser *

author keywords: Bayesian; benzene; dosimetry; human; metabolism; PBPK; variability
TL;DR: A human physiologically‐based pharmacokinetic (PBPK) model that quantifies tissue doses of benzene and its key metabolites, benzene oxide, phenol, and hydroquinone after inhalation and oral exposures is described. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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