@article{hodgson_wallace_shah_choi_joo_2014, title={Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations}, volume={28}, ISSN={["1099-0461"]}, DOI={10.1002/jbt.21534}, abstractNote={ABSTRACT}, number={1}, journal={JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}, author={Hodgson, Ernest and Wallace, Andrew D. and Shah, Ruchir R. and Choi, Kyoungju and Joo, Hyun}, year={2014}, month={Jan}, pages={1–10} } @article{choi_cope_harms_law_2012, title={Rapid decreases in salinity, but not increases, lead to immune dysregulation in Nile tilapia,Oreochromis niloticus(L.)}, volume={36}, ISSN={0140-7775}, url={http://dx.doi.org/10.1111/j.1365-2761.2012.01417.x}, DOI={10.1111/j.1365-2761.2012.01417.x}, abstractNote={Abstract}, number={4}, journal={Journal of Fish Diseases}, publisher={Wiley}, author={Choi, K and Cope, W G and Harms, C A and Law, J M}, year={2012}, month={Nov}, pages={389–399} } @article{joo_choi_hodgson_2010, title={Human metabolism of atrazine}, volume={98}, ISSN={["1095-9939"]}, DOI={10.1016/j.pestbp.2010.05.002}, abstractNote={Atrazine (ATZ) metabolism by human liver microsomes (HLM), cytochrome P450 (CYP) isoforms, and human liver (HL) S9 fractions, was investigated using HPLC/PDA and LC/MS/MS. CYP-dependent metabolites from pooled HLM are desethylatrazine (DEA), desisopropylatrazine (DIA), 1-hydroxyisopropylatrazine (HIATZ), and 2-hydroxyethyl atrazine (HEATZ). DEA and DIA were major metabolites in pooled HLM. CYP1A2 and 2C19, respectively, were major isoforms for DEA and DIA production. CYP3A4, while less active, is generally at high concentrations, produces both DEA and DIA and is significant. The percent total normalized rates (%TNR) for CYP1A2 and 3A4 in pooled HLM were 63% and 24% for DEA, and 35% and 56% for DIA production. Single donor HLM samples, showed correlations for CYP1A2 (r = 0.92) and 3A4 (r = 0.81) for DEA and DIA production, while variations in production of DEA and DIA were 8.5- and 6.0-fold, respectively. Pooled S9 fractions also mediate glutathione conjugation of atrazine, DEA and DIA.}, number={1}, journal={PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY}, author={Joo, Hyun and Choi, Kyoungju and Hodgson, Ernest}, year={2010}, month={Sep}, pages={73–79} } @article{choi_lehmann_harms_law_2007, title={Acute hypoxia-reperfusion triggers immunocompromise in Nile tilapia}, volume={19}, ISSN={["1548-8667"]}, DOI={10.1577/H06-010.1}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF AQUATIC ANIMAL HEALTH}, author={Choi, K. and Lehmann, D. W. and Harms, C. A. and Law, J. M.}, year={2007}, month={Jun}, pages={128–140} } @article{joo_choi_rose_hodgson_2007, title={Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos}, volume={21}, ISSN={["1095-6670"]}, DOI={10.1002/jbt.20161}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}, author={Joo, Hyun and Choi, Kyoungju and Rose, Randy L. and Hodgson, Ernest}, year={2007}, pages={76–80} } @article{choi_joo_rose_hodgson_2006, title={Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes}, volume={20}, DOI={10.1002/jbt.20145}, abstractNote={Abstract}, number={6}, journal={Journal of Biochemical and Molecular Toxicology}, author={Choi, K. and Joo, H. and Rose, R. L. and Hodgson, E.}, year={2006}, pages={279–291} }