Kathleen A. Ryan

Works (6)

Updated: July 8th, 2023 21:16

2008 journal article

ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum

Experimental Cell Research, 315(1), 110–118.

By: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n 

Contributors: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n 

author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
TL;DR: A pivotal role is demonstrated in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury in ClC-2(-/-) mice. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs

American Journal of Veterinary Research, 69(4), 457–464.

By: J. Wooten n, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles  n

Contributors: J. Wooten n, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles  n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
TL;DR: In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function

American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4), G791–G797.

By: A. Moeser n, P. Nighot n, K. Ryan n, J. Simpson*, L. Clarke * & A. Blikslager n 

Contributors: A. Moeser n, P. Nighot n, K. Ryan n, J. Simpson*, L. Clarke * & A. Blikslager n 

author keywords: tight junction; intestinal permeability; ischemia; Na(+)/H(+) exchange
MeSH headings : Animals; Claudin-1; Intestinal Mucosa / physiopathology; Intestine, Small / blood supply; Ischemia / physiopathology; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Permeability; Phosphorylation; Sodium-Hydrogen Exchangers / genetics; Sodium-Hydrogen Exchangers / physiology; Tight Junctions / metabolism; Tight Junctions / ultrastructure
TL;DR: Recovery of barrier function was assessed in wild-type (NHE2(+/+)) and NHE2(-/-) mice in vivo and in vitro and pharmacological inhibition of N HE2 in postischemic tissues from wild- type mice also resulted in significant reductions in TER. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs

American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2), G413–G421.

By: A. Moeser n, K. Ryan n, P. Nighot* & A. Blikslager n 

Contributors: A. Moeser n, K. Ryan n, P. Nighot* & A. Blikslager n 

author keywords: stress; barrier function; corticotropin releasing factor; tryptase
MeSH headings : Aging / metabolism; Animals; Cell Degranulation / drug effects; Colon, Ascending / drug effects; Colon, Ascending / metabolism; Corticotropin-Releasing Hormone / blood; Cromolyn Sodium / pharmacology; Cromolyn Sodium / therapeutic use; Electric Impedance; Gastrointestinal Agents / pharmacology; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / enzymology; Gastrointestinal Diseases / metabolism; Gastrointestinal Diseases / prevention & control; Gastrointestinal Diseases / psychology; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Secretions / metabolism; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / enzymology; Mast Cells / metabolism; Permeability; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / complications; Stress, Psychological / enzymology; Stress, Psychological / metabolism; Swine; Time Factors; Tryptases / metabolism; Up-Regulation; Weaning
TL;DR: The results indicate that early-weaning stress induces mucosal dysfunction mediated by intestinal mast cell activation and can be prevented by delaying weaning. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine

American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.

By: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

Contributors: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
TL;DR: Selective inhibition of NHE2, and not NHE3, induces recovery of barrier function in the ischemia-injured intestine. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.

By: A. Moeser n, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

Contributors: A. Moeser n, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
TL;DR: The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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