Works (4)
Updated: July 5th, 2023 15:55
2008 journal article
Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles
TOXICOLOGY IN VITRO, 22(2), 491–497.
Contributors: n, C. Haslauer n, E. Loboa n & N. Monteiro-Riviere n
author keywords: quantum dot nanoparticles; keratinocytes; skin; tensile strain; cellular uptake
MeSH headings : Borates / toxicity; Cell Membrane Permeability / drug effects; Cell Survival / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Epidermal Cells; Epidermis / drug effects; Ethidium; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Keratinocytes / physiology; Microscopy, Fluorescence; Pharmaceutical Vehicles / chemistry; Polyethylene Glycols / chemistry; Quantum Dots; Tensile Strength
TL;DR:
Application of physiological load conditions can increase cell membrane permeability, thereby increasing the concentration of QD nanoparticles in cells, and addition of strain results in an increase in cytokine production and QD uptake, resulting in irritation and a negative impact on cell viability.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
A linear dilution microfluidic device for cytotoxicity assays
LAB ON A CHIP, 7(2), 226–232.
Contributors: G. Walker n, N. Monteiro-Riviere n , n & . Adrian T. O'Neill n
MeSH headings : Cells, Cultured; Combinatorial Chemistry Techniques; Diffusion; Drug Evaluation, Preclinical / instrumentation; Drug Evaluation, Preclinical / methods; Electrochemistry / methods; Equipment Design; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microchemistry; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Microfluidics; Models, Statistical; Models, Theoretical
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin
NANO LETTERS, 7(1), 155–160.
Contributors: n, J. Yang n, J. Ryman-Rasmussen n, A. Barron n & N. Monteiro-Riviere n
MeSH headings : Amino Acids / chemistry; Fluorescein-5-isothiocyanate; Fullerenes / chemistry; Microscopy, Confocal; Nanoparticles / chemistry; Nuclear Localization Signals; Peptides / pharmacokinetics; Skin Absorption
TL;DR:
TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes
TOXICOLOGY IN VITRO, 20(8), 1313–1320.
Contributors: n, J. Yang *, A. Barron * & N. Monteiro-Riviere n
author keywords: fullerene; cytotoxicity; human epidermal keratinocytes; nanoparticles
MeSH headings : Amino Acids / toxicity; Cell Line; Cell Survival / drug effects; Cytokines / analysis; Cytokines / biosynthesis; Cytokines / metabolism; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Tetrazolium Salts; Thiazoles; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR:
Results indicate that concentrations lower than 0.04 mg/mL initiate less cytokine activity and maintain cell viability in HEK, and decrease cell viability and initiate a pro-inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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