2008 journal article

Dilute suspension flow with nanoparticle deposition in a representative nasal airway model

PHYSICS OF FLUIDS, 20(1).

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

TL;DR: The understanding and quantitative assessment of mixture flow fields and local nanoparticle wall concentrations in nasal airways with a thin mucus layer are very important for estimating the health risks of inhaled toxic aerosols, determining proper drug-aerosol delivery to target sites such as the olfactory regions and developing algebraic transfer functions for overall nasal dose-response analyses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Jetting and detonation initiation in shock induced collapse of nanometer-scale voids

JOURNAL OF PHYSICAL CHEMISTRY C, 112(16), 6263–6270.

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 20(3), 294–309.

By: C. Kleinstreuer n, H. Shi* & Z. Zhang n

author keywords: computer simulation; droplet spray formation; pMDI performance; droplet transport/deposition; human upper airways; controlled air-particle stream; targeted drug-aerosol transport/deposition
MeSH headings : Aerosol Propellants / chemistry; Aerosols; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / chemistry; Computer Simulation; Drug Delivery Systems / instrumentation; Equipment Design; Humans; Hydrocarbons, Fluorinated / chemistry; Inhalation Spacers; Metered Dose Inhalers; Models, Biological; Motion; Particle Size; Pressure; Reproducibility of Results; Respiratory System / anatomy & histology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

JOURNAL OF AEROSOL SCIENCE, 38(4), 398–419.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

author keywords: human nasal cavity; inertial particle decomposition; computer analysis; wall roughness
TL;DR: Considering drug–aerosol targeting, an optimal impaction parameter value exists which generates for normal inlet conditions the largest deposition in desired areas, e.g., the middle meatus, inferior meatus and olfactory regions, however, the absolute deposition efficiencies are very small because particles hardly reach those regions due to the complex nasal geometric structures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation and analysis of high-speed droplet spray dynamics

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 129(5), 621–633.

By: H. Shi n & C. Kleinstreuer n

Source: Web Of Science
Added: August 6, 2018

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