Terry Wayne Pfeiler

Works (5)

Updated: July 5th, 2023 15:55

2011 article

Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and Bone Development in Neonatal Pigs

Mahajan, A., Alexander, L. S., Seabolt, B. S., Catrambone, D. E., McClung, J. P., Odle, J., … Stahl, C. H. (2011, January 20). Journal of Nutrition, Vol. 141, pp. 373–379.

By: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung *, J. Odle n , T. Pfeiler n, E. Loboa n, C. Stahl n

Contributors: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung *, J. Odle n , T. Pfeiler n, E. Loboa n, C. Stahl n

MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism; Animals; Animals, Newborn; Bone Density; Bone Development; Bone and Bones / chemistry; Calcitriol / blood; Calcium / blood; Calcium / deficiency; Calcium, Dietary / administration & dosage; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Gene Expression Regulation; Male; Mechanical Phenomena; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Nutritional Status; Parathyroid Hormone / blood; RNA, Messenger / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Calcium-Sensing / metabolism; Sus scrofa
topics (OpenAlex): Birth, Development, and Health; Adipose Tissue and Metabolism; Nutrition and Health in Aging
TL;DR: The results indicate that neonatal Ca nutrition is crucial for bone integrity and suggest that early-life Ca restriction may have long-term effects on bone integrity via programming of MSC. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 article

Expression of proinflammatory cytokines by human mesenchymal stem cells in response to cyclic tensile strain

Sumanasinghe, R. D., Pfeiler, T. W., Monteiro‐Riviere, N. A., & Loboa, E. G. (2008, December 16). Journal of Cellular Physiology, Vol. 219, pp. 77–83.

By: R. Sumanasinghe*, T. Pfeiler n, N. Monteiro‐Riviere n  & E. Loboa n

Contributors: R. Sumanasinghe*, T. Pfeiler n, N. Monteiro-Riviere n  & E. Loboa n

MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
topics (OpenAlex): Mesenchymal stem cell research; Osteoarthritis Treatment and Mechanisms; Bone Tissue Engineering Materials
TL;DR: IL‐6 and IL‐8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL‐ 6 andIL‐8 may be functioning as autocrine signals during osteogenic differentiation of h MSCs. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 article

Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain

Pfeiler, T. W., Sumanasinghe, R. D., & Loboa, E. G. (2008, June 10). Journal of Biomechanics.

By: T. Pfeiler n, R. Sumanasinghe n & E. Loboa n

author keywords: uniaxial tensile strain; HMSCs; collagen; bioreactor; finite element modeling
MeSH headings : Biomechanical Phenomena / methods; Bioreactors; Cell Lineage; Cells, Cultured; Collagen / chemistry; Cytoskeleton / metabolism; Finite Element Analysis; Humans; Mesenchymal Stem Cells / cytology; Models, Theoretical; Pressure; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
topics (OpenAlex): Bone Tissue Engineering Materials; Collagen: Extraction and Characterization; Cellular and Composite Structures
TL;DR: Finite element models were created to evaluate the local loading conditions on bone marrow-derived hMSCs seeded in three-dimensional collagen matrices exposed to cyclic tensile strain and it was determined that globally applied uniaxial tensile strains of 10% and 12% resulted in local strains up to 18.3% and 21.8%, respectively. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Genetic background influences fluoride's effects on osteoclastogenesis

Yan, D., Gurumurthy, A., Wright, M., Pfeiler, T. W., Loboa, E. G., & Everett, E. T. (2007, August 9). Bone.

By: D. Yan *, A. Gurumurthy*, M. Wright n, T. Pfeiler n, E. Loboa n & E. Everett *

author keywords: F; osteoclastogenesis; hematopoietic colony-forming cell (CFC) assays; bone resorption markers; inbred mouse strains
MeSH headings : Alkaline Phosphatase / metabolism; Animals; Biomarkers / blood; Bone Density; Bone and Bones / cytology; Bone and Bones / metabolism; Colony-Forming Units Assay; Female; Fluorides / metabolism; Fluorides / pharmacology; Mice; Osteoclasts / drug effects; Osteoclasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Stress, Mechanical
topics (OpenAlex): Bone Metabolism and Diseases; Fluoride Effects and Removal; Bone and Dental Protein Studies
TL;DR: In conclusion, short term F treatment at physiological levels has strain-specific effects in mice and novel actions hallmarked by enhanced osteoclastogenesis shifts in hematopoietic cell differentiation in the C3H strain are demonstrated. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

Semiautomated finite element mesh generation methods for a long bone

Pfeiler, T. W., Lalush, D. S., & Loboa, E. G. (2007, January 5). Computer Methods and Programs in Biomedicine, Vol. 85, pp. 196–202.

By: T. Pfeiler n, D. Lalush n  & E. Loboa n

Contributors: T. Pfeiler n, D. Lalush n  & E. Loboa n

author keywords: canine radius; CT to FEA; four-point bending; strain gage
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Cadaver; Computer Simulation; Dogs; Finite Element Analysis; North Carolina; Tomography, X-Ray Computed
topics (OpenAlex): Bone fractures and treatments; Veterinary Orthopedics and Neurology; Bone health and osteoporosis research
TL;DR: A semi-automated finite element mesh generation method using computed tomography image data of a canine radius is developed and test to minimize user interaction and eliminate the need for mesh smoothing to produce a model suitable for finite element analysis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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