Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix
Newman, D. R., Walsh, E., Apparao, K. B. C., & Sannes, P. L. (2007, September 1). American Journal of Physiology-Lung Cellular and Molecular Physiology.
author keywords: coculture; alveolus; sulfation
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cells, Cultured; Extracellular Matrix / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Heparin / pharmacology; Intercellular Signaling Peptides and Proteins; Lung / cytology; Lung / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sulfotransferases / genetics; Sulfotransferases / metabolism
topics (OpenAlex): Proteoglycans and glycosaminoglycans research; Fibroblast Growth Factor Research; Neonatal Respiratory Health Research
TL;DR:
Results demonstrate a potentially important modulatory influence of sulfated ECMs and fibroblasts on FGF-BP and NDST-1 at the gene expression level and demonstrate that performed ECM appears to supply factors that modify subsequent treatment effects.
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