Keith Gagnon

Works (7)

Updated: July 5th, 2023 15:54

2012 article

Structurally Conserved Nop56/58 N-terminal Domain Facilitates Archaeal Box C/D Ribonucleoprotein-guided Methyltransferase Activity

Gagnon, K. T., Biswas, S., Zhang, X., Brown, B. A., Wollenzien, P., Mattos, C., & Maxwell, E. S. (2012, April 12). Journal of Biological Chemistry.

By: K. Gagnon n, S. Biswas n, X. Zhang n, B. Brown n, P. Wollenzien n, C. Mattos n, E. Maxwell n

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / genetics; Chromosomal Proteins, Non-Histone / metabolism; Methanococcales / chemistry; Methanococcales / genetics; Methanococcales / metabolism; Methyltransferases / chemistry; Methyltransferases / genetics; Methyltransferases / metabolism; Protein Binding; Protein Structure, Tertiary; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Cancer-related gene regulation
TL;DR: The archaeal Nop56/58 NTD exhibits a conserved domain structure whose exceptionally stable interaction with fibrillarin plays a role in both RNP assembly and methyltransferase activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins

Bleichert, F., Gagnon, K. T., Brown, B. A., Maxwell, E. S., Leschziner, A. E., Unger, V. M., & Baserga, S. J. (2009, September 10). Science.

By: F. Bleichert *, K. Gagnon n, B. Brown n, E. Maxwell n, A. Leschziner *, V. Unger*, S. Baserga *

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / metabolism; Archaeal Proteins / ultrastructure; Base Sequence; Chromosomal Proteins, Non-Histone / chemistry; Methanococcales / chemistry; Microscopy, Electron; Models, Molecular; Molecular Weight; Nucleic Acid Conformation; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; RNA, Archaeal / chemistry; RNA, Archaeal / ultrastructure; Ribonucleoproteins / chemistry; Ribonucleoproteins / metabolism; Ribonucleoproteins / ultrastructure
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: The structure of a reconstituted and catalytically active box C/D sRNP from the archaeon Methanocaldococcus jannaschii was determined by single-particle electron microscopy and Mutational analysis demonstrated that this di-sRNP structure was relevant for the enzymatic function of archaeal box C /D sRNPs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

A role for hydrophobicity in a Diels–Alder reaction catalyzed by pyridyl-modified RNA

Gagnon, K. T., Ju, S.-Y., Goshe, M. B., Maxwell, E. S., & Franzen, S. (2009, March 20). Nucleic Acids Research, Vol. 37, pp. 3074–3082.

By: K. Gagnon n, S. Ju n, M. Goshe n, E. Maxwell n & S. Franzen n 

MeSH headings : Anthracenes / metabolism; Base Sequence; Catalysis; Ethylene Glycols / metabolism; Hydrophobic and Hydrophilic Interactions; Lactones; Molecular Sequence Data; Nucleic Acid Conformation; Pyridines / chemistry; RNA / chemistry; RNA / metabolism; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Sesquiterpenes
topics (OpenAlex): RNA and protein synthesis mechanisms; DNA and Nucleic Acid Chemistry; Bacterial Genetics and Biotechnology
TL;DR: It is shown that DA_TR96, the most active member of the DA22 RNA sequence family, which was selected with pyridyl-modified nucleotides, accelerates a cycloaddition reaction between anthracene and maleimide derivatives with high turnover, and suggests a key role for the hydrophobic effect in the catalytic mechanism. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif

Gagnon, K. T., Zhang, X., Qu, G., Biswas, S., Suryadi, J., Brown, B. A., & Maxwell, E. S. (2009, November 19). RNA.

By: K. Gagnon n, X. Zhang n, G. Qu n, S. Biswas n, J. Suryadi *, B. Brown n, E. Maxwell n

author keywords: box C/D snoRNA; snoRNP; kink-turn; L7Ae/L30 proteins; RNA-protein interaction
MeSH headings : Amino Acid Motifs / physiology; Amino Acid Sequence; Archaea / genetics; Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Base Sequence; Binding Sites / genetics; Conserved Sequence; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Protein Binding / genetics; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Sequence Homology, Amino Acid
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: These five signature amino acids are distinct for each of the L7Ae/L30 family members, suggesting an evolutionary continuum of these RNA-binding proteins for recognition of the various K-turn motifs contained in their cognate RNAs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

In Vitro Reconstitution and Affinity Purification of Catalytically Active Archaeal Box C/D sRNP Complexes

Gagnon, K., Zhang, X., & Maxwell, E. S. (2007, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology.

By: K. Gagnon n, X. Zhang n & E. Maxwell n

MeSH headings : Chromatography, Affinity / methods; Chromatography, Ion Exchange / methods; Methanococcaceae; Ribonucleoproteins, Small Nuclear / isolation & purification
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Bacterial Genetics and Biotechnology
TL;DR: A novel affinity purification scheme that uses differentially tagged core proteins and a sequential three-step affinity selection protocol that yields fully assembled and catalytically active box C/D RNPs. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2007 article

The TRIUMF nuclear structure program and TIGRESS

Garrett, P. E., Andreyev, A., Austin, R. A. E., Ball, G. C., Bandyopadhyay, D., Becker, J. A., … Zganjar, E. F. (2007, May 2). Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms.

By: P. Garrett *, A. Andreyev *, R. Austin*, G. Ball *, D. Bandyopadhyay *, J. Becker*, A. Boston*, H. Boston* ...

author keywords: nuclear structure; radioactive decay; gamma-ray spectrometers; conversion electron spectrometer; radioactive ion beams
topics (OpenAlex): Nuclear physics research studies; Nuclear Physics and Applications; Nuclear reactor physics and engineering
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Source: Web Of Science
Added: August 6, 2018

2006 article

Assembly of the Archaeal Box C/D sRNP Can Occur via Alternative Pathways and Requires Temperature-facilitated sRNA Remodeling

Gagnon, K. T., Zhang, X., Agris, P. F., & Maxwell, E. S. (2006, August 7). Journal of Molecular Biology.

By: K. Gagnon n, X. Zhang n, P. Agris n & E. Maxwell n

MeSH headings : Amino Acid Sequence; Archaea / chemistry; Archaea / genetics; Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; Base Sequence; Chromatography, Affinity; Circular Dichroism; Methylation; Models, Biological; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Binding; RNA, Archaeal / chemistry; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / metabolism; RNA, Small Nucleolar / chemistry; RNA, Small Nucleolar / genetics; RNA, Small Nucleolar / metabolism; Ribonucleoproteins, Small Nuclear / chemistry; Ribonucleoproteins, Small Nuclear / genetics; Ribonucleoproteins, Small Nuclear / metabolism; Temperature
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Parasitic Infections and Diagnostics
TL;DR: RNA remodeling appears to be a common and requisite feature of archaeal dual-guide box C/D sR NP assembly and formation of the mature sRNP can follow different assembly pathways in generating catalytically active complexes. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

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