@article{schkoda_horman_witchey_jansson_macari_patisaul_2023, title={Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat}, volume={5}, ISSN={["2673-3080"]}, DOI={10.3389/ftox.2023.1216388}, abstractNote={Introduction: Accumulating evidence reveals that endocrine disrupting chemicals (EDCs) can disrupt aspects of metabolic programming, suggesting that skeletal development may be at risk, a possibility that is rarely examined. The commercial flame retardant (FR) mixture, Firemaster 550 (FM 550), has repeatedly been shown to negatively influence metabolic programming, raising concerns that skeletal integrity may consequently be impaired. We have previously shown that gestational and lactational exposure to 1,000 µg FM 550 negatively affected sex-specific skeletal traits in male, but not female, rats assessed at 6 months of age. Whether this outcome is primarily driven by the brominated (BFR) or organophosphate ester (OPFR) portions of the mixture or the effects persist to older ages is unknown.}, journal={FRONTIERS IN TOXICOLOGY}, author={Schkoda, Stacy and Horman, Brian and Witchey, Shannah K. and Jansson, Anton and Macari, Soraia and Patisaul, Heather B.}, year={2023}, month={Jul} }
 @article{agarwalla_ogunnaike_ahn_froehlich_jansson_ligler_dotti_brudno_2022, title={Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells}, volume={3}, ISSN={["1546-1696"]}, DOI={10.1038/s41587-022-01245-x}, abstractNote={Despite their clinical success, chimeric antigen receptor (CAR)-T cell therapies for B cell malignancies are limited by lengthy, costly and labor-intensive ex vivo manufacturing procedures that might lead to cell products with heterogeneous composition. Here we describe an implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release (MASTER) that streamlines in vivo CAR-T cell manufacturing and reduces processing time to a single day. When seeded with human peripheral blood mononuclear cells and CD19-encoding retroviral particles, MASTER provides the appropriate interface for viral vector-mediated gene transfer and, after subcutaneous implantation, mediates the release of functional CAR-T cells in mice. We further demonstrate that in vivo-generated CAR-T cells enter the bloodstream and control distal tumor growth in a mouse xenograft model of lymphoma, showing greater persistence than conventional CAR-T cells. MASTER promises to transform CAR-T cell therapy by fast-tracking manufacture and potentially reducing the complexity and resources needed for provision of this type of therapy.}, journal={NATURE BIOTECHNOLOGY}, author={Agarwalla, Pritha and Ogunnaike, Edikan A. and Ahn, Sarah and Froehlich, Kristen A. and Jansson, Anton and Ligler, Frances S. and Dotti, Gianpietro and Brudno, Yevgeny}, year={2022}, month={Mar} }
 @article{akurati_jansson_jones_ghosh_2021, title={Deformation mechanisms in ice-templated alumina-epoxy composites for the different directions of uniaxial compressive loading}, volume={16}, ISSN={["2589-1529"]}, DOI={10.1016/j.mtla.2021.101054}, abstractNote={The ice-templating technique enables the fabrication of multilayered ceramic-based composite materials. Very little is known on the inelastic deformation mechanisms that evolve in this class of composite materials under compressive loading conditions and cause macroscopic failure. The current investigation is motivated by a recent study by the authors, which revealed that the uniaxial compressive response of ice-templated ceramic–polymer composites is strongly dependent on the loading direction relative to the layer orientation. The current investigation reveals that the inelastic deformation mechanisms in ice-templated alumina–epoxy composites are strongly influenced by the compressive loading orientation relative to the growth direction of ice crystals. The deformation mechanisms were investigated for the loading directions of 0° (parallel to the growth direction), 45° (to the growth direction), and 90° (to the growth direction). For 0°, kink band formation and longitudinal splitting were observed to be the primary strength limiting mechanisms. Kink band formation could be the primary strength limiting factor and responsible for the catastrophic-type compressive failure response. For the loading directions of 45° and 90°, interface delamination and fracture within the lamella walls and across the alumina–epoxy interfaces were the main deformation mechanisms. These mechanisms significantly reduced the compressive strength but attributed progressive-type failure behavior in ice-templated composites. The knowledge of the inelastic deformation mechanisms in ice-templated ceramic–polymer composites under compressive loading is vital for an improved understanding of structure–mechanical property relationships and hierarchical materials design.}, journal={MATERIALIA}, author={Akurati, Sashanka and Jansson, Anton and Jones, Jacob L. and Ghosh, Dipankar}, year={2021}, month={May} }
 @article{morgan_andie m. o'connell_jansson_peterson_mahle_eldred_gao_parsons_2021, title={Stretchable and Multi-Metal-Organic Framework Fabrics Via High-Yield Rapid Sorption-Vapor Synthesis and Their Application in Chemical Warfare Agent Hydrolysis}, volume={13}, ISSN={["1944-8252"]}, url={https://doi.org/10.1021/acsami.1c07366}, DOI={10.1021/acsami.1c07366}, abstractNote={Protocols to create metal-organic framework (MOF)/polymer composites for separation, chemical capture, and catalytic applications currently rely on relatively slow solution-based processing to form single MOF composites. Here, we report a rapid, high-yield sorption-vapor method for direct simultaneous growth of single and multiple MOF materials onto untreated flexible and stretchable polymer fibers and films. The synthesis utilizes favorable reactant absorption into polymers coupled with rapid vapor-driven MOF crystallization to form high surface area (>250 m2/gcomposite) composites, including UiO-66-NH2, HKUST-1, and MOF-525 on spandex, nylon, and other fabrics. The resulting composites are robust and maintain their functionality even after stretching. Stretchable MOF fabrics enable rapid solid-state hydrolysis of the highly toxic chemical warfare agent soman and paraoxon-methyl simulant. We show that this approach can readily be scaled by solution spray-coating of MOF precursors and to large area substrates.}, number={26}, journal={ACS APPLIED MATERIALS & INTERFACES}, publisher={American Chemical Society (ACS)}, author={Morgan, Sarah E. and Andie M. O'Connell and Jansson, Anton and Peterson, Gregory W. and Mahle, John J. and Eldred, Tim B. and Gao, Wenpei and Parsons, Gregory N.}, year={2021}, month={Jul}, pages={31279–31284} }