Works (9)

Updated: July 22nd, 2023 21:14

2011 journal article

Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration

British Journal of Ophthalmology, 95(12), 1749–1754.

By: J. Sommer n, J. Estrada n, E. Collins n, M. Bedell*, C. Alexander n, Z. Yang*, G. Hughes*, B. Mir n ...

MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR: These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN

Transgenic Research, 19(5), 869–887.

By: A. McCalla-Martin n, X. Chen*, K. Linder n, J. Estrada n & J. Piedrahita n

author keywords: Basal cell carcinoma; Pig; Somatic cell nuclear transfer; Gli2; Hedgehog
MeSH headings : Animals; Animals, Genetically Modified / genetics; Animals, Suckling; Epidermis / metabolism; Epidermis / pathology; Female; Fibroblasts / metabolism; Genetic Predisposition to Disease; Hair Follicle / metabolism; Humans; Keratins / metabolism; Kruppel-Like Transcription Factors / genetics; Kruppel-Like Transcription Factors / physiology; Male; Mice; Nuclear Proteins / genetics; Nuclear Proteins / physiology; Phenotype; Pyoderma / etiology; Recombinant Fusion Proteins / physiology; Skin Diseases, Infectious / etiology; Skin Diseases, Infectious / pathology; Species Specificity; Sus scrofa; Swine / metabolism; Transgenes; Zinc Finger Protein Gli2
TL;DR: There is a need for a multiple species animal model approach in order to better understand the role of Gli2 in mammalian skin, as constitutive expression of the human hGli2ΔN in keratinocytes results in cutaneous changes that have not been reported in the K5-hGli-N murine model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

A comparative study on the efficiency of two enucleation methods in pig somatic cell nuclear transfer: Effects of the squeezing and the aspiration methods

ANIMAL BIOTECHNOLOGY, 19(2), 71–79.

By: E. Lee n, J. Estrada* & J. Piedrahita*

author keywords: enucleation; in vivo viability; pig; somatic cell nuclear transfer
MeSH headings : Animals; Animals, Newborn; Biotechnology / methods; Embryo Transfer / veterinary; Female; Litter Size; Nuclear Transfer Techniques / veterinary; Oocytes; Pregnancy; Swine
TL;DR: The results indicate that the aspiration method for oocyte enucleation is more efficient than the squeezing method in producing a large number of pig SCNT embryos with normal in vivo viability. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients

Estrada, J. L., Collins, B., York, A., Bischoff, S., Sommer, J., Tsai, S., … Piedrahita, J. A. (2008, June). CLONING AND STEM CELLS, Vol. 10, pp. 287–296.

By: J. Estrada n, B. Collins n, A. York n, S. Bischoff n, J. Sommer n, S. Tsai n, R. Petters n, J. Piedrahita n

MeSH headings : Animals; Cell Line; Cloning, Organism / methods; Fibroblasts / cytology; Microsatellite Repeats; Nuclear Transfer Techniques; Oocytes / physiology; Sus scrofa; Swine; Swine, Miniature / embryology
TL;DR: This report shows that it is possible to produce viable Yucatan SCNT clones and opens up the possibility of developing valuable biomedical models in this porcine breed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 review

Growth factors in the follicular development, embryonic early and implantation. Implications in the production of bovine embryos

[Review of ]. Revista MVZ Cordoba, 12(1), 942–954.

By: P. Miguel, G. Agustin & E. Jose

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR)

CLONING AND STEM CELLS, 9(2), 229–236.

By: J. Estrada n, J. Sommer n, B. Collins n, B. Mir n, A. Martin n, A. York n, R. Petters n, J. Piedrahita n

MeSH headings : Animals; Birth Weight / physiology; Fetal Growth Retardation; Insemination, Artificial; Litter Size / physiology; Nuclear Transfer Techniques; Swine
TL;DR: SCNT-derived pigs are excellent models to study epigenetic factors and genes involved in IUGRs, and to develop effective means to improve fetal growth in humans and animals, and there are some differences between SCNT- derived and AI litters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Synchronization and superovulation of mature cycling gilts for the collection of pronuclear stage embryos

ANIMAL REPRODUCTION SCIENCE, 100(3-4), 402–410.

By: J. Sommer n, E. Collins n, J. Estrada n & R. Petters n

author keywords: gilt; superovulation; estrous synchronization; pronuclear stage embryo; PG600 (R); prostaglandin F-2 alpha; transgenic
MeSH headings : Animals; Chorionic Gonadotropin / pharmacology; Dinoprost / analogs & derivatives; Dinoprost / pharmacology; Embryo, Mammalian; Estrous Cycle; Estrus Synchronization / methods; Female; Superovulation / drug effects; Superovulation / physiology; Swine / physiology
TL;DR: An efficient protocol to synchronize and superovulate mature pigs for the collection of pronuclear stage embryos suitable for DNA microinjection and Pigs 10-16 days after the beginning of standing estrus have been successfully synchronized into estrus using this protocol. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Detection of transcriptional difference of porcine imprinted genes using different microarray platforms

BMC Genomics, 7.

By: S. Tsai, B. Mir, A. Martin, J. Estrada, S. Bischoff, W. Hsieh, J. Cassady, B. Freking ...

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Effect of insulin-like growth factor-I on protein synthesis in porcine embryonic discs cultured in vitro

Journal of Reproduction & Fertility, 93(1), 53.

By: J. Estrada n, E. Jones, B. Johnson & R. Petters

MeSH headings : Animals; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Embryo, Mammalian / chemistry; Embryo, Mammalian / drug effects; Embryo, Mammalian / metabolism; Embryonic and Fetal Development / drug effects; Insulin-Like Growth Factor I / pharmacology; Molecular Weight; Protein Biosynthesis; Proteins / analysis; Swine / embryology; Swine / metabolism
TL;DR: Results show that IGF-I can stimulate protein synthesis in pig embryonic discs cultured in vitro and suggest that this growth factor may play an important role in regulating early development. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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