David M. Reif

Works (12)

Updated: July 5th, 2023 15:51

2016 journal article

Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space

Toxicological Sciences, 152(2), 323–339.

By: R. Judson, K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson*, A. Planchart n , C. Mattingly n , C. Winkler *, D. Reif n  & S. Kullman n 

Contributors: A. Watson, A. Planchart n , C. Mattingly n , C. Winkler *, D. Reif n  & S. Kullman n 

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR: It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

Reproductive Toxicology (Elmsford, N.Y.), 55, 3–10.

By: N. Ducharme, D. Reif, J. Gustafsson & M. Bondesson

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

TOXICOLOGICAL SCIENCES, 148(2), 341–354.

By: M. Rebuli n, L. Camacho *, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n 

Contributors: M. Rebuli n, L. Camacho *, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n 

author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
TL;DR: No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates

PLOS ONE, 10(4).

By: E. Kollitz n, G. Zhang  n, M. Hawkins n, G. Whitfield*, D. Reif n  & S. Kullman n 

Contributors: E. Kollitz n, G. Zhang  n, M. Hawkins n, G. Whitfield*, D. Reif n  & S. Kullman n 

MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
TL;DR: This study compares molecular activities of vitamin D receptors (VDR) from basal species that diverged at key points in vertebrate evolution in order to infer derived and ancestral VDR functions of teleost paralogs and suggests that 1, 25D3 acts as a partial agonist in basal species. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Toxicity testing in the 21st century beyond environmental chemicals

Altex-Alternatives to Animal Experimentation, 32(3), 171–181.

By: C. Rovida, S. Asakura, M. Daneshian, H. Hofman-Huether, M. Leist, L. Meunier, D. Reif, A. Rossi ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Hierarchical Dose-Response Modeling for High-Throughput Toxicity Screening of Environmental Chemicals

BIOMETRICS, 70(1), 237–246.

By: A. Wilson  n, D. Reif n  & B. Reich n 

Contributors: A. Wilson  n, D. Reif n  & B. Reich n 

author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR: This work proposes a semiparametric Bayesian model that borrows strength across chemicals and assays and demonstrates that the hierarchical method provides more accurate estimates of the probability of response, efficacy, and potency than separate curve estimation in a simulation study. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Multidimensional In Vivo Hazard Assessment Using Zebrafish

Toxicological Sciences, 137(1), 212–233.

By: L. Truong, D. Reif, L. St Mary, M. Geier, H. Truong & R. Tanguay

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.

By: D. Filer *, H. Patisaul n , T. Schug*, D. Reif n  & K. Thayer *

Contributors: D. Filer *, H. Patisaul n , T. Schug*, D. Reif n  & K. Thayer *

MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR: Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 article

A Comparison of Analytical Methods for Genetic Association Studies (vol 32, pg 767, 2008)

Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2009, December). GENETIC EPIDEMIOLOGY, Vol. 33, pp. 751–751.

By: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *

Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *

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Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

A Comparison of Analytical Methods for Genetic Association Studies

GENETIC EPIDEMIOLOGY, 32(8), 767–778.

By: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *

Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *

author keywords: genetic association study; epistasis; multifactor dimensionality reduction; grammatical evolution neural networks; focused interaction testing framework
MeSH headings : Data Interpretation, Statistical; Epistasis, Genetic; Genetic Linkage; Genetic Techniques; Genome; Humans; Models, Genetic; Models, Statistical; Models, Theoretical; Neural Networks, Computer; Phenotype; Probability; Regression Analysis; Software
TL;DR: This study compares the performance of six analytical approaches to detect both main effects and gene‐gene interactions in a range of genetic models and demonstrates the strengths and weaknesses of each and illustrates the importance of continued methods development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 review

Novel methods for detecting epistasis in pharmacogenomics studies

[Review of ]. Pharmacogenomics, 8(9), 1229–1241.

By: A. Motsinger, M. Ritchie & D. Reif

Source: NC State University Libraries
Added: August 6, 2018

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