Prashant K. Nighot
Works (15)
Updated: August 20th, 2023 21:19
2016 conference paper
Parametric study of a fluidic artificial muscle actuated electrohydraulic system
Proceedings of the asme conference on smart materials adaptive.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion
PLOS ONE, 10(9), e0138174.
Ed(s): A. Guerrero-Hernandez
MeSH headings : Animals; Biological Transport; CLC-2 Chloride Channels; Cell Count; Chloride Channels / genetics; Cytoplasmic Vesicles / metabolism; Digestion / genetics; Digestion / physiology; Fluorescent Antibody Technique; Gastric Acid / metabolism; H(+)-K(+)-Exchanging ATPase / biosynthesis; H(+)-K(+)-Exchanging ATPase / metabolism; Mice; Mice, Knockout; Microscopy, Electron; Parietal Cells, Gastric / metabolism; Parietal Cells, Gastric / ultrastructure; Pepsinogen A / metabolism
journals.plos.org (publisher PDF)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2013 journal article
Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis
Inflammatory Bowel Diseases, 19(13), 2867–2877.
author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection
Comparative Immunology, Microbiology and Infectious Diseases, 35(1), 63–69.
author keywords: Astrovirus; Enterocyte; Turkey; Inducible nitric oxide; Innate immunity
MeSH headings : Amino Acid Sequence; Animals; Astroviridae Infections / enzymology; Astroviridae Infections / veterinary; Astroviridae Infections / virology; Avastrovirus / physiology; Avian Proteins / genetics; Avian Proteins / metabolism; Bird Diseases / enzymology; Bird Diseases / virology; Enterocytes / enzymology; Enterocytes / pathology; Enterocytes / virology; Gene Expression; HEK293 Cells; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Lentivirus / genetics; Molecular Sequence Data; Nitric Oxide / biosynthesis; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phylogeny; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Transfection; Turkeys
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin
American Journal of Physiology-Cell Physiology, 302(1), C178–C187.
author keywords: Caco-2; epithelium; intestine; permeability
MeSH headings : CLC-2 Chloride Channels; Caco-2 Cells; Caveolae / metabolism; Caveolae / physiology; Cell Communication / physiology; Chloride Channels / metabolism; Chloride Channels / physiology; Humans; Intracellular Fluid / metabolism; Intracellular Fluid / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Occludin; Protein Transport / physiology; Tight Junctions / metabolism; Tight Junctions / physiology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2010 journal article
Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression
Virology, 401(2), 146–154.
author keywords: Astrovirus; Viral enteritis; Malabsorption diarrhea; Sodium/hydrogen exchanger; Intestinal electrophysiology; Turkey
MeSH headings : Actins / metabolism; Animals; Astroviridae Infections / pathology; Astroviridae Infections / veterinary; Avastrovirus / pathogenicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Gene Expression; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Poultry Diseases / pathology; Poultry Diseases / virology; Sodium / metabolism; Sodium-Hydrogen Exchangers / analysis; Turkeys
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2010 journal article
ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction
American Journal of Physiology-Gastrointestinal and Liver Physiology, 299(2), G449–G456.
author keywords: myosin light chain kinase; chloride channel; mannitol flux
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / antagonists & inhibitors; Chloride Channels / deficiency; Chloride Channels / metabolism; Chlorides / pharmacology; Electrophysiological Phenomena; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Ileum / ultrastructure; In Vitro Techniques; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Mannitol / pharmacokinetics; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Electron, Scanning; Microvilli / ultrastructure; Myosin-Light-Chain Kinase / metabolism; Permeability; Phenotype; Tight Junctions / ultrastructure; Zinc Compounds / pharmacology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2010 journal article
TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium
The Journal of Immunology, 185(8), 4729–4737.
MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2009 journal article
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum
Experimental Cell Research, 315(1), 110–118.
author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2009 journal article
Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates
STEM CELLS, 27(6), 1255–1264.
author keywords: Reprogramming; Nuclear transfer; Embryonic stem cells; Primates
MeSH headings : Animals; Cell Differentiation; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Epigenesis, Genetic; Female; Fibroblasts / cytology; Gene Expression; Macaca mulatta; Nuclear Transfer Techniques; Oocytes / cytology; Pluripotent Stem Cells / cytology; Reverse Transcriptase Polymerase Chain Reaction
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine
World Journal of Gastroenterology, 14(39), 6012.
author keywords: Intestinal ischemia; Barrier function; Permeability; Laxative; Polyethylene Glycol
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Animals; Cell Membrane Permeability / drug effects; Cell Membrane Permeability / physiology; Chloride Channel Agonists; Disease Models, Animal; Epithelial Cells / drug effects; Epithelial Cells / physiology; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Laxatives / pharmacology; Lubiprostone; Male; Mannitol / metabolism; Polyethylene Glycols / pharmacology; Recovery of Function / drug effects; Reperfusion Injury / pathology; Reperfusion Injury / physiopathology; Swine
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2008 journal article
Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function
American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4), G791–G797.
author keywords: tight junction; intestinal permeability; ischemia; Na(+)/H(+) exchange
MeSH headings : Animals; Claudin-1; Intestinal Mucosa / physiopathology; Intestine, Small / blood supply; Ischemia / physiopathology; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Permeability; Phosphorylation; Sodium-Hydrogen Exchangers / genetics; Sodium-Hydrogen Exchangers / physiology; Tight Junctions / metabolism; Tight Junctions / ultrastructure
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2007 journal article
Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs
American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2), G413–G421.
author keywords: stress; barrier function; corticotropin releasing factor; tryptase
MeSH headings : Aging / metabolism; Animals; Cell Degranulation / drug effects; Colon, Ascending / drug effects; Colon, Ascending / metabolism; Corticotropin-Releasing Hormone / blood; Cromolyn Sodium / pharmacology; Cromolyn Sodium / therapeutic use; Electric Impedance; Gastrointestinal Agents / pharmacology; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / enzymology; Gastrointestinal Diseases / metabolism; Gastrointestinal Diseases / prevention & control; Gastrointestinal Diseases / psychology; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Secretions / metabolism; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / enzymology; Mast Cells / metabolism; Permeability; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / complications; Stress, Psychological / enzymology; Stress, Psychological / metabolism; Swine; Time Factors; Tryptases / metabolism; Up-Regulation; Weaning
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2007 journal article
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G647–G656.
author keywords: ischemia; type 2 chloride channels; repair
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Alprostadil / therapeutic use; Animals; Bumetanide / pharmacology; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels / antagonists & inhibitors; Chlorides / pharmacology; Colon / blood supply; Colon / drug effects; Colon / physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator / antagonists & inhibitors; Dinoprostone / pharmacology; Electric Impedance; Electrophysiology; Fatty Acids / pharmacology; Fatty Acids / therapeutic use; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Lubiprostone; Male; Mannitol / metabolism; Membrane Proteins / metabolism; Occludin; Permeability; Recovery of Function / drug effects; Sus scrofa; Urea / analogs & derivatives; Urea / pharmacology; Zinc Compounds / pharmacology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2006 journal article
Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine
American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.
author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
