Ruwan Deepal Sumanasinghe

Works (8)

Updated: July 28th, 2023 21:16

2010 journal article

Melt Spun Microporous Fibers Using Poly(lactic acid) and Sulfonated Copolyester Blends for Tissue Engineering Applications

JOURNAL OF APPLIED POLYMER SCIENCE, 117(6), 3350–3361.

By: R. Sumanasinghe n, C. Haslauer *, B. Pourdeyhimi n  & E. Loboa *

author keywords: biomaterials; blends; fibers; water soluble polymers
TL;DR: Results show that SP can be successfully used in a blend with PLA to produce microporous fibers to fabricate three-dimensional nonwoven scaffolds for tissue engineering applications. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Modulation of collagen gel compaction by extracellular ATP is MAPK and NF-kappa B pathways dependent

EXPERIMENTAL CELL RESEARCH, 315(11), 1990–2000.

By: J. Qi n, L. Chi *, J. Wang *, R. Sumanasinghe*, M. Wall*, M. Tsuzaki*, A. Banes n

author keywords: ATP; Collagen gel; P2 receptor; bone; NF-kappa B; MAPK; Prestress
MeSH headings : 3T3 Cells; Adenosine Triphosphate / metabolism; Adenosine Triphosphate / pharmacology; Adenylyl Cyclases / metabolism; Animals; Base Sequence; Calmodulin / metabolism; Collagen / genetics; Collagen / metabolism; DNA Primers / genetics; Extracellular Fluid / metabolism; Gels; Gene Expression / drug effects; Kinetics; MAP Kinase Signaling System; Mechanotransduction, Cellular; Mice; Models, Biological; Myosin-Light-Chain Kinase / metabolism; NF-kappa B / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Receptors, Purinergic P2 / metabolism; Stress, Mechanical
TL;DR: The results from the present and previous studies indicate that extracellular ATP may act as a negative feedback modulator in the mechanotransduction system since mechanical stimuli increase ATP release from stimulated cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain

JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.

By: R. Sumanasinghe*, T. Pfeiler*, N. Monteiro-Riviere n  & E. Loboa*

Contributors: R. Sumanasinghe*, T. Pfeiler*, N. Monteiro-Riviere n  & E. Loboa*

MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
TL;DR: IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain

JOURNAL OF BIOMECHANICS, 41(10), 2289–2296.

By: T. Pfeiler n, R. Sumanasinghe n & E. Loboa n

author keywords: uniaxial tensile strain; HMSCs; collagen; bioreactor; finite element modeling
MeSH headings : Biomechanical Phenomena / methods; Bioreactors; Cell Lineage; Cells, Cultured; Collagen / chemistry; Cytoskeleton / metabolism; Finite Element Analysis; Humans; Mesenchymal Stem Cells / cytology; Models, Theoretical; Pressure; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
TL;DR: Finite element models were created to evaluate the local loading conditions on bone marrow-derived hMSCs seeded in three-dimensional collagen matrices exposed to cyclic tensile strain and it was determined that globally applied uniaxial tensile strains of 10% and 12% resulted in local strains up to 18.3% and 21.8%, respectively. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Mesenchymal stem cell-seeded collagen matrices for bone repair: Effects of cyclic tensile strain, cell density, and media conditions on matrix contraction in vitro

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 88A(3), 778–786.

By: R. Sumanasinghe n, J. Osborne n & E. Loboa*

author keywords: bone tissue engineering; mechanical stimulation; osteogenic differentiation; collagen contraction; mesenchymal stem cells
MeSH headings : Adult; Bone and Bones / cytology; Cell Culture Techniques / methods; Cell Differentiation; Cell Survival; Collagen; Culture Media, Conditioned; Humans; Male; Mesenchymal Stem Cells / cytology; Tensile Strength
TL;DR: Findings suggest a correlation between hMSC proliferation and osteogenic differentiation on collagen matrix contraction that is affected by media, cell-seeding density, and cyclic tensile strain. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: Effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression

Sumanasinghe, R. D., Bernacki, S. H., & Loboa, E. G. (2006, December). TISSUE ENGINEERING, Vol. 12, pp. 3459–3465.

By: R. Sumanasinghe n, S. Bernacki n & E. Loboa n

MeSH headings : Adult; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins / biosynthesis; Bone Morphogenetic Proteins / genetics; Bone and Bones / cytology; Bone and Bones / metabolism; Cell Differentiation / physiology; Cell Survival / physiology; Cells, Cultured; Collagen Type I; Gene Expression Regulation, Developmental / physiology; Humans; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; RNA, Messenger / biosynthesis; Tensile Strength; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / genetics
TL;DR: This is the first report of the culture of bone marrow-derived hMSCs in 3D collagen matrices under cyclic strain, and the first demonstration that strain alone can induce osteogenic differentiation without the addition of osteogenic supplements. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

The application of biotextiles in tissue engineering

Research Journal of Textile & Apparel, 9, 80–90.

By: M. King  & R. Sumanasinghe

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

New trends in Biotextiles: The challenge of tissue engineering

Journal of Textile and Apparel Technology and Management, 3(2), 1–13.

By: R. Sumanasinghe & M. King 

Source: NC State University Libraries
Added: August 6, 2018

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