Jessica P. Ryman-Rasmussen

Works (9)

Updated: July 5th, 2023 15:55

2009 journal article

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 43(2), 142–151.

By: M. Cesta n, J. Ryman-Rasmussen n, D. Wallace*, T. Masinde*, G. Hurlburt*, A. Taylor n, J. Bonner n 

author keywords: carbon nanotubes; inflammation; lipopolysaccharide; fibrosis; growth factors
MeSH headings : Animals; Bacteria / metabolism; Fibroblasts / metabolism; Fibrosis; Inflammation; Lipopolysaccharides / metabolism; Macrophages / metabolism; Male; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Platelet-Derived Growth Factor / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; Soot / chemistry
TL;DR: The data suggest that LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasingPDGF-Ralpha on pulmonary fibroblasts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Inhaled carbon nanotubes reach the subpleural tissue in mice

NATURE NANOTECHNOLOGY, 4(11), 747–751.

By: J. Ryman-Rasmussen n, M. Cesta n, A. Brody n, J. Shipley-Phillips n, J. Everitt  n, E. Tewksbury*, O. Moss *, B. Wong* ...

MeSH headings : Aerosols / adverse effects; Animals; Immunity / drug effects; Inhalation Exposure / analysis; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Pleura / drug effects; Pleura / immunology; Pleura / ultrastructure; Pulmonary Fibrosis / chemically induced
TL;DR: It is shown that multi-walled carbon nanotubes reach the sub-pleura in mice after a single inhalation exposure of 30 mg/m3 for 6 hours and it is suggested that minimizing inhalation of nanot tubes during handling is prudent until further long term assessments are conducted. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(3), 349–358.

By: J. Ryman-Rasmussen n, E. Tewksbury*, O. Moss *, M. Cesta n, B. Wong * & J. Bonner n 

author keywords: carbon nanotubes; asthma; fibrosis; lung
MeSH headings : Administration, Inhalation; Aerosols; Animals; Asthma / chemically induced; Asthma / immunology; Asthma / pathology; Bronchoalveolar Lavage Fluid / cytology; Fibrosis / chemically induced; Fibrosis / immunology; Fibrosis / pathology; Humans; Interleukin-13 / immunology; Lung / cytology; Lung / immunology; Lung / pathology; Macrophages / cytology; Macrophages / metabolism; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Ovalbumin / immunology; Particle Size; Platelet-Derived Growth Factor / immunology; Random Allocation; Transforming Growth Factor beta1 / immunology
TL;DR: It is indicated that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled multiwalled carbon nanotubes, and combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airways fibrosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop

JOURNAL OF IMMUNOLOGY, 180(6), 4200–4207.

By: A. Antao-Menezes*, E. Turpin*, P. Bost n, J. Ryman-Rasmussen n & J. Bonner n 

MeSH headings : Autocrine Communication / drug effects; Autocrine Communication / immunology; Cell Line; Culture Media, Conditioned; Enzyme Inhibitors / pharmacology; Fibroblasts / drug effects; Fibroblasts / enzymology; Fibroblasts / immunology; Fibroblasts / metabolism; Humans; Hydrogen Peroxide / metabolism; Interferon-beta / physiology; Intracellular Fluid / drug effects; Intracellular Fluid / immunology; Intracellular Fluid / metabolism; Lung / drug effects; Lung / enzymology; Lung / immunology; Lung / metabolism; NADPH Oxidases / antagonists & inhibitors; NADPH Oxidases / physiology; Phosphorylation; Reactive Oxygen Species / metabolism; STAT1 Transcription Factor / metabolism; STAT1 Transcription Factor / physiology; Signal Transduction / drug effects; Signal Transduction / immunology; Vanadium Compounds / pharmacology; Xanthine Oxidase / physiology
TL;DR: Fibroblasts play a role in the innate immune response to vanadium-induced oxidative stress by synthesizing IFN-β and activating STAT-1 to cause growth arrest and increase levels of CXCL10, a potent antifibrotic factor. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators

NANO LETTERS, 7(5), 1344–1348.

By: J. Ryman-Rasmussen n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: J. Ryman-Rasmussen n, J. Riviere n & N. Monteiro-Riviere n 

MeSH headings : Amines / metabolism; Carboxylic Acids / metabolism; Cells, Cultured; Nanoparticles; Polyethylene Glycols / metabolism; Quantum Dots; Skin / cytology; Skin / metabolism
TL;DR: Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions that are important for understanding and controlling interactions of untargeted QD with cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin

NANO LETTERS, 7(1), 155–160.

By: J. Rouse n, J. Yang  n, J. Ryman-Rasmussen n, A. Barron  n & N. Monteiro-Riviere n 

Contributors: J. Rouse n, J. Yang  n, J. Ryman-Rasmussen n, A. Barron  n & N. Monteiro-Riviere n 

MeSH headings : Amino Acids / chemistry; Fluorescein-5-isothiocyanate; Fullerenes / chemistry; Microscopy, Confocal; Nanoparticles / chemistry; Nuclear Localization Signals; Peptides / pharmacokinetics; Skin Absorption
TL;DR: TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 127(1), 143–153.

By: J. Ryman-Rasmussen n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: J. Ryman-Rasmussen n, J. Riviere n & N. Monteiro-Riviere n 

MeSH headings : Cells, Cultured; Drug Delivery Systems / adverse effects; Epidermis; Humans; Interleukin-1 / metabolism; Interleukin-10 / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Irritants / toxicity; Keratinocytes; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles / administration & dosage; Nanoparticles / toxicity; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Human epidermal keratinocytes (HEKs) were used to assess if QDs with different surface coatings would cause differential effects on HEK cytotoxicity, proinflammatory cytokine release, and cellular uptake, and data indicate that QD surface coating is a primary determinant of cytot toxicity and immunotoxicity in HEKs, which is consistent across size. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 chapter

Toxicology of nanomaterials

In Biological concepts and techniques in toxicology: An integrated approach (pp. 217–233). New York: Taylor & Francis.

By: N. Monteiro-Riviere  & J. Ryman-Rasmussen

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Transcription inhibition using oligonucleotide-modified gold nanoparticles

BIOCONJUGATE CHEMISTRY, 17(5), 1178–1183.

By: C. Agbasi-Porter n, J. Ryman-Rasmussen n, S. Franzen n  & D. Feldheim n

MeSH headings : Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gold / chemistry; Gold / metabolism; Humans; Metal Nanoparticles / chemistry; Oligonucleotides / chemistry; Oligonucleotides / metabolism; Promoter Regions, Genetic; Transcription, Genetic; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR: The competitive binding and inhibition of T7 RNA polymerase due to specific interactions on the nanoparticle surface represents a transcription factor decoy approach in a model system and provides a basis for determining the accessibility of binding sites on nanoparticle surfaces for applications involving cell targeting or the use of nanoparticles as binding agents in solution. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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