Parikshit Chandra Das

Works (4)

Updated: July 5th, 2023 15:55

2010 journal article

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Toxicology and Applied Pharmacology, 245(3), 335–343.

By: R. Casabar, P. Das, G. DeKrey, C. Gardiner, Y. Cao, R. Rose, A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna

PLoS ONE, 5(8), e12453.

By: B. Hannas n, P. Das n, H. Li n & G. LeBlanc n 

Ed(s): X. Pan

MeSH headings : Animals; Animals, Newborn; Daphnia / cytology; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Drosophila / cytology; Drosophila / drug effects; Drosophila / metabolism; Ecdysteroids / metabolism; Ecosystem; Endocrine System / drug effects; Endocrine System / metabolism; Environmental Monitoring; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Female; Intracellular Space / drug effects; Intracellular Space / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitric Oxide / metabolism; Nitrites / metabolism; Nitrites / toxicity; Reproduction / drug effects; Risk
TL;DR: Results demonstrate that nitrite elicits developmental and reproductive toxicity at environmentally relevant concentrations due likely to its intracellular conversion to nitric oxide. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 review

Atrazine and reproductive function: Mode and mechanism of action studies

[Review of ]. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 80(2), 98–112.

By: R. Cooper, S. Laws, P. Das, M. Narotsky, J. Goldman, E. Tyrey, T. Stoker

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes

Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, December 15). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 164, pp. 200–214.

By: P. Das n, Y. Cao n, N. Cherrington *, E. Hodgson n & R. Rose n

author keywords: fipronil; human hepatic and HepG2 cells; CYP3A4; CYP2B6; CYP1A1; cytotoxicity; apoptosis
MeSH headings : Caspase 3 / metabolism; Caspase 7 / metabolism; Cell Survival / drug effects; Cells, Cultured; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Gene Expression Regulation; Hepatocytes / drug effects; Hepatocytes / enzymology; Humans; Isoenzymes / genetics; Isoenzymes / metabolism; Pyrazoles / chemistry; Pyrazoles / pharmacology; RNA, Messenger / genetics; Sulfur / chemistry; Transcription, Genetic / genetics; fas Receptor / metabolism
TL;DR: The results indicate both that HepG2 cells and primary human hepatocytes are sensitive to the cytotoxic effects of fipronil and caspase-3/7 in concurrence with compromised ATP production and viability are attributed to apoptotic cell death. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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