@article{mackay_heinsohn_lyman_moehring_morgan_rollmann_2005, title={Genetics and genomics of Drosophila mating behavior}, volume={102}, ISSN={["0027-8424"]}, DOI={10.1073/pnas.0501986102}, abstractNote={
            The first steps of animal speciation are thought to be the development of sexual isolating mechanisms. In contrast to recent progress in understanding the genetic basis of postzygotic isolating mechanisms, little is known about the genetic architecture of sexual isolation. Here, we have subjected
            Drosophila melanogaster
            to 29 generations of replicated divergent artificial selection for mating speed. The phenotypic response to selection was highly asymmetrical in the direction of reduced mating speed, with estimates of realized heritability averaging 7%. The selection response was largely attributable to a reduction in female receptivity. We assessed the whole genome transcriptional response to selection for mating speed using Affymetrix GeneChips and a rigorous statistical analysis. Remarkably, >3,700 probe sets (21% of the array elements) exhibited a divergence in message levels between the Fast and Slow replicate lines. Genes with altered transcriptional abundance in response to selection fell into many different biological process and molecular function Gene Ontology categories, indicating substantial pleiotropy for this complex behavior. Future functional studies are necessary to test the extent to which transcript profiling of divergent selection lines accurately predicts genes that directly affect the selected trait.
          }, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Mackay, TFC and Heinsohn, SL and Lyman, RF and Moehring, AJ and Morgan, TJ and Rollmann, SM}, year={2005}, month={May}, pages={6622–6629} }
 @article{borras_morozova_heinsohn_lyman_mackay_anholt_2003, title={Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)}, volume={163}, number={2}, journal={Genetics}, author={Borras, T. and Morozova, T. V. and Heinsohn, S. L. and Lyman, R. F. and Mackay, T. F. C. and Anholt, R. R. H.}, year={2003}, month={Feb}, pages={637–645} }
 @article{fry_heinsohn_2002, title={Environment dependence of mutational parameters for viability in Drosophila melanogaster}, volume={161}, number={3}, journal={Genetics}, author={Fry, J. D. and Heinsohn, S. L.}, year={2002}, pages={1155–1167} }
 @article{fry_keightley_heinsohn_nuzhdin_1999, title={New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster}, volume={96}, ISSN={["0027-8424"]}, DOI={10.1073/pnas.96.2.574}, abstractNote={
            The genomic rate and distribution of effects of deleterious mutations are important parameters in evolutionary theory. The most detailed information comes from the work of Mukai and Ohnishi, who allowed mutations to accumulate on
            Drosophila melanogaster
            second chromosomes, shielded from selection and recombination by being maintained heterozygous in males. Averaged over studies, the estimated rate of nonlethal viability mutations per second chromosome per generation under an equal-effects model,
            U
            BM
            , was 0.12, suggesting a high genomic mutation rate. We have performed a mutation-accumulation experiment similar to those of Mukai and Ohnishi, except that three large homozygous control populations were maintained. Egg-to-adult viability of 72 nonlethal mutation-accumulation (MA) lines and the controls was assayed after 27–33 generations of mutation accumulation. The rate of decline in mean viability was significantly lower than observed by Mukai, and the rate of increase in among-line variance was significantly higher. Our
            U
            BM
            estimate of 0.02 is much lower than the previous estimates. Our results suggest that the rate of mutations that detectably reduce viability may not be much greater than the lethal mutation rate (0.01 in these lines), but the results also are consistent with models that include many mutations with very small effects.
          }, number={2}, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Fry, JD and Keightley, PD and Heinsohn, SL and Nuzhdin, SV}, year={1999}, month={Jan}, pages={574–579} }
 @article{fry_heinsohn_mackay_1998, title={Heterosis for viability, fecundity, and male fertility in Drosophila melanogaster: Comparison of mutational and standing variation}, volume={148}, number={3}, journal={Genetics}, author={Fry, J. D. and Heinsohn, S. L. and MacKay, T. F. C.}, year={1998}, pages={1171–1188} }
 @article{fry_heinsohn_mackay_1997, title={The contribution of new mutations to genotype-environment interaction for fitness in Drosophila melanogaster}, volume={50}, DOI={10.2307/2410700}, number={6}, journal={Evolution}, author={Fry, J. D. and Heinsohn, S. L. and MacKay, T. F.C.}, year={1997}, pages={2316–2327} }