@article{whang_hunt_wrench_hockney_farin_tonelli_2007, title={Nonoxynol-9-alpha-cyclodextrin inclusion compound and its application for the controlled release of nonoxynol-9 spermicide}, volume={106}, ISSN={["1097-4628"]}, DOI={10.1002/app.26956}, abstractNote={AbstractNonoxynol‐9 (N‐9) is the most active ingredient in commercially available spermicidal products in the United States. There are many applications of cyclodextrin inclusion complexes (CD‐ICs), but there are no reported studies investigating the formation of and controlled release from a N‐9 spermicide‐CD‐IC. We have successfully formed the inclusion compound between N‐9 and α‐CD using a solution‐heating technique. The N‐9‐α‐CD‐IC was characterized by Fourier Transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, thermogravimetric analysis, and wide angle X‐ray diffraction observations. Silicone elastomer (SILASTIC MDX4‐4210) film embedded with crystalline N‐9‐α‐CD‐IC was prepared and evaluated for its efficacy in the controlled release of N‐9 spermicide against bovine sperm. Silicone elastomer with N‐9‐α‐CD‐IC was as successful in reducing the motility and viability of bovine spermtazoa as silicone elastomer swollen with an equivalent amount of neat N‐9. The permeability of the flexible silicone elastomer apparently enables the N‐9 spermicide to diffuse from its embedded inclusion complex crystals to contact, immobilize, and kill bovine sperm cells. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007}, number={6}, journal={JOURNAL OF APPLIED POLYMER SCIENCE}, author={Whang, Hyun Suk and Hunt, Marcus A. and Wrench, Nicola and Hockney, Jessica E. and Farin, Charlotte E. and Tonelli, Alan E.}, year={2007}, month={Dec}, pages={4104–4109} }