@article{sumanasinghe_haslauer_pourdeyhimi_loboa_2010, title={Melt Spun Microporous Fibers Using Poly(lactic acid) and Sulfonated Copolyester Blends for Tissue Engineering Applications}, volume={117}, ISSN={["1097-4628"]}, DOI={10.1002/app.32025}, abstractNote={Abstract}, number={6}, journal={JOURNAL OF APPLIED POLYMER SCIENCE}, author={Sumanasinghe, Ruwan D. and Haslauer, Carla M. and Pourdeyhimi, Behnam and Loboa, Elizabeth G.}, year={2010}, month={Sep}, pages={3350–3361} }
 @article{sumanasinghe_pfeiler_monteiro-riviere_loboa_2009, title={Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain}, volume={219}, ISSN={["1097-4652"]}, url={http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000263572000009&KeyUID=WOS:000263572000009}, DOI={10.1002/jcp.21653}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF CELLULAR PHYSIOLOGY}, author={Sumanasinghe, Ruwan D. and Pfeiler, T. Wayne and Monteiro-Riviere, Nancy A. and Loboa, Elizabeth G.}, year={2009}, month={Apr}, pages={77–83} }
 @article{sumanasinghe_osborne_loboa_2009, title={Mesenchymal stem cell-seeded collagen matrices for bone repair: Effects of cyclic tensile strain, cell density, and media conditions on matrix contraction in vitro}, volume={88A}, ISSN={["1552-4965"]}, DOI={10.1002/jbm.a.31913}, abstractNote={Abstract}, number={3}, journal={JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A}, author={Sumanasinghe, Ruwan D. and Osborne, Jason A. and Loboa, Elizabeth G.}, year={2009}, month={Mar}, pages={778–786} }
 @article{qi_chi_wang_sumanasinghe_wall_tsuzaki_banes_2009, title={Modulation of collagen gel compaction by extracellular ATP is MAPK and NF-kappa B pathways dependent}, volume={315}, ISSN={["0014-4827"]}, DOI={10.1016/j.yexcr.2009.02.012}, abstractNote={Understanding the mechanisms that regulate mechanosensitivity in osteoblasts is important for controlling bone homeostasis and the development of new drugs to combat bone loss. It is believed that prestress or force generation (the tensile stress within the cell body) plays an important role in regulating cellular mechanosensitivity. In the present study, a three-dimensional (3D) collagen culture was used to monitor the change in prestress of the osteoblast-like cells. Collagen hydrogel compaction has been used as an indicator of the change in the degree of cell prestress. Previous results in this model demonstrated that extracellular ATP reduced the mechanosensitivity of osteoblasts by reducing cellular prestress. To elucidate the potential mechanisms involved in this process, the signaling pathways downstream of P2 purinoceptors involved in regulating the compaction of type I collagen gels were investigated. By using specific inhibitors to these signaling pathways, we found that ATP-induced reduction in collagen gel compaction rate is dependent on mitogen-activated protein kinase (MAKP) and NF-κB pathways. However, blocking protein kinase C with GF109203X did not change the compaction kinetics in the presence of ATPγS. Moreover, blocking cyclic AMP (cAMP), phosphatidylinositol-3 kinase (PI3K), calmodulin (CaM) or L-type voltage sensitive calcium channels did not affect ATP's ability to reduce collagen gel compaction. The results from the present and previous studies indicate that extracellular ATP may act as a negative feedback modulator in the mechanotransduction system since mechanical stimuli increase ATP release from stimulated cells.}, number={11}, journal={EXPERIMENTAL CELL RESEARCH}, author={Qi, Jie and Chi, Liqun and Wang, Jian and Sumanasinghe, Ruwan and Wall, Michelle and Tsuzaki, Mari and Banes, Albert J.}, year={2009}, month={Jul}, pages={1990–2000} }
 @article{pfeiler_sumanasinghe_loboa_2008, title={Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain}, volume={41}, ISSN={["1873-2380"]}, DOI={10.1016/j.jbiomech.2008.04.007}, abstractNote={The use of human mesenchymal stem cells (hMSCs) in tissue engineering is attractive due to their ability to extensively self-replicate and differentiate into a multitude of cell lineages. It has been experimentally established that hMSCs are influenced by chemical and mechanical signals. However, the combined chemical and mechanical in vitro culture conditions that lead to functional tissue require greater understanding. In this study, finite element models were created to evaluate the local loading conditions on bone marrow-derived hMSCs seeded in three-dimensional collagen matrices exposed to cyclic tensile strain. Mechanical property and geometry data used in the models were obtained experimentally from a previous study in our laboratory and from mechanical testing. Eight finite element models were created to simulate three-dimensional hMSC-seeded collagen matrices exposed to different levels of cyclic tensile strain (10% and 12%), culture media (complete growth and osteogenic differentiating), and durations of culture (7 and 14 days). Through finite element analysis, it was determined that globally applied uniaxial tensile strains of 10% and 12% resulted in local strains up to 18.3% and 21.8%, respectively. Model results were also compared to experimental studies in an attempt to explain observed differences between hMSC response to 10% and 12% cyclic tensile strain.}, number={10}, journal={JOURNAL OF BIOMECHANICS}, author={Pfeiler, T. Wayne and Sumanasinghe, Ruwan D. and Loboa, Elizabeth G.}, year={2008}, month={Jul}, pages={2289–2296} }
 @article{sumanasinghe_bernacki_loboa_2006, title={Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: Effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression}, volume={12}, ISSN={["1076-3279"]}, DOI={10.1089/ten.2006.12.3459}, abstractNote={Human mesenchymal stem cells (hMSCs) differentiate down an osteogenic pathway with appropriate mechanical and/or chemical stimuli. This study describes the successful culture of hMSCs in 3D collagen matrices under mechanical strain. Bone marrow-derived hMSCs were seeded in linear 3D type I collagen matrices and subjected to 0%, 10%, or 12% uniaxial cyclic tensile strain at 1 Hz for 4 h/day for 7 or 14 days. Cell viability studies indicated that hMSCs remained viable throughout the culture period irrespective of the applied strain level. Real-time RT-PCR studies indicated a significant increase in BMP-2 mRNA expression levels in hMSCs strained at 10% compared to the same day unstrained controls after both 7 and 14 days. An increase in BMP-2 was also observed in hMSCs subjected to 12% strain, but the increase was significant only in the 14-day sample. This is the first report of the culture of bone marrow-derived hMSCs in 3D collagen matrices under cyclic strain, and the first demonstration that strain alone can induce osteogenic differentiation without the addition of osteogenic supplements. Induction of bone differentiation in 3D culture is a critical step in the creation of bioengineered bone constructs.}, number={12}, journal={TISSUE ENGINEERING}, author={Sumanasinghe, Ruwan D. and Bernacki, Susan H. and Loboa, Elizabeth G.}, year={2006}, month={Dec}, pages={3459–3465} }
 @article{king_sumanasinghe_2005, title={The application of biotextiles in tissue engineering}, volume={9}, journal={Research Journal of Textile & Apparel}, author={King, M. W. and Sumanasinghe, R.}, year={2005}, pages={80–90} }
 @article{sumanasinghe_king_2003, title={New trends in Biotextiles: The challenge of tissue engineering}, volume={3}, number={2}, journal={Journal of Textile and Apparel Technology and Management}, author={Sumanasinghe, R. D. and King, M. W.}, year={2003}, pages={1–13} }