Sheila K. Jacobi

Works (18)

Updated: July 20th, 2023 21:18

2019 journal article

Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages

Journal of Animal Science and Biotechnology, 10(1).

By: K. Walter n, X. Lin n, S. Jacobi*, T. Käser  n, D. Esposito n  & J. Odle n 

Contributors: K. Walter n, X. Lin n, S. Jacobi*, T. Käser  n, D. Esposito n  & J. Odle n 

author keywords: Arachidonic acid; Cyclooxygenase; Eicosanoid; Eicosapentaenoic acid; Inflammation; Lipid mediator class switch; LPS; Lipoxin; Porcine alveolar macrophage
TL;DR: It is inferred that enriching diets with arachidonic acid may be an effective means to enhance a stronger innate immunologic response to respiratory challenges in neonatal pigs, but further work is needed to examine long-term safety, clinical efficacy and economic viability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 20, 2020

2016 journal article

Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets

JOURNAL OF NUTRITION, 146(2), 200–208.

By: S. Jacobi n, T. Yatsunenko*, D. Li*, S. Dasgupta*, R. Yu *, B. Berg*, M. Chichlowski *, J. Odle n 

Contributors: S. Jacobi n, T. Yatsunenko*, D. Li*, S. Dasgupta*, R. Yu *, B. Berg*, M. Chichlowski *, J. Odle n 

author keywords: oligosaccharides; infant formula; microbiome; intestine; brain; prebiotic
MeSH headings : Animals; Bacteria / growth & development; Brain / drug effects; Brain / metabolism; Cerebellum / drug effects; Cerebellum / metabolism; Colon / drug effects; Colon / microbiology; Corpus Callosum / drug effects; Corpus Callosum / metabolism; Diet; Dietary Supplements; Gangliosides / metabolism; Gastrointestinal Microbiome / drug effects; Infant Formula; Isomerism; Lactose / analogs & derivatives; Lactose / pharmacology; Milk, Human / chemistry; Oligosaccharides / pharmacology; Sialic Acids / pharmacology; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Transplacental induction of fatty acid oxidation in term fetal pigs by the peroxisome proliferator-activated receptor alpha agonist clofibrate

Journal of Animal Science and Biotechnology, 6(1).

By: X. Lin n, S. Jacobi n & J. Odle n 

Contributors: X. Lin n, S. Jacobi n & J. Odle n 

author keywords: Clofibrate; Fatty acid oxidation; Pigs; Placenta transfer
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

The Suckling Piglet as an Agrimedical Model for the Study of Pediatric Nutrition and Metabolism

Annual Review of Animal Biosciences, 2(1), 419–444.

By: J. Odle n , X. Lin n, S. Jacobi n, S. Kim n  & C. Stahl n

Contributors: J. Odle n , X. Lin n, S. Jacobi n, S. Kim n  & C. Stahl n

author keywords: agrimedical; milk; infant; fatty acid; oligosaccharide; amino acid; calcium; phosphorous
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Animals, Suckling; Child; Child Nutritional Physiological Phenomena; Humans; Swine / physiology
TL;DR: The broad scope of this review is to outline the fundamental elements of the piglet model and to highlight key aspects of relevance to various macronutrients, including lipids, carbohydrates, proteins/amino acids, and calcium/phosphorus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets

World Journal of Gastroenterology, 19(31), 5094–5102.

By: S. Jacobi n, A. Moeser, A. Blikslager , J. Rhoads, B. Corl, R. Harrell, J. Odle 

Contributors: S. Jacobi n, A. Moeser, A. Blikslager , J. Rhoads, B. Corl, R. Harrell, J. Odle 

author keywords: Rotavirus gastroenteritis; Kwashiorkor; Occludin; Ussing chamber; Villus
MeSH headings : Animals; Animals, Newborn; Diarrhea / metabolism; Diarrhea / virology; Disease Models, Animal; Electric Impedance; Humans; Infant Formula / metabolism; Infant, Newborn; Intestinal Absorption; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Mannitol / metabolism; Occludin / metabolism; Permeability; Protein-Energy Malnutrition / metabolism; Protein-Energy Malnutrition / pathology; Protein-Energy Malnutrition / virology; Rotavirus Infections / metabolism; Rotavirus Infections / pathology; Rotavirus Infections / virology; Swine; Tight Junctions / metabolism; Tight Junctions / virology; Time Factors; Weight Loss
TL;DR: Overall, malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Dietary supplementation of Bifidobacterium longum strain AH1206 increases its cecal abundance and elevates intestinal interleukin-10 expression in the neonatal piglet

Food and Chemical Toxicology, 60, 116–122.

By: T. Herfel n, S. Jacobi n, X. Lin n, Z. Jouni*, M. Chichlowski *, C. Stahl n, J. Odle n 

Contributors: T. Herfel n, S. Jacobi n, X. Lin n, Z. Jouni*, M. Chichlowski *, C. Stahl n, J. Odle n 

author keywords: Bifidobacteria; Probiotic; Infant; Intestinal health; Immune system; IL-10
MeSH headings : Animal Feed / microbiology; Animals; Animals, Newborn; Bifidobacterium; Cecum / microbiology; Colony Count, Microbial; Dietary Supplements; Immunoglobulin G / blood; Immunoglobulin M / blood; Interleukin-10 / genetics; Interleukin-10 / metabolism; Probiotics / administration & dosage; Swine; Weight Gain
TL;DR: Dietary supplementation with B. longum (AH1206) may be safe for human infants based on a lack of growth, development or deleterious immune-related effects observed in piglets, based on findings in the suckling piglet model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Stabilized rice bran improves weaning pig performance via a prebiotic mechanism

Journal of Animal Science, 91(2), 907–913.

By: T. Herfel n, S. Jacobi n, X. Lin n, E. Van Heugten  n, V. Fellner n  & J. Odle n 

Contributors: T. Herfel n, S. Jacobi n, X. Lin n, E. Heugten  n, V. Fellner n  & J. Odle n 

author keywords: antibiotics; gastrointestinal; microbiota; stabilized rice bran; swine
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Diet / veterinary; Intestines / anatomy & histology; Oryza / chemistry; Prebiotics; Swine / growth & development
TL;DR: SRB improved the efficiency of nutrient utilization in nursery diets lacking antibiotics and tended to increase intestinal bifidobacteria concentrations, indicating that SRB may exert beneficial prebiotic effects in weanling pigs. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Dietary Long-Chain PUFA Enhance Acute Repair of Ischemia-Injured Intestine of Suckling Pigs

The Journal of Nutrition, 142(7), 1266–1271.

By: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n  & J. Odle n 

Contributors: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n  & J. Odle n 

MeSH headings : Animals; Constriction; Diet; Dietary Fats / pharmacology; Dietary Supplements; Eicosapentaenoic Acid / pharmacology; Electric Impedance; Ileal Diseases / drug therapy; Ileal Diseases / pathology; Ileal Diseases / physiopathology; Ileum / drug effects; Ileum / pathology; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / blood; Ischemia / drug therapy; Ischemia / pathology; Ischemia / physiopathology; Mannitol / blood; Mesentery / blood supply; Swine; Wound Healing / drug effects
TL;DR: It is demonstrated that feeding elevated levels of long-chain PUFA enhances acute recovery of ischemia-injured porcine ileum, and a histological evaluation of ischemic ilea from piglets fed the 5% ARA showed reduced histological lesions after ischemIA compared with the other dietary groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of immunoglobulin G absorption from colostrum supplements gavaged to newborn piglets

JOURNAL OF ANIMAL SCIENCE, 90(SUPPL4), 299–301.

By: J. Campbell, S. Jacobi n, Y. Liu n, K. Robertson*, J. Drayton n, I. Medina n, J. Polo, J. Crenshaw, J. Odle n 

Contributors: J. Campbell, S. Jacobi n, Y. Liu n, K. Hard Robertson*, J. Drayton n, I. Medina n, J. Polo, J. Crenshaw, J. Odle n 

author keywords: colostrum; immnunoglobulin G; neonatal piglet; porcine plasma
MeSH headings : Absorption; Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Colostrum / chemistry; Dietary Supplements; Immunoglobulin G / administration & dosage; Immunoglobulin G / pharmacology; Swine / metabolism; Weight Loss
TL;DR: All colostrum supplements were comparable in delivering absorbable IgG to the neonatal piglet and the single dose yielded better piglet hydration as noted by less weight loss. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Fish Oil Enhances Intestinal Integrity and Inhibits TLR4 and NOD2 Signaling Pathways in Weaned Pigs after LPS Challenge

The Journal of Nutrition, 142(11), 2017–2024.

By: Y. Liu *, F. Chen *, J. Odle n , X. Lin n, S. Jacobi n, H. Zhu *, Z. Wu *, Y. Hou *

Contributors: Y. Liu *, F. Chen *, J. Odle n , X. Lin n, S. Jacobi n, H. Zhu *, Z. Wu *, Y. Hou *

MeSH headings : Animal Feed / analysis; Animals; Diet / veterinary; Docosahexaenoic Acids / chemistry; Docosahexaenoic Acids / metabolism; Eicosapentaenoic Acid / chemistry; Eicosapentaenoic Acid / metabolism; Fatty Acids, Omega-3 / genetics; Fatty Acids, Omega-3 / metabolism; Fish Oils / pharmacology; Gene Expression Regulation / drug effects; Intestinal Diseases / chemically induced; Intestinal Diseases / metabolism; Intestinal Mucosa; Intestines / drug effects; Lipopolysaccharides / toxicity; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Swine / metabolism; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism
TL;DR: Results indicate that fish oil supplementation is associated with inhibition of TLR4 and NOD2 signaling pathways and concomitant improvement of intestinal integrity under an inflammatory condition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 review

Nutritional Factors Influencing Intestinal Health of the Neonate

[Review of ]. ADVANCES IN NUTRITION, 3(5), 687–696.

By: S. Jacobi n & J. Odle n 

Contributors: S. Jacobi n & J. Odle n 

MeSH headings : Animals; Diet; Gastrointestinal Tract / growth & development; Gastrointestinal Tract / immunology; Gastrointestinal Tract / physiopathology; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature / growth & development; Infant, Premature / immunology; Infant, Premature / physiology; Intestinal Mucosa / growth & development; Intestinal Mucosa / immunology; Intestinal Mucosa / physiopathology; Intestines / growth & development; Intestines / immunology; Intestines / physiopathology; Milk, Human / metabolism; Nutritional Requirements; Nutritional Support; Probiotics
TL;DR: The role of specific amino acids (arginine, glutamine, glutamate, and threonine), fatty acids (long chain polyunsaturated, medium chain, and short chain), various prebiotic carbohydrates, and probiotics that have been examined in the suckling piglet model of intestinal health are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Dietary Arachidonate Differentially Alters Desaturase-Elongase Pathway Flux and Gene Expression in Liver and Intestine of Suckling Pigs

The Journal of Nutrition, 141(4), 548–553.

By: S. Jacobi n, X. Lin n, B. Corl n, H. Hess n, R. Harrell n & J. Odle n 

Contributors: S. Jacobi n, X. Lin n, B. Corl n, H. Hess n, R. Harrell n & J. Odle n 

MeSH headings : Acetyltransferases / genetics; Acetyltransferases / metabolism; Animals; Animals, Suckling; Arachidonic Acid / administration & dosage; Delta-5 Fatty Acid Desaturase; Fatty Acid Desaturases / genetics; Fatty Acid Desaturases / metabolism; Fatty Acid Elongases; Fatty Acids / metabolism; Intestinal Mucosa / metabolism; Linoleoyl-CoA Desaturase / genetics; Linoleoyl-CoA Desaturase / metabolism; Liver / metabolism; Organ Specificity; Protein Transport; RNA, Messenger / analysis; Swine
TL;DR: D dietary ARA regulated the desaturase-elongase pathway in a tissue-specific manner in liver and intestine, and had modest effects on (n-6) fatty acid flux, and intestinal FADS2 activity and mRNA increased. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs

The Journal of Nutritional Biochemistry, 22(11), 1047–1054.

By: X. Lin n, J. Bo n, S. Oliver n, B. Corl n, S. Jacobi n, W. Oliver n, R. Harrell n, J. Odle n 

Contributors: X. Lin n, J. Bo n, S. Oliver n, B. Corl n, S. Jacobi n, W. Oliver n, R. Harrell n, J. Odle n 

MeSH headings : Acetyltransferases / metabolism; Animals; Animals, Newborn; Arachidonic Acid / metabolism; Brain / metabolism; Dietary Fats / administration & dosage; Fatty Acid Desaturases / metabolism; Fatty Acid Elongases; Fatty Acids, Unsaturated / metabolism; Linoleic Acid / metabolism; Linoleic Acids, Conjugated / pharmacology; Liver / metabolism; Swine
TL;DR: Overall, the data show that dietary CLA shifted the distribution of the synthetic products of [U-(13)C]LA between elongation and desaturation in liver and decreased the total synthetic products in brain by inhibiting LA elongation to C20:2n-6. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Polydextrose Enrichment of Infant Formula Demonstrates Prebiotic Characteristics by Altering Intestinal Microbiota, Organic Acid Concentrations, and Cytokine Expression in Suckling Piglets

The Journal of Nutrition, 141(12), 2139–2145.

By: T. Herfel n, S. Jacobi n, X. Lin n, V. Fellner n , D. Walker*, Z. Jouni*, J. Odle n 

Contributors: T. Herfel n, S. Jacobi n, X. Lin n, V. Fellner n , D. Walker*, Z. Jouni*, J. Odle n 

MeSH headings : Animals; Animals, Newborn / growth & development; Bifidobacterium / drug effects; Bifidobacterium / growth & development; Cytokines / drug effects; Cytokines / genetics; Cytokines / metabolism; Food, Fortified; Glucans / administration & dosage; Glucans / analysis; Humans; Infant; Infant Food; Infant Formula / chemistry; Intestines / microbiology; Lactic Acid / analysis; Lactobacillus / drug effects; Lactobacillus / growth & development; Metagenome; Milk, Human / chemistry; Models, Animal; Oligosaccharides / administration & dosage; Oligosaccharides / analysis; Prebiotics; Propionates / analysis; RNA / isolation & purification; RNA, Messenger; Real-Time Polymerase Chain Reaction; Swine
TL;DR: PDX enrichment of infant formula resulted in a prebiotic effect by increasing ileal lactobacilli and propionic and lactic acid concentrations and decreasing pH with associated alterations in ileale cytokine expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Effect of dietary boron on immune function in growing beef steers*

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 94(3), 273–279.

By: R. Fry n, K. Lloyd n, S. Jacobi n, P. Siciliano n , W. Robarge n & J. Spears n

author keywords: cattle; boron; immunoglobulins; cytokines; lymphocytes
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Boron / administration & dosage; Boron / blood; Boron / pharmacology; Cattle / growth & development; Cattle / immunology; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Male; Phytohemagglutinins / immunology; Time Factors; Weight Gain
TL;DR: Results from this study indicate that supplemental B had minimal effects on immune function and did not affect performance of growing steers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Safety evaluation of polydextrose in infant formula using a suckling piglet model

Food and Chemical Toxicology, 47(7), 1530–1537.

By: T. Herfel n, S. Jacobi n, X. Lin n, D. Walker*, Z. Jouni* & J. Odle n 

Contributors: T. Herfel n, S. Jacobi n, X. Lin n, D. Walker*, Z. Jouni* & J. Odle n 

author keywords: Polydextrose; Prebiotic; Infant; Oligosaccharide; Soluble fiber
MeSH headings : Amylases / analysis; Amylases / metabolism; Animals; Animals, Suckling; Blood Cell Count; Blood Chemical Analysis; Body Weight / drug effects; DNA / biosynthesis; Diet; Feces / chemistry; Food Additives / toxicity; Glucans / toxicity; Health Status; Humans; Infant; Infant Food / toxicity; Organ Size / drug effects; Pancreas / drug effects; Pancreas / metabolism; Swine
TL;DR: Polydextrose mimicked other prebiotic carbohydrates and had no adverse effect at the highest tested level 17.0 g PDX/L, equivalent to a dose of 8.35 g/kg of body weight per day. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Enrichment of Intestinal Mucosal Phospholipids with Arachidonic and Eicosapentaenoic Acids Fed to Suckling Piglets Is Dose and Time Dependent

The Journal of Nutrition, 138(11), 2164–2171.

By: H. Hess n, B. Corl n, X. Lin n, S. Jacobi n, R. Harrell n, A. Blikslager n , J. Odle n 

Contributors: H. Hess n, B. Corl n, X. Lin n, S. Jacobi n, R. Harrell n, A. Blikslager n , J. Odle n 

MeSH headings : Animals; Arachidonic Acid / administration & dosage; Arachidonic Acid / pharmacology; Diet; Dose-Response Relationship, Drug; Drug Administration Schedule; Eicosapentaenoic Acid / administration & dosage; Eicosapentaenoic Acid / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Lactase / metabolism; Swine
TL;DR: D doses demonstrate a dose-dependent response of intestinal mucosal phospholipid ARA concentration to dietary ARA with nearly full enrichment attained within 8 d of feeding formula containing ARA and that supra-physiologic supplementation of ARA is not detrimental to growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Ontogeny of Carnitine Palmitoyltransferase I Activity, Carnitine-Km, and mRNA Abundance in Pigs throughout Growth and Development

The Journal of Nutrition, 137(4), 898–903.

By: P. Lyvers Peffer n, X. Lin n, S. Jacobi n, L. Gatlin n, J. Woodworth * & J. Odle n 

Contributors: P. Peffer n, X. Lin n, S. Jacobi n, L. Gatlin n, J. Woodworth * & J. Odle n 

MeSH headings : Aging / metabolism; Animal Feed; Animals; Animals, Newborn; Animals, Suckling / metabolism; Carnitine / metabolism; Carnitine O-Palmitoyltransferase / genetics; Carnitine O-Palmitoyltransferase / metabolism; Female; Gene Expression; Kinetics; Lipid Metabolism / physiology; Liver / metabolism; Male; Muscle, Skeletal / metabolism; Osmolar Concentration; RNA, Messenger / metabolism; Swine / growth & development; Swine / metabolism
TL;DR: It is suggested that postnatal increases in CPT I activity during the suckling period are accompanied by increased tissue carnitine, and the lack of hepatic C PT I mRNA induction and low activity reported in both tissues prior to 1 wk of age may limit postnatal lipid utilization during the piglet's transition to extra-uterine life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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