@article{prugnolle_mcgee_keebler_awadalla_2008, title={Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents}, volume={8}, journal={BMC Evolutionary Biology}, author={Prugnolle, F. and Mcgee, K. and Keebler, J. and Awadalla, P.}, year={2008} }
 @article{mu_awadalla_duan_mcgee_keebler_seydel_mcvean_su_2007, title={Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome}, volume={39}, ISSN={["1546-1718"]}, DOI={10.1038/ng1924}, abstractNote={One goal in sequencing the Plasmodium falciparum genome, the agent of the most lethal form of malaria, is to discover vaccine and drug targets. However, identifying those targets in a genome in which approximately 60% of genes have unknown functions is an enormous challenge. Because the majority of known malaria antigens and drug-resistant genes are highly polymorphic and under various selective pressures, genome-wide analysis for signatures of selection may lead to discovery of new vaccine and drug candidates. Here we surveyed 3,539 P. falciparum genes ( approximately 65% of the predicted genes) for polymorphisms and identified various highly polymorphic loci and genes, some of which encode new antigens that we confirmed using human immune sera. Our collections of genome-wide SNPs ( approximately 65% nonsynonymous) and polymorphic microsatellites and indels provide a high-resolution map (one marker per approximately 4 kb) for mapping parasite traits and studying parasite populations. In addition, we report new antigens, providing urgently needed vaccine candidates for disease control.}, number={1}, journal={NATURE GENETICS}, author={Mu, Jianbing and Awadalla, Philip and Duan, Junhui and McGee, Kate M. and Keebler, Jon and Seydel, Karl and McVean, Gilean A. T. and Su, Xin-zhuan}, year={2007}, month={Jan}, pages={126–130} }