Works (4)
Updated: July 5th, 2023 15:54
2011 journal article
Beyond the Random Coil: Stochastic Conformational Switching in Intrinsically Disordered Proteins
STRUCTURE, 19(4), 566–576.
TL;DR:
Surprisingly, two proteins, neuroligin and the NMDAR-2B glutamate receptor, were observed to stochastically switch among distinct conformational states despite the fact that they appeared intrinsically disordered by other measures.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Optimizing Methods to Recover Absolute FRET Efficiency from Immobilized Single Molecules
BIOPHYSICAL JOURNAL, 99(3), 961–970.
MeSH headings : Animals; Base Sequence; DNA / chemistry; DNA / genetics; Disks Large Homolog 4 Protein; Fluorescence Resonance Energy Transfer / methods; Immobilized Proteins / chemistry; Intracellular Signaling Peptides and Proteins / chemistry; Membrane Proteins / chemistry; Molecular Sequence Data; Mutant Proteins / chemistry; Photobleaching; Rats; Reference Standards
TL;DR:
This is the first systematic study of methods to recover the true FRET efficiency using DNA rulers with known fluorophore separations and per-molecule gamma-normalization was the most effective depending on how it was applied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 17(3), 318–U84.
MeSH headings : Animals; Calcium / metabolism; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Fluorescence Resonance Energy Transfer; Protein Binding; Rats; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; SNARE Proteins / chemistry; SNARE Proteins / genetics; SNARE Proteins / metabolism; Synaptotagmin I / chemistry; Synaptotagmin I / genetics; Synaptotagmin I / metabolism
TL;DR:
An experimentally determined model of the elusive Syt1–SNARE complex is obtained using a multibody docking approach with 34 FRET-derived distances as restraints, suggesting a common mechanism by which the interaction between synaptotagmins and SNAREs aids in Ca2+-triggered fusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1 : 1 syntaxin/SNAP-25 complex
STRUCTURE, 16(2), 308–320.
MeSH headings : Fluorescence Resonance Energy Transfer; Lipid Bilayers / metabolism; Protein Structure, Tertiary; Qa-SNARE Proteins / chemistry; Qa-SNARE Proteins / metabolism; R-SNARE Proteins / metabolism; SNARE Proteins / metabolism; Synaptosomal-Associated Protein 25 / chemistry; Synaptosomal-Associated Protein 25 / metabolism
TL;DR:
The structure of the 1:1 syntaxin/SNAP-25 binary complex is variable, with states changing on the second timescale, and one state corresponds to a parallel three-helix bundle, whereas other states show one of the SNAP-25 SNARE domains dissociated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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