2008 journal article

Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation


By: D. Dorman n, M. Struve n, B. Wong*, E. Gross*, C. Parkinson*, G. Willson*, Y. Tan*, J. Campbell* ...

MeSH headings : Acetaldehyde / toxicity; Air Pollutants / toxicity; Animals; Benchmarking; Cell Proliferation / drug effects; Cross-Linking Reagents / toxicity; DNA / chemistry; DNA / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; No-Observed-Adverse-Effect Level; Olfactory Mucosa / drug effects; Olfactory Mucosa / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Protein Binding / drug effects; Proteins / chemistry; Proteins / drug effects; Rats; Rats, Inbred F344; Rhinitis / chemically induced; Rhinitis / pathology
TL;DR: The severity of the ONL demonstrated dose-and temporal-dependent behaviors, with minimal effects noted at 150–500 ppm acetaldehyde and moderately severe lesions seen in the highest exposure group, with increased lesion severity and extent as the exposure duration increased. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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