Works (7)

Updated: July 5th, 2023 15:54

2014 journal article

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors


By: A. Charoenpanich n, M. Wall n, C. Tucker*, D. Andrews*, D. Lalush n, D. Dirschl*, E. Loboa n

MeSH headings : Aged, 80 and over; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cell Separation; Female; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Neovascularization, Physiologic / genetics; Oligonucleotide Array Sequence Analysis; Osteogenesis / genetics; Osteoporosis, Postmenopausal / genetics; Osteoporosis, Postmenopausal / pathology; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Signal Transduction / genetics; Stress, Mechanical; Tensile Strength; Tissue Donors; White People
TL;DR: It is demonstrated that hMSC from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in the expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Microarray Analysis of Human Adipose-Derived Stem Cells in Three-Dimensional Collagen Culture: Osteogenesis Inhibits Bone Morphogenic Protein and Wnt Signaling Pathways, and Cyclic Tensile Strain Causes Upregulation of Proinflammatory Cytokine Regulators and Angiogenic Factors

TISSUE ENGINEERING PART A, 17(21-22), 2615–2627.

By: A. Charoenpanich n, M. Wall n, C. Tucker*, D. Andrews*, D. Lalush n & E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adult; Angiogenesis Inducing Agents / metabolism; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Cells, Cultured; Collagen / metabolism; Cytokines / genetics; Cytokines / metabolism; Humans; Insulin-Like Growth Factor I / genetics; Middle Aged; Oligonucleotide Array Sequence Analysis / methods; Osteogenesis / genetics; Osteogenesis / physiology; Platelet-Derived Growth Factor / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Stem Cells / cytology; Stem Cells / metabolism; Wnt Signaling Pathway / genetics; Wnt Signaling Pathway / physiology
TL;DR: This first study to investigate the effects of both 3D culture and mechanical load on hASC osteogenic differentiation and response to mechanical stimuli identified specific genes and pathways associated with mechanical response and osteogenic potential of hASC, thus providing significant information toward improved understanding of its use for functional bone tissue engineering applications. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Modulation of collagen gel compaction by extracellular ATP is MAPK and NF-kappa B pathways dependent


By: J. Qi n, L. Chi*, J. Wang*, R. Sumanasinghe*, M. Wall*, M. Tsuzaki*, A. Banes n

author keywords: ATP; Collagen gel; P2 receptor; bone; NF-kappa B; MAPK; Prestress
MeSH headings : 3T3 Cells; Adenosine Triphosphate / metabolism; Adenosine Triphosphate / pharmacology; Adenylyl Cyclases / metabolism; Animals; Base Sequence; Calmodulin / metabolism; Collagen / genetics; Collagen / metabolism; DNA Primers / genetics; Extracellular Fluid / metabolism; Gels; Gene Expression / drug effects; Kinetics; MAP Kinase Signaling System; Mechanotransduction, Cellular; Mice; Models, Biological; Myosin-Light-Chain Kinase / metabolism; NF-kappa B / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Receptors, Purinergic P2 / metabolism; Stress, Mechanical
TL;DR: The results from the present and previous studies indicate that extracellular ATP may act as a negative feedback modulator in the mechanotransduction system since mechanical stimuli increase ATP release from stimulated cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 review

Isolation of human mesenchymal stem cells from bone and adipose tissue

[Review of ]. Stem cell culture, 86, 257–278.

By: S. Bernacki, M. Wall & E. Loboa

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Effects of oxygen plasma treatment on adipose-derived human mesenchymal stem cell adherence to poly(L-lactic acid) scaffolds


By: A. Hanson n, M. Wall n, B. Pourdeyhimi n & E. Loboa n

author keywords: hydrophilicity; non-woven PLLA scaffold; cell morphology; cell viability; melt-blown PLLA scaffold
MeSH headings : Adipocytes / cytology; Cell Adhesion / drug effects; Cell Survival; Cells, Cultured; Humans; Lactic Acid / chemistry; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Microscopy, Electron, Scanning; Oxygen / chemistry; Oxygen / pharmacology; Polyesters; Polymers / chemistry; Tissue Scaffolds / chemistry
TL;DR: Enhanced cell adhesion to non-woven poly(L-lactic acid) (PLLA) scaffolds using oxygen plasma treatment to increase surface hydroxyl groups and thereby enhance substrate hydrophilicity was enhanced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells

TISSUE ENGINEERING, 13(6), 1291–1298.

By: M. Wall n, S. Bernacki n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Adipogenesis / physiology; Adult; Cell Culture Techniques / methods; Cell Differentiation; Cells, Cultured; Female; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / physiology; Middle Aged; Osteocytes / cytology; Osteocytes / physiology; Osteogenesis / physiology; Tissue Engineering / methods
TL;DR: The results of this study indicate that adipose-derived hMSCs are capable of both adipogenic and osteogenic differentiation through 10 passages (34 population doublings) but that osteogenic differentiate may start to dominate at later passages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain


By: M. Wall n, A. Rachlin, C. Otey* & E. Loboa*

author keywords: adipose-derived adult stem cells; mechanobiology; Eps8; actin cytoskeleton; mesenchymal stem cells
MeSH headings : Actins / metabolism; Adaptor Proteins, Signal Transducing; Adipose Tissue / cytology; Adipose Tissue / metabolism; Adult; Adult Stem Cells / metabolism; Cell Lineage / genetics; Cell Shape; Cells, Cultured; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; Female; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / genetics; Middle Aged; Osteogenesis / genetics; Phosphoproteins / genetics; Phosphoproteins / metabolism; Protein Isoforms / metabolism; RNA Interference; RNA, Messenger / metabolism; RNA, Small Interfering / metabolism; Stress Fibers / metabolism; Stress, Mechanical; Up-Regulation
TL;DR: It is shown that palladin was expressed by hADAS cells and was modulated during osteogenic differentiation and in response to cyclic tensile strain, and that knocking down the palladin gene resulted in decreased actin stress fibers and decreased protein levels of Eps8. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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