Vanessa L. Cook

Works (8)

Updated: July 8th, 2023 21:16

2010 journal article

Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs

American Journal of Veterinary Research, 71(6), 630–635.

By: J. Wooten n, B. Lascelles  n, V. Cook n, J. Law n & A. Blikslager n 

Contributors: J. Wooten n, B. Lascelles  n, V. Cook n, J. Law n & A. Blikslager n 

MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR: Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses

American Journal of Veterinary Research, 70(10), 1259–1268.

By: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n 

Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR: In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum

American Journal of Veterinary Research, 70(8), 992–1000.

By: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n 

Contributors: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n 

MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Blotting, Western / veterinary; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Eicosanoids / blood; Electrophoresis, Polyacrylamide Gel / veterinary; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Jejunal Diseases / drug therapy; Jejunal Diseases / veterinary; Sulfones / therapeutic use; Thromboxane B2 / blood
TL;DR: Firocoxib may be advantageous in horses recovering from ischemic intestinal injury, while providing effective analgesia in horses treated with flunixin meglumine and firo Coxib. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

The effect of lidocaine on in vitro adhesion and migration of equine neutrophils

Veterinary Immunology and Immunopathology, 129(1-2), 137–142.

By: V. Cook n, L. Neuder n, A. Blikslager n  & S. Jones n 

Contributors: V. Cook n, L. Neuder n, A. Blikslager n  & S. Jones n 

author keywords: Neutrophils; Equine; Immune functions; Local anesthetics
MeSH headings : Anesthetics, Local / pharmacology; Animals; Cell Adhesion / drug effects; Cell Adhesion / immunology; Cell Movement / drug effects; Cell Movement / immunology; Horses / blood; Horses / immunology; Interleukin-8 / immunology; Leukotriene B4 / immunology; Lidocaine / pharmacology; Neutrophil Activation / drug effects; Neutrophil Activation / immunology; Neutrophils / drug effects; Neutrophils / immunology; Platelet Activating Factor / immunology
TL;DR: In conclusion, lidocaine did not inhibit neutrophil migration or adhesion in vitro at therapeutic concentrations, and increased migration and adhesion at higher concentrations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus

Equine Veterinary Journal, 42(1), 47–52.

By: M. Sheats* , V. Cook n, S. Jones n , A. Blikslager n  & A. Pease n

Contributors: M. Sheats* , V. Cook n, S. Jones n , A. Blikslager n  & A. Pease n

author keywords: horse; colic; large colon volvulus; ultrasound; multiple organ dysfunction syndrome; oedema
MeSH headings : Animals; Colic / diagnostic imaging; Colic / surgery; Colic / veterinary; Colonic Diseases / diagnostic imaging; Colonic Diseases / surgery; Colonic Diseases / veterinary; Female; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Male; Treatment Outcome; Ultrasonography
TL;DR: A shorter time to colon wall involution was associated with decreased post operative morbidity in horses presented for surgical correction of large colon volvulus without resection and may aid in identifying those cases at risk of MODS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2008 journal article

Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine

Equine Veterinary Journal, 40(4), 353–357.

By: V. Cook, J. Shults, M. McDowell, N. Campbell, J. Davis & A. Blikslager 

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Use of systemically administered lidocaine in horses with gastrointestinal tract disease

Journal of the American Veterinary Medical Association, 232(8), 1144–1148.

By: V. Cook* & A. Blikslager* 

Contributors: V. Cook* & A. Blikslager* 

MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / veterinary; Horse Diseases / drug therapy; Horses; Ileus / drug therapy; Ileus / veterinary; Lidocaine / therapeutic use; Reperfusion Injury / drug therapy; Reperfusion Injury / veterinary
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.

By: A. Moeser n, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

Contributors: A. Moeser n, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
TL;DR: The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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