Works (1)
Updated: July 5th, 2023 16:04
1997 journal article
Benzene-induced hematotoxicity and bone marrow compensation in B6C3F1 mice
FUNDAMENTAL AND APPLIED TOXICOLOGY, 36(2), 119–129.
MeSH headings : Animals; Benzene / toxicity; Blood Cell Count; Bone Marrow / drug effects; Bone Marrow / pathology; Bromodeoxyuridine; Cell Differentiation / drug effects; Cell Division / drug effects; Chromatography, High Pressure Liquid; Flow Cytometry; Hematologic Diseases / blood; Hematologic Diseases / chemically induced; Hematologic Diseases / pathology; Hematopoiesis / drug effects; Hematopoietic Stem Cells; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; S Phase / physiology; Spectrophotometry, Infrared; Spleen / cytology; Spleen / drug effects; Stem Cells / drug effects
TL;DR:
The increased replication of primitive progenitor cells in concert with the reported genotoxicity induced by benzene provides the components necessary for producing an increased incidence of lymphoma in mice and is proposed as a biologically plausible mechanism for benzene-induced leukemia in humans exposed to high concentrations of benzene.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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