Works (4)
Updated: July 5th, 2023 15:54
2012 journal article
Long-Term Efficacy Following Readministration of an Adeno-Associated Virus Vector in Dogs with Glycogen Storage Disease Type Ia
HUMAN GENE THERAPY, 23(4), 407–418.
MeSH headings : Animals; Dependovirus / genetics; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Hypoglycemia / therapy; Liver / metabolism
TL;DR:
Preclinical data support the further translation of AAV vector-mediated gene therapy in GSD-Ia and support the demonstrated risk for recurrent hypoglycemia and mortality from waning efficacy of the AAV2/9 vector.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia
GENE THERAPY, 19(4), 443–452.
author keywords: glycogen storage disease; von Gierke disease; glucose-6-phosphatase; adenovirus vector; renal dysfunction
MeSH headings : Adenoviridae / genetics; Animals; Body Weight; Dog Diseases / therapy; Dogs; Genetic Therapy / adverse effects; Genetic Therapy / methods; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / therapy; Glycogen Storage Disease Type I / veterinary; Hypoglycemia / complications; Hypoglycemia / prevention & control
TL;DR:
Administration of a serotype 2 HDAd vector prolonged survival in one GSD-Ia dog to 12 years of age and 36 months of age in the other, but the persistence of long-term complications limited HDAd vectors in the canine model for GSD -Ia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia
MOLECULAR THERAPY, 16(4), 665–672.
MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / enzymology; Hypoglycemia / therapy; Liver Glycogen / metabolism; Mice; Mice, Knockout
TL;DR:
The AAV2/8 vector uniquely prevented hypoglycemia during fasting and fully corrected liver G6Pase deficiency in GSD-Ia mice and dogs, and support the further preclinical development of AAV vector-mediated gene therapy for GSD -Ia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Simplified hypoosmotic swelling testing (HOST) of fresh and frozen-thawed canine spermatozoa
ANIMAL REPRODUCTION SCIENCE, 104(2-4), 450–455.
author keywords: canine; sperm; sperm membrane; hypoosmotic swelling test
MeSH headings : Animals; Cell Membrane / physiology; Cryopreservation / veterinary; Dogs / physiology; Male; Osmotic Pressure; Semen Preservation / veterinary; Sperm Motility / physiology; Spermatozoa / physiology; Statistics, Nonparametric
TL;DR:
Based on the results of this study, it is recommended to decrease the incubation time of the HOST for canine spermatozoa to as short a period as 1 min, to encourage the application of this relatively simple and inexpensive test of canine sperm membrane function in a clinical setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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