Works (5)
Updated: July 5th, 2023 15:55
2011 journal article
Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and Bone Development in Neonatal Pigs
JOURNAL OF NUTRITION, 141(3), 373–379.
Contributors: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung *, J. Odle n , n, E. Loboa n, C. Stahl n
MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism; Animals; Animals, Newborn; Bone Density; Bone Development; Bone and Bones / chemistry; Calcitriol / blood; Calcium / blood; Calcium / deficiency; Calcium, Dietary / administration & dosage; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Gene Expression Regulation; Male; Mechanical Phenomena; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Nutritional Status; Parathyroid Hormone / blood; RNA, Messenger / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Calcium-Sensing / metabolism; Sus scrofa
TL;DR:
The results indicate that neonatal Ca nutrition is crucial for bone integrity and suggest that early-life Ca restriction may have long-term effects on bone integrity via programming of MSC.
(via Semantic Scholar)
open access via jn.nutrition.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain
JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.
Contributors: R. Sumanasinghe*, T. Pfeiler*, N. Monteiro-Riviere n & E. Loboa*
MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
TL;DR:
IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain
JOURNAL OF BIOMECHANICS, 41(10), 2289–2296.
author keywords: uniaxial tensile strain; HMSCs; collagen; bioreactor; finite element modeling
MeSH headings : Biomechanical Phenomena / methods; Bioreactors; Cell Lineage; Cells, Cultured; Collagen / chemistry; Cytoskeleton / metabolism; Finite Element Analysis; Humans; Mesenchymal Stem Cells / cytology; Models, Theoretical; Pressure; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
TL;DR:
Finite element models were created to evaluate the local loading conditions on bone marrow-derived hMSCs seeded in three-dimensional collagen matrices exposed to cyclic tensile strain and it was determined that globally applied uniaxial tensile strains of 10% and 12% resulted in local strains up to 18.3% and 21.8%, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Genetic background influences fluoride's effects on osteoclastogenesis
BONE, 41(6), 1036–1044.
author keywords: F; osteoclastogenesis; hematopoietic colony-forming cell (CFC) assays; bone resorption markers; inbred mouse strains
MeSH headings : Alkaline Phosphatase / metabolism; Animals; Biomarkers / blood; Bone Density; Bone and Bones / cytology; Bone and Bones / metabolism; Colony-Forming Units Assay; Female; Fluorides / metabolism; Fluorides / pharmacology; Mice; Osteoclasts / drug effects; Osteoclasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Stress, Mechanical
TL;DR:
In conclusion, short term F treatment at physiological levels has strain-specific effects in mice and novel actions hallmarked by enhanced osteoclastogenesis shifts in hematopoietic cell differentiation in the C3H strain are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Semiautomated finite element mesh generation methods for a long bone
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 85(3), 196–202.
author keywords: canine radius; CT to FEA; four-point bending; strain gage
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Cadaver; Computer Simulation; Dogs; Finite Element Analysis; North Carolina; Tomography, X-Ray Computed
TL;DR:
A semi-automated finite element mesh generation method using computed tomography image data of a canine radius is developed and test to minimize user interaction and eliminate the need for mesh smoothing to produce a model suitable for finite element analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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