@article{fry_heinsohn_2002, title={Environment dependence of mutational parameters for viability in Drosophila melanogaster}, volume={161}, number={3}, journal={Genetics}, author={Fry, J. D. and Heinsohn, S. L.}, year={2002}, pages={1155–1167} } @article{fry_keightley_heinsohn_nuzhdin_1999, title={New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster}, volume={96}, ISSN={["0027-8424"]}, DOI={10.1073/pnas.96.2.574}, abstractNote={ The genomic rate and distribution of effects of deleterious mutations are important parameters in evolutionary theory. The most detailed information comes from the work of Mukai and Ohnishi, who allowed mutations to accumulate on Drosophila melanogaster second chromosomes, shielded from selection and recombination by being maintained heterozygous in males. Averaged over studies, the estimated rate of nonlethal viability mutations per second chromosome per generation under an equal-effects model, U BM , was 0.12, suggesting a high genomic mutation rate. We have performed a mutation-accumulation experiment similar to those of Mukai and Ohnishi, except that three large homozygous control populations were maintained. Egg-to-adult viability of 72 nonlethal mutation-accumulation (MA) lines and the controls was assayed after 27–33 generations of mutation accumulation. The rate of decline in mean viability was significantly lower than observed by Mukai, and the rate of increase in among-line variance was significantly higher. Our U BM estimate of 0.02 is much lower than the previous estimates. Our results suggest that the rate of mutations that detectably reduce viability may not be much greater than the lethal mutation rate (0.01 in these lines), but the results also are consistent with models that include many mutations with very small effects. }, number={2}, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Fry, JD and Keightley, PD and Heinsohn, SL and Nuzhdin, SV}, year={1999}, month={Jan}, pages={574–579} } @article{gurganus_fry_nuzhdin_pasyukova_lyman_mackay_1998, title={Genotype-environment interaction at quantitative trait loci affecting sensory bristle number in Drosophila melanogaster}, volume={149}, number={4}, journal={Genetics}, author={Gurganus, M. C. and Fry, J. D. and Nuzhdin, S. V. and Pasyukova, E. G. and Lyman, R. F. and MacKay, T. F. C.}, year={1998}, month={Aug}, pages={1883–1898} } @article{fry_heinsohn_mackay_1998, title={Heterosis for viability, fecundity, and male fertility in Drosophila melanogaster: Comparison of mutational and standing variation}, volume={148}, number={3}, journal={Genetics}, author={Fry, J. D. and Heinsohn, S. L. and MacKay, T. F. C.}, year={1998}, pages={1171–1188} } @article{fry_nuzhdin_pasyukova_mckay_1998, title={QTL mapping of genotype-environment interaction for fitness in Drosophila melanogaster}, volume={71}, ISSN={["1469-5073"]}, DOI={10.1017/S0016672398003176}, abstractNote={A fundamental assumption of models for the maintenance of genetic variation by environmental heterogeneity is that selection favours alternative alleles in different environments. It is not clear, however, whether such antagonistic pleiotropy is common. We mapped quantitative trait loci (QTLs) causing variation for reproductive performance in each of three environmental treatments among a set of 98 recombinant inbred (RI) lines derived from a cross between two D. melanogaster laboratory strains. The three treatments were standard medium at 25°C, ethanol-supplemented medium at 25°C, and standard medium at 18°C. The RI lines showed highly significant genotype–environment interaction for the fitness measure. Of six QTLs with significant effects on fitness in at least one of the environments, five had significantly different effects at the different temperatures. In each case, the QTL by temperature interaction arose because the QTL had stronger effects at one temperature than at the other. No evidence for QTLs with opposite fitness effects in different environments was found. These results, together with those of recent studies of crop plants, suggest that antagonistic pleiotropy is a relatively uncommon form of genotype–environment interaction for fitness, but additional studies of natural populations are needed to confirm this conclusion.}, number={2}, journal={GENETICS RESEARCH}, author={Fry, JD and Nuzhdin, SV and Pasyukova, EG and Mckay, TFC}, year={1998}, month={Apr}, pages={133–141} } @article{kawecki_barton_fry_1997, title={Mutational collapse of fitness in marginal habitats and the evolution of ecological specialisation}, volume={10}, ISSN={["1420-9101"]}, DOI={10.1007/s000360050032}, number={3}, journal={JOURNAL OF EVOLUTIONARY BIOLOGY}, author={Kawecki, TJ and Barton, NH and Fry, JD}, year={1997}, month={May}, pages={407–429} } @article{fry_heinsohn_mackay_1997, title={The contribution of new mutations to genotype-environment interaction for fitness in Drosophila melanogaster}, volume={50}, DOI={10.2307/2410700}, number={6}, journal={Evolution}, author={Fry, J. D. and Heinsohn, S. L. and MacKay, T. F.C.}, year={1997}, pages={2316–2327} } @article{fry_1996, title={The evolution of host specialization: Are trade-offs overrated?}, volume={148}, journal={American Naturalist}, author={Fry, J. D.}, year={1996}, pages={84} } @article{fry_deronde_mackay_1995, title={Polygenic mutation in Drosophila melanogaster: Genetic analysis of selection lines}, volume={139}, number={3}, journal={Genetics}, author={Fry, J. D. and DeRonde, K. A. and Mackay, T. F. C.}, year={1995}, pages={1293} } @article{fry_1993, title={The "general vigor" problem: Can antagonistic pleiotropy be detected when genetic covariances are positive?}, volume={47}, DOI={10.2307/2410143}, number={1}, journal={Evolution}, author={Fry, J. D.}, year={1993}, pages={327} }