Alison Motsinger-Reif

Fleming, J. F., House, J. S., Chappel, J. R., Motsinger-Reif, A. A., & Reif, D. M. (2024). Guided optimization of ToxPi model weights using a Semi-Automated approach. COMPUTATIONAL TOXICOLOGY, 29. https://doi.org/10.1016/j.comtox.2023.100294

Gonzalez, R. D., Small, G. W., Green, A. J., Akhtari, F. S., Motsinger-Reif, A. A., Quintanilha, J. C. F., … Wiltshire, T. (2023). MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients. PHARMACEUTICALS, 16(5). https://doi.org/10.3390/ph16050757

Small, G. W., Akhtari, F. S., Green, A. J., Havener, T. M., Sikes, M., Quintanhila, J., … Wiltshire, T. (2023). Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy. CELLS, 12(12). https://doi.org/10.3390/cells12121574

Gonzalez, R. D., Small, G. W., Green, A. J., Akhtari, F. S., Havener, T. M., Quintanilha, J. C. F., … Wiltshire, T. (2023). RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients. PHARMACEUTICALS, 16(5). https://doi.org/10.3390/ph16050726

Lloyd, D. T., Skinner, H. G., Maguire, R., Murphy, S. K., Motsinger-Reif, A. A., Hoyo, C., & House, J. S. (2022). Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18). https://doi.org/10.3390/ijms231810450

Wolkin, A., Collier, S., House, J. S., Reif, D., Motsinger-Reif, A., Duca, L., & Sharpe, J. D. (2022). Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response. Public Health Reports, 137(4), 803–812. https://doi.org/10.1177/00333549221090262

Mandal, M., Levy, J., Ives, C., Hwang, S., Zhou, Y.-H., Motsinger-Reif, A., … Edwards, S. (2022). Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study. FRONTIERS IN PHARMACOLOGY, 13. https://doi.org/10.3389/fphar.2022.883433

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). Genomic map of candidate human imprint control regions: the imprintome. EPIGENETICS, Vol. 6. https://doi.org/10.1080/15592294.2022.2091815

Lewis, A. M., Jr., Thomas, R., Breen, M., Peden, K., Teferedegne, B., Foseh, G., … Lewis, G. (2022). The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells. PLOS ONE, 17(10). https://doi.org/10.1371/journal.pone.0275394

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4. https://doi.org/10.1038/s41370-022-00433-w

McDonough, C. W., Warren, H. R., Jack, J. R., Motsinger‐Reif, A. A., Armstrong, N. D., Bis, J. C., … Cooper‐DeHoff, R. M. (2021). Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies. Clinical Pharmacology & Therapeutics, 110(3), 723–732. https://doi.org/10.1002/cpt.2355

Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). Extending the lymphoblastoid cell line model for drug combination pharmacogenomics. PHARMACOGENOMICS, Vol. 22. https://doi.org/10.2217/pgs-2020-0160

Akhtari, F. S., Green, A. J., Small, G. W., Havener, T. M., House, J. S., Roell, K. R., … Motsinger-Reif, A. A. (2021). High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs. PLOS GENETICS, 17(8). https://doi.org/10.1371/journal.pgen.1009732

Weeks, J. M., Motsinger-Reif, A. A., & Reems, M. M. (2021). In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques. JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 25–31. https://doi.org/10.1111/vec.13020

Jiang, T., Li, Y., & Motsinger-Reif, A. A. (2021). Knockoff boosted tree for model-free variable selection. BIOINFORMATICS, 37(7), 976–983. https://doi.org/10.1093/bioinformatics/btaa770

Ma, J., & Motsinger-Reif, A. (2021). Prediction of synergistic drug combinations using PCA-initialized deep learning. BIODATA MINING, 14(1). https://doi.org/10.1186/s13040-021-00278-3

Akhtari, F. S., Havener, T. M., Hertz, D. L., Ash, J., Larson, A., Carey, L. A., … Motsinger-Reif, A. A. (2021). Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines. PHARMACOGENETICS AND GENOMICS, 31(2), 48–52. https://doi.org/10.1097/FPC.0000000000000419

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January). The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. https://doi.org/10.1289/EHP8690

Wise, C. F., Hammel, S. C., Herkert, N., Ma, J., Motsinger-Reif, A., Stapleton, H. M., & Breen, M. (2020). Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419. https://doi.org/10.1021/acs.est.9b06605

Craun, K., Ekena, J., Sacco, J., Jiang, T., Motsinger-Reif, A., & Trepanier, L. A. (2020). Genetic and environmental risk for lymphoma in boxer dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 2068–2077. https://doi.org/10.1111/jvim.15849

House, J. S., Bouzos, E., Fahy, K. M., Francisco, V. M., Lloyd, D. T., Wright, F. A., … Wheeler, K. E. (2020). Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells. SMALL, 16(21). https://doi.org/10.1002/smll.202000299

Ma, J., Bair, E., & Motsinger-Reif, A. (2020). Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm. DOSE-RESPONSE, 18(2). https://doi.org/10.1177/1559325820926734

Lynch, A. M., Ruterbories, L., Jack, J., Motsinger-Reif, A. A., & Hanel, R. (2020). The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood. JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425. https://doi.org/10.1111/vec.12979

Crestani, E., Harb, H., Charbonnier, L.-M., Leirer, J., Motsinger-Reif, A., Rachid, R., … Chatila, T. A. (2020). Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(3), 897–906. https://doi.org/10.1016/j.jaci.2019.10.014

Tang, Y., Lenzini, P. A., Pop-Busui, R., Ray, P. R., Campbell, H., Perkins, B. A., … Doria, A. (2019). A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies. DIABETES, 68(8), 1649–1662. https://doi.org/10.2337/db19-0109

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., … Kaddurah-Daouk, R. (2019). Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome. Alzheimer's & Dementia, 15(1), 76–92. https://doi.org/10.1016/J.JALZ.2018.07.217

St John-Williams, L., Mahmoudiandehkordi, S., Arnold, M., Massaro, T., Blach, C., Kastenmueller, G., … Kaddurah-Daouk, R. (2019, October 17). Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts. SCIENTIFIC DATA, Vol. 6. https://doi.org/10.1038/s41597-019-0181-8

Ash, J. R., Kuenemann, M. A., Rotroff, D., Motsinger-Reif, A., & Fourches, D. (2019). Cheminformatics approach to exploring and modeling trait-associated metabolite profiles. JOURNAL OF CHEMINFORMATICS, 11. https://doi.org/10.1186/s13321-019-0366-3

Menden, M. P., Wang, D., Mason, M. J., Szalai, B., Bulusu, K. C., Guan, Y., … Zucknick, M. (2019). Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. NATURE COMMUNICATIONS, 10. https://doi.org/10.1038/s41467-019-09799-2

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C.-J., Vives-Usano, M., Rezwan, F. I., … London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. EPIGENOMICS, 11(13), 1487–1500. https://doi.org/10.2217/epi-2019-0066

Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. CHROMOSOME RESEARCH, 27(3), 179–202. https://doi.org/10.1007/s10577-019-09606-0

West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M. A., Chang, S.-M., Wu, M. C., … Tzeng, J.-Y. (2019). Identifying individual risk rare variants using protein structure guided local tests (POINT). PLOS COMPUTATIONAL BIOLOGY, 15(2). https://doi.org/10.1371/journal.pcbi.1006722

Fox, P. R., Keene, B. W., Lamb, K., Schober, K. E., Chetboul, V., Fuentes, V. L., … Ohara, V. Y. T. (2019). Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy. JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2572–2586. https://doi.org/10.1111/jvim.15609

Roell, K. R., Havener, T. M., Reif, D. M., Jack, J., McLeod, H. L., Wiltshire, T., & Motsinger-Reif, A. A. (2019). Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines. FRONTIERS IN GENETICS, 10. https://doi.org/10.3389/fgene.2019.00829

Crestani, E., Leirer, J., Motsinger-Reif, A., Phipatanakul, W., Kaddurah-Daouk, R., & Chatila, T. A. (2019, February). Untargeted Metabolomic Profiling Identifies Disease-Specific Pathways in Food Allergy and Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 143, pp. AB255–AB255. https://doi.org/10.1016/j.jaci.2018.12.778

Jack, J., Small, G. W., Brown, C. C., Havener, T. M., McLeod, H. L., Motsinger-Reif, A. A., & Richards, K. L. (2018). Gene expression and linkage analysis implicate as a mediator of rituximab resistance. PHARMACOGENOMICS JOURNAL, 18(3), 467–473. https://doi.org/10.1038/tpj.2017.41

Mathur, R., Rotroff, D., Ma, J., Shojaie, A., & Motsinger-Reif, A. (2018). Gene set analysis methods: A systematic comparison. Biodata Mining, 11.

Morieri, M. L., Gao, H., Pigeyre, M., Shah, H. S., Sjaarda, J., Mendonca, C., … Doria, A. (2018). Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial. DIABETES CARE, 41(11), 2404–2413. https://doi.org/10.2337/dc18-0709

Rotroff, D. M., Yee, S. W., Zhou, K. X., Marvel, S. W., Shah, H. S., Jack, J. R., … Wagner, M. J. (2018). Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes. Diabetes, 67(7), 1428–1440.

Fox, P. R., Keene, B. W., Lamb, K., Schober, K. A., Chetboul, V., Fuentes, V. L., … Ware, W. A. (2018). International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study. Journal of Veterinary Internal Medicine, 32(3), 930–943.

Shah, H. S., Morieri, M. L., Marcovina, S. M., Sigal, R. J., Gerstein, H. C., Wagner, M. J., … Doria, A. (2018). Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD. DIABETES CARE, 41(2), 348–355. https://doi.org/10.2337/dc17-1638

Chen, J., Akhtari, F. S., Wagner, M. J., Suzuki, O., Wiltshire, T., Motsinger-Reif, A. A., & Dumond, J. B. (2018). Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging? CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 226–236. https://doi.org/10.1111/cts.12525

Kaddurah-Daouk, R., Hankemeier, T., Scholl, E. H., Baillie, R., Harms, A., Stage, C., … Rasmussen, H. B. (2018). Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(8), 525–533. https://doi.org/10.1002/psp4.12309

Shahin, M. H., Gong, Y., Frye, R. F., Rotroff, D. M., Beitelshees, A. L., Baillie, R. A., … Johnson, J. A. (2018). Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1). https://doi.org/10.1161/jaha.117.006656

Akhtari, F. S., Havener, T. M., Fukudo, M., Jack, J. R., McLeod, H. L., Wiltshire, T., & Motsinger-Reif, A. A. (2018). The influence of Neanderthal alleles on cytotoxic response. PEERJ, 6. https://doi.org/10.7717/peerj.5691

Roell, K. R., Reif, D. M., & Motsinger-Reif, A. A. (2017). [Review of An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines]. Frontiers in Pharmacology, 8.

Teferedegne, B., Rotroff, D. M., Macauley, J., Foseh, G., Lewis, G., Motsinger-Rief, A., & Lewis, A. M., Jr. (2017, October 4). Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells. VACCINE, Vol. 35, pp. 5503–5509. https://doi.org/10.1016/j.vaccine.2017.04.004

Mochizuki, H., Motsinger-Reif, A., Bettini, C., Moroff, S., & Breen, M. (2017). Association of breed and histopathological grade in canine mast cell tumours. VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839. https://doi.org/10.1111/vco.12225

Marvel, S. W., Rotroff, D. M., Wagner, M. J., Buse, J. B., Havener, T. M., McLeod, H. L., & Motsinger-Reif, A. A. (2017). Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial. PeerJ, 5.

Rotroff, D. M., Marvel, S. W., Jack, J. R., Havener, T. M., Doria, A., Shah, H. S., … Motsinger-Reif, A. A. (2017). Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial. Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.

St John-Williams, L., Blach, C., Toledo, J. B., Rotroff, D. M., Kim, S., Klavins, K., … Saykin, A. J. (2017). Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. Scientific Data, 4.

Nho, K., Dehkordi, S. M., Motsinger-Reif, A., Baillie, R. A., Bhattacharyya, S., Tenenbaum, J. D., … Kaddurah-Daouk, R. F. (2017). GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE. Alzheimer's & Dementia, 13(7), P543–P544. https://doi.org/10.1016/J.JALZ.2017.07.131

Rotroff, D. M., Pijut, S. S., Marvel, S. W., Jack, J. R., Havener, T. M., Pujol, A., … Motsinger‐Reif, A. A. (2017). Genetic Variants in
            HSD17B3
            ,
            SMAD3
            , and
            IPO11
            Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. Clinical Pharmacology & Therapeutics, 103(4), 712–721. https://doi.org/10.1002/CPT.798

Toledo, J. B., Arnold, M., Kastenmuller, G., Chang, R., Baillie, R. A., Han, X. L., … Motsinger-Reif, A. (2017). Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers & Dementia, 13(9), 965–984.

Toledo, J. B., Arnold, M., Kastenmüller, G., Chang, R., Baillie, R. A., Han, X., … Kaddurah-Daouk, R. (2017). Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimer's & Dementia, 13(9), 965–984. https://doi.org/10.1016/J.JALZ.2017.01.020

St John-Williams, L., Blach, C., Toledo, J. B., Rotroff, D. M., Kim, S., Klavins, K., … Kaddurah-Daouk, R. (2017). Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. Scientific Data, 4(1). https://doi.org/10.1038/SDATA.2017.140

Carter, J. E., Motsinger-Reif, A. A., Krug, W. V., & Keene, B. W. (2017). The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs. JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213. https://doi.org/10.5326/jaaha-ms-6512

Nguyen, T. V., Reuter, J. M., Gaikwad, N. W., Rotroff, D. M., Kucera, H. R., Motsinger-Reif, A., … Schmidt, P. J. (2017). The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback. Translational Psychiatry, 7(8), e1193–e1193. https://doi.org/10.1038/TP.2017.146

McLaughlin, C. M., Marks, S. L., Dorman, D. C., Motsinger-Reif, A., & Hanel, R. M. (2017). Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs. JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81. https://doi.org/10.1111/vec.12526

Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Basak, N., … Kasiulevicius, V. (2016). A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics. PLoS One, 11(9).

Jackson, J. N., Long, K. M., He, Y., Motsinger-Reif, A. A., McLeod, H. L., & Jack, J. (2016). A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure. PHARMACOGENETICS AND GENOMICS, 26(4), 147–153. https://doi.org/10.1097/fpc.0000000000000200

Shahin, M. H., Gong, Y., McDonough, C. W., Rotroff, D. M., Beitelshees, A. L., Garrett, T. J., … Kaddurah-Daouk, R. (2016). A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration. Hypertension, 68(3), 621-.

Irvin, M. R., Rotroff, D. M., Aslibekyan, S., Zhi, D. G., Hidalgo, B., Motsinger-Reif, A., … Rotter, J. I. (2016). A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies. Pharmacogenetics and Genomics, 26(7), 324–333.

He, Y. J., Winham, S. J., Hoskins, J. M., Glass, S., Paul, J., Brown, R., … McLeod, H. L. (2016). Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial. PHARMACOGENOMICS JOURNAL, 16(3), 243–248. https://doi.org/10.1038/tpj.2015.52

Roode, S. C., Rotroff, D., Richards, K. L., Moore, P., Motsinger-Reif, A., Okamura, Y., … Breen, M. (2016). Comprehensive genomic characterization of five canine lymphoid tumor cell lines. BMC Veterinary Research, 12.

Chialvo, C. H. S., Che, R., Reif, D., Motsinger-Reif, A., & Reed, L. K. (2016). Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes. METABOLOMICS, 12(11). https://doi.org/10.1007/s11306-016-1117-3

Rotroff, D. M., & Motsinger-Reif, A. A. (2016). [Review of Embracing integrative multiomics approaches]. International Journal of Genomics.

Kim, S., Toledo, J. B., Nho, K., Risacher, S. L., Shen, L., Thompson, J. W., … Metabolomics Consortium, A. D. (2016). GENETIC INFLUENCE ON LEVELS OF TARGETED METABOLITES ASSOCIATED WITH ALZHEIMER’S DISEASE. Alzheimer's & Dementia, 12(7), P164–P165. https://doi.org/10.1016/J.JALZ.2016.06.276

Shah, H. S., Gao, H., Morieri, M. L., Skupien, J., Marvel, S., Pare, G., … Kraft, P. (2016). Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial. Diabetes Care, 39(11), 1915–1924.

Reinhart, J. M., Motsinger-Reif, A., Dickey, A., Yale, S., & Trepanier, L. A. (2016). Genome-wide association study in immunocompetent patients with delayed hypersensitivity to sulfonamide antimicrobials. PLoS One, 11(6).

Kling, M. A., Goodenowe, D. B., Toledo, J. B., Senanayake, V., Baillie, R. A., Lucas, J. E., … Kaddurah-Daouk, R. F. (2016). INDICES OF PLASMALOGEN BIOSYNTHESIS IN ADNI-1 BASELINE SERUM SAMPLES: ASSOCIATION WITH PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT. Alzheimer's & Dementia, 12(7), P879–P880. https://doi.org/10.1016/J.JALZ.2016.06.1817

Graham, H. T., Rotroff, D. M., Marvel, S. W., Buse, J. B., Havener, T. M., Wilson, A. G., … Motsinger-Reif, A. A. (2016). Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response. Frontiers in Genetics, 7.

Rotroff, D. M., Joubert, B. R., Marvel, S. W., Haberg, S. E., Wu, M. C., Nilsen, R. M., … Motsinger-Reif, A. (2016). Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero. BMC Genomics, 17.

Rotroff, D. M., Corum, D. G., Motsinger-Reif, A., Fiehn, O., Bottrel, N., Drevets, W. C., … Kaddurah-Daouk, R. (2016). Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. Translational Psychiatry, 6(9), e894–e894. https://doi.org/10.1038/TP.2016.145

Rotroff, D. M., Oki, N. O., Liang, X. M., Yee, S. W., Stocker, S. L., Corum, D. G., … Kaddurah-Daouk, R. (2016). Pharmacometabolomic assessment of metformin in non-diabetic, African Americans. Frontiers in Pharmacology, 7.

Toledo, J. B., Thompson, J. W., St. John Williams, L., Tenenbaum, J., Han, X., Baillie, R. A., … Kaddurah-Daouk, R. F. (2016). THE ALZHEIMER’S METABOLOME: RELATIONSHIP TO PATHOLOGICAL MARKERS AND COGNITIVE DECLINE IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI). Alzheimer's & Dementia, 12(7), P164. https://doi.org/10.1016/J.JALZ.2016.06.275

Friedenberg, S. G., Chdid, L., Keene, B., Sherry, B., Motsinger-Reif, A., & Meurs, K. M. (2016). Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy. AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699. https://doi.org/10.2460/ajvr.77.7.693

Zhou, K., Yee, S. W., Seiser, E. L., van Leeuwen, N., Tavendale, R., Bennett, A. J., … Pearson, E. R. (2016). Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nature Genetics, 48(9), 1055–1059. https://doi.org/10.1038/NG.3632

Zhou, K. X., Yee, S. W., Seiser, E. L., Leeuwen, N., Tavendalel, R., Bennett, A. J., … Chen, L. (2016). Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nature Genetics, 48(9), 1055-.

Cobb, J., Eckhart, A., Motsinger-Reif, A., Carr, B., Groop, L., & Ferrannini, E. (2016). alpha-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance. DIABETES CARE, 39(6), 988–995. https://doi.org/10.2337/dc15-2752

He, Y., Hoskins, J. M., Clark, S., Campbell, N. H., Wagner, K., Motsinger-Reif, A. A., & McLeod, H. L. (2015). Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups. PHARMACOGENOMICS, 16(8), 817–824. https://doi.org/10.2217/pgs.15.41

Beam, A. L., Motsinger-Reif, A. A., & Doyle, J. (2015). An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics. Biodata Mining, 8.

Shapiro, S. G., Raghunath, S., Williams, C., Motsinger-Reif, A. A., Cullen, J. M., Liu, T., … Breen, M. (2015). Canine urothelial carcinoma: genomically aberrant and comparatively relevant. Chromosome Research, 23(2), 311–331. https://doi.org/10.1007/s10577-015-9471-y

Poorman, K., Borst, L., Moroff, S., Roy, S., Labelle, P., Motsinger-Reif, A., & Breen, M. (2015). Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization. CHROMOSOME RESEARCH, 23(2), 171–186. https://doi.org/10.1007/s10577-014-9444-6

Jack, J., Havener, T. M., McLeod, H. L., Motsinger-Reif, A. A., & Foster, M. (2015). Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations. PHARMACOGENOMICS, 16(13), 1451–1463. https://doi.org/10.2217/pgs.15.85

Roode, S. C., Rotroff, D., Avery, A. C., Suter, S. E., Bienzle, D., Schiffman, J. D., … Breen, M. (2015). Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation. Chromosome Research, 23(4), 681–708. https://doi.org/10.1007/s10577-015-9475-7

Knazovicky, D., Tomas, A., Motsinger-Reif, A., & Lascelles, B. D. X. (2015). Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain. PeerJ, 3.

Rotroff, D. M., Shahin, M. H., Gurley, S. B., Zhu, H., Motsinger-Reif, A., Meisner, M., … Kaddurah-Daouk, R. (2015). Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes. CPT: Pharmacometrics & Systems Pharmacology, 4(11), 669–679. https://doi.org/10.1002/PSP4.12017

Abdo, N., Xia, M., Brown, C. C., Kosyk, O., Huang, R., Sakamuru, S., … Wright, F. A. (2015). Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study. ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466. https://doi.org/10.1289/ehp.1408775

Hecht, E. S., Scholl, E. H., Walker, S. H., Taylor, A. D., Cliby, W. A., Motsinger-Reif, A. A., & Muddiman, D. C. (2015). Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples. JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401. https://doi.org/10.1021/acs.jproteome.5b00703

LeVine, D. N., Birkenheuer, A. J., Brooks, M. B., Nordone, S. K., Bellinger, D. A., Jones, S. L., … Key, N. S. (2014). A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs? British Journal of Haematology, 167(1), 110–120. https://doi.org/10.1111/bjh.13005

Che, R. L., Jack, J. R., Motsinger-Reif, A. A., & Brown, C. C. (2014). An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use. Biodata Mining, 7.

Beam, A. L., Motsinger-Reif, A., & Doyle, J. (2014). Bayesian neural networks for detecting epistasis in genetic association studies. BMC Bioinformatics, 15.

Agler, C., Nielsen, D. M., Urkasemsin, G., Singleton, A., Tonomura, N., Sigurdsson, S., … Harris, T. (2014). Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24. PLoS Genetics, 10(2).

Bucknoff, M. C., Hanel, R. M., Marks, S. L., Motsinger-Reif, A. A., & Suter, S. E. (2014). Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation. AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432. https://doi.org/10.2460/ajvr.75.5.425

Hertz, D. L., Roy, S., Jack, J., Motsinger-Reif, A. A., Drobish, A., Clark, L. S., … McLeod, H. L. (2014). Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy. BREAST CANCER RESEARCH AND TREATMENT, 145(1), 245–254. https://doi.org/10.1007/s10549-014-2910-1

Brown, C. C., Havener, T. M., Medina, M. W., Jack, J. R., Krauss, R. M., McLeod, H. L., & Motsinger-Reif, A. A. (2014). Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines. PHARMACOGENOMICS, 15(2), 137–146. https://doi.org/10.2217/pgs.13.213

Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. CHROMOSOME RESEARCH, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z

Jack, J., Rotroff, D., & Motsinger-Reif, A. (2014). Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model. CURRENT MOLECULAR MEDICINE, 14(7), 833–840. https://doi.org/10.2174/1566524014666140811113946

Gonzalez, L. M., Fogle, C. A., Baker, W. T., Hughes, F. E., Law, J. M., Motsinger-Reif, A. A., & Blikslager, A. T. (2014). Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013. Equine Veterinary Journal, 47(3), 279–284. https://doi.org/10.1111/evj.12273

Rotroff, D., Jack, J., Campbell, N., Clark, S., & Motsinger-Reif, A. A. (2014). PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles. Biodata Mining, 7.

Ginn, J., Sacco, J., Wong, Y. Y., Motsinger-Reif, A., Chun, R., & Trepanier, L. A. (2014). Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs. VETERINARY AND COMPARATIVE ONCOLOGY, 12(3), 227–236. https://doi.org/10.1111/vco.12000

Lockhart, L. E., Motsinger-Reif, A. A., Simpson, W. M., & Posner, L. P. (2014). Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure. Veterinary Anaesthesia and Analgesia, 41(1), 48–53. https://doi.org/10.1111/vaa.12077

Tomas, A., Marcellin-Little, D. J., Roe, S. C., Motsinger-Reif, A., & Lascelles, B. D. X. (2014). Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds. VETERINARY SURGERY, 43(5), 542–548. https://doi.org/10.1111/j.1532-950x.2014.12160.x

Jack, J. R., Motsinger-Reif, A. A., Koutros, S., Alavanja, M. C., Beane Freeman, L. E., & Hoppin, J. A. (2014). Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study. Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195. https://doi.org/10.1158/1055-9965.epi-14-0276

Chen, H.-W., Small, G. W., Motsinger-Reif, A., Suter, S. E., & Richards, K. L. (2014). VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival. Veterinary Immunology and Immunopathology, 157(3-4), 125–130. https://doi.org/10.1016/j.vetimm.2013.10.020

Posner, L. P., Bailey, K. M., Richardson, E. Y., Motsinger-Reif, A. A., & Harms, C. A. (2013). Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion. Journal of Zoo and Wildlife Medicine, 44(4), 965–971. https://doi.org/10.1638/2013-0090r.1

Kaddurah-Daouk, R., Zhu, H., Sharma, S., Bogdanov, M., Rozen, S. G., Matson, W., … Arnold, S. E. (2013). Alterations in metabolic pathways and networks in Alzheimer’s disease. Translational Psychiatry, 3(4), e244–e244. https://doi.org/10.1038/TP.2013.18

Hertz, D. L., Roy, S., Motsinger-Reif, A. A., Drobish, A., Clark, L. S., McLeod, H. L., … Dees, E. C. (2013). CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel. ANNALS OF ONCOLOGY, 24(6), 1472–1478. https://doi.org/10.1093/annonc/mdt018

Guo, L., Tsai, S. Q., Hardison, N. E., James, A. H., Motsinger-Reif, A. A., Thames, B., … Piedrahita, J. A. (2013). Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas. Placenta, 34(7), 599–605. https://doi.org/10.1016/j.placenta.2013.04.007

Richards, K. L., Motsinger-Reif, A. A., Chen, H.-W., Fedoriw, Y., Fan, C., Nielsen, D. M., … Suter, S. E. (2013). Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL. Cancer Research, 73(16), 5029–5039. https://doi.org/10.1158/0008-5472.can-12-3546

Su, Y. H., Nielsen, D., Zhu, L., Richards, K., Suter, S., Breen, M., … Osborne, J. (2013). Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data. Human Genomics, 7.

Motsinger-Reif, A. A., Jorgenson, E., Relling, M. V., Kroetz, D. L., Weinshilboum, R., Cox, N. J., & Roden, D. M. (2013). Genome-wide association studies in pharmacogenomics: Successes and lessons. Pharmacogenetics and Genomics, 23(8), 383–394.

Jones, S., & Motsinger-Reif, A. (2013). Interview A discussion on genome-wide associations in pharmacogenomics. Pharmacogenomics, 14(4), 361–363.

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine. PHARMACOGENOMICS, Vol. 14, pp. 1929–1931. https://doi.org/10.2217/pgs.13.178

Dai, H. Y., Charnigo, R. J., Becker, M. L., Leeder, J. S., & Motsinger-Reif, A. A. (2013). Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction. Biodata Mining, 6.

Brown, C. C., Havener, T. M., Medina, M. W., Auman, J. T., Mangravite, L. M., Krauss, R. M., … Motsinger-Reif, A. A. (2012). A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT. PHARMACOGENETICS AND GENOMICS, 22(11), 796–802. https://doi.org/10.1097/fpc.0b013e3283589c50

Brown, C., Oki, N. O., Hariani, G., & Motsinger-Reif, A. A. (2012). A predictive model for Efavirenz dosing. Pharmacogenomics, 13(2), 137–138.

He, Y. J., Misher, A. D., Irvin, W., Motsinger-Reif, A., McLeod, H. L., & Hoskins, J. M. (2012). Assessing the utility of whole genome amplified DNA as a template for DMET Plus array. Clinical Chemistry and Laboratory Medicine, 50(8), 1329–1334.

Hertz, D. L., Motsinger-Reif, A. A., Drobish, A., Winham, S. J., McLeod, H. L., Carey, L. A., & Dees, E. C. (2012). CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel. BREAST CANCER RESEARCH AND TREATMENT, 134(1), 401–410. https://doi.org/10.1007/s10549-012-2054-0

Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). Comparison of venous sampling methods for thromboelastography in clinically normal dogs. AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870. https://doi.org/10.2460/ajvr.73.12.1864

Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs. AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601. https://doi.org/10.2460/ajvr.73.5.595

Funk-Keenan, J., Sacco, J., Wong, Y. Y., Rasmussen, S., Motsinger-Reif, A., & Trepanier, L. A. (2012). Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1126–1133. https://doi.org/10.1111/j.1939-1676.2012.00965.x

Sacco, J. C., Abouraya, M., Motsinger-Reif, A., Yale, S. H., McCarty, C. A., & Trepanier, L. A. (2012). Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity. PHARMACOGENETICS AND GENOMICS, 22(10), 733–740. https://doi.org/10.1097/fpc.0b013e328357a735

Che, R., Motsinger-Reif, A. A., & Brown, C. C. (2012). Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies. Genetic Epidemiology, n/a-n/a. https://doi.org/10.1002/gepi.21671

Che, R. L., Motsinger-Reif, A. A., & Brown, C. C. (2012). Loss of power in two-stage residual-outcome regression analysis in genetic association studies.

Brown, C. C., Havener, T. M., Medina, M. W., Krauss, R. M., McLeod, H. L., & Motsinger-Reif, A. A. (2012). Multivariate methods and software for association mapping in dose-response genome-wide association studies. Biodata Mining, 5.

Ravel, J., Gajer, P., Fu, L., Mauck, C. K., Koenig, S. S. K., Sakamoto, J., … Zeichner, S. L. (2012). Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota. MBIO, 3(6). https://doi.org/10.1128/mbio.00370-12

Winham, S., Wang, C., & Motsinger-Reif, A. A. (2011). A Comparison of Multifactor Dimensionality Reduction and L-1-Penalized Regression to Identify Gene-Gene Interactions in Genetic Association Studies. STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 10(1). https://doi.org/10.2202/1544-6115.1613

Angstadt, A. Y., Motsinger-Reif, A., Thomas, R., Kisseberth, W. C., Couto, C. G., Duval, D. L., … Breen, M. (2011). Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart. GENES CHROMOSOMES & CANCER, 50(11), 859–874. https://doi.org/10.1002/gcc.20908

Watson, V. G., Hardison, N. E., Harris, T., Motsinger-Reif, A., & McLeod, H. L. (2011). Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines. MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845. https://doi.org/10.1158/1535-7163.mct-10-0872

Watson, V. G., Motsinger-Reif, A., Hardison, N. E., Peters, E. J., Havener, T. M., Everitt, L., … McLeod, H. L. (2011). Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees. PLoS One, 6(5).

Cohen, M. G., Rossi, J. S., Garbarino, J., Bowling, R., Motsinger-Reif, A. A., Schuler, C., … Gabriel, D. (2011). Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel. THROMBOSIS RESEARCH, 128(4), 335–340. https://doi.org/10.1016/j.thromres.2011.04.023

Thomas, F., Motsinger-Reif, A. A., Hoskins, J. M., Dvorak, A., Roy, S., Alyasiri, A., … McLeod, H. L. (2011). Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer. British Journal of Cancer, 105(11), 1654–1662. https://doi.org/10.1038/BJC.2011.442

Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11.

Beam, A. L., & Motsinger-Reif, A. A. (2011). Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation. Dose-Response, 9(3), 387–409.

Peters, E. J., Motsinger-Reif, A., Havener, T. M., Everitt, L., Hardison, N. E., Watson, V. G., … McLeod, H. L. (2011). Pharmacogenomic characterization of US FDA-approved cytotoxic drugs. PHARMACOGENOMICS, 12(10), 1407–1415. https://doi.org/10.2217/pgs.11.92

Asher, G. N., Motsinger-Reif, A. A., Jonas, D. E., & Viera, A. J. (2011). Quality of reporting on randomised controlled trials of auriculotherapy for pain. ACUPUNCTURE IN MEDICINE, 29(2), 122–126. https://doi.org/10.1136/aim.2010.003475

Thomas, R., Seiser, E. L., Motsinger-Reif, A., Borst, L., Valli, V. E., Kelley, K., … Breen, M. (2011). Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leukemia & Lymphoma, 52(7), 1321–1335. https://doi.org/10.3109/10428194.2011.559802

Gamble, K. L., Motsinger-Reif, A. A., Hida, A., Borsetti, H. M., Servick, S. V., Ciarleglio, C. M., … Johnson, C. H. (2011). Shift work in nurses: Contribution of phenotypes and genotypes to adaptation. PLoS One, 6(4).

Winham, S. J., & Motsinger-Reif, A. A. (2011). The Effect of Retrospective Sampling on Estimates of Prediction Error for Multifactor Dimensionality Reduction. Annals of Human Genetics, 75, 46–61.

Tsai, S., Hardison, N. E., James, A. H., Motsinger-Reif, A. A., Bischoff, S. R., Thames, B. H., & Piedrahita, J. A. (2011). Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. PLACENTA, 32(2), 175–182. https://doi.org/10.1016/j.placenta.2010.11.014

Winham, S. J., Slater, A. J., & Motsinger-Reif, A. A. (2010). A comparison of internal validation techniques for multifactor dimensionality reduction. BMC Bioinformatics, 11.

Asher, G. N., Jonas, D. E., Coeytaux, R. R., Reilly, A. C., Loh, Y. L., Motsinger-Reif, A. A., & Winham, S. J. (2010). [Review of Auriculotherapy for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 16(10), 1097–1108. https://doi.org/10.1089/acm.2009.0451

Motsinger-Reif, A. A. (2010, April 15). Discussion of a Genome-Wide Association Approach to Determine HIV-1 Set Point in African Americans. JOURNAL OF INFECTIOUS DISEASES, Vol. 201, pp. 1118–1120. https://doi.org/10.1086/651383

Ribaudo, H. J., Liu, H., Schwab, M., Schaeffeler, E., Eichelbaum, M., Motsinger-Reif, A. A., … Haas, D. W. (2010). Effect of CYP2B6, ABCB1, and CYP3A5 Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study. JOURNAL OF INFECTIOUS DISEASES, 202(5), 717–722. https://doi.org/10.1086/655470

Deodhar, S., & Motsinger-Reif, A. (2010). Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions. In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics (pp. 98–109). https://doi.org/10.1007/978-3-642-12211-8_9

Deodhar, S., & Motsinger-Reif, A. (2010). Grammatical evolution decision trees for detecting gene-gene interactions. Evolutionary computation, machine learning and data mining in bioinformatics, proceedings, 6023, 98–109.

Motsinger-Reif, A. A., Antas, P. R. Z., Oki, N. O., Levy, S., Holland, S. M., & Sterling, T. R. (2010). Polymorphisms in IL-1 beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. BMC Medical Genetics, 11.

Limdi, N. A., Wadelius, M., Cavallari, L., Eriksson, N., Crawford, D. C., Lee, M.-T. M., … Wagner, M. J. (2010). Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. BLOOD, 115(18), 3827–3834. https://doi.org/10.1182/blood-2009-12-255992

Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2009, December). A Comparison of Analytical Methods for Genetic Association Studies (vol 32, pg 767, 2008). GENETIC EPIDEMIOLOGY, Vol. 33, pp. 751–751. https://doi.org/10.1002/gepi.20420

Bischoff, S. R., Tsai, S., Hardison, N., Motsinger-Reif, A. A., Freking, B. A., Nonneman, D., … Piedrahita, J. A. (2009). Characterization of Conserved and Nonconserved Imprinted Genes in Swine. BIOLOGY OF REPRODUCTION, 81(5), 906–920. https://doi.org/10.1095/biolreprod.109.078139

Reif, D. M., Motsinger-Reif, A. A., McKinney, B. A., Rock, M. T., Crowe, J. E., Jr., & Moore, J. H. (2009). Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. GENES AND IMMUNITY, 10(2), 112–119. https://doi.org/10.1038/gene.2008.80

Tsai, S., Hardison, N., Bischoff, S., Thames, B., Jamessd, A., Motsinger-Reif, A., & Piedrahita, J. (2008). 262: Molecular signatures of preeclampsia in human term placentas. American Journal of Obstetrics and Gynecology, 199(6), S84. https://doi.org/10.1016/j.ajog.2008.09.290

Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2008). A Comparison of Analytical Methods for Genetic Association Studies. GENETIC EPIDEMIOLOGY, 32(8), 767–778. https://doi.org/10.1002/gepi.20345

Motsinger-Reif, A. A., Dudek, S. M., Hahn, L. W., & Ritchie, M. D. (2008). Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. GENETIC EPIDEMIOLOGY, 32(4), 325–340. https://doi.org/10.1002/gepi.20307

Reif, D. M., McKinney, B. A., Motsinger, A. A., Chanock, S. J., Edwards, K. M., Rock, M. T., … Crowe, Jr., J. E. (2008). Genetic Basis for Adverse Events after Smallpox Vaccination. The Journal of Infectious Diseases, 198(1), 16–22. https://doi.org/10.1086/588670

Hulgan, T., Tebas, P., Canter, J. A., Mulligan, K., Haas, D. W., Dubé, M., … Kallianpur, A. R. (2008). Hemochromatosis Gene Polymorphisms, Mitochondrial Haplogroups, and Peripheral Lipoatrophy during Antiretroviral Therapy. The Journal of Infectious Diseases, 197(6), 858–866. https://doi.org/10.1086/528697

Velez, D. R., White, B. C., Motsinger, A. A., Bush, W. S., Ritchie, M. D., Williams, S. M., & Moore, J. H. (2007). A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genetic Epidemiology, 31(4), 306–315. https://doi.org/10.1002/gepi.20211

Motsinger, A. A., Brassat, D., Caillier, S. J., Erlich, H. A., Walker, K., Steiner, L. L., … Ritchie, M. D. (2007). Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics, 8(1), 11–20. https://doi.org/10.1007/S10048-006-0058-9

Ritchie, M. D., Edwards, T. L., Fanelli, T. J., & Motsinger, A. A. (2007). Genetic heterogeneity is not as threatening as you might think. Genetic Epidemiology, 31(7), 797–800. https://doi.org/10.1002/gepi.20256

Ritchie, M. D., Motsinger, A. A., Bush, W. S., Coffey, C. S., & Moore, J. H. (2007). Genetic programming neural networks: A powerful bioinformatics tool for human genetics. Applied Soft Computing, 7(1), 471–479. https://doi.org/10.1016/j.asoc.2006.01.013

Canter, J. A., Summar, M. L., Smith, H. B., Rice, G. D., Hall, L. D., Ritchie, M. D., … Barr, F. E. (2007). Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: A validated genetic association study. Mitochondrion, 7(3), 204–210. https://doi.org/10.1016/j.mito.2006.11.001

Motsinger, A. A., Haas, D. W., Hulgan, T., & Ritchie, M. D. (2007). Human Genomic Association Studies: A Primer for the Infectious Diseases Specialist. The Journal of Infectious Diseases, 195(12), 1737–1744. https://doi.org/10.1086/518247

Darbar, D., Motsinger, A. A., Ritchie, M. D., Gainer, J. V., & Roden, D. M. (2007). Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm, 4(6), 743–749. https://doi.org/10.1016/j.hrthm.2007.02.006

Motsinger, A. A., Dudek, S. M., Hahn, L. W., & Ritchie, M. D. (2006). Comparison of Neural Network Optimization Approaches for Studies of Human Genetics. In F. Rothlauf (Ed.), Applications of Evolutionary Computing. EvoWorkshops 2006 (pp. 103–114). https://doi.org/10.1007/11732242_10

Ritchie, M. D., Haas, D. W., Motsinger, A. A., Donahue, J. P., Erdem, H., Raffanti, S., … Sterling, T. R. (2006). Drug Transporter and Metabolizing Enzyme Gene Variants and Nonnucleoside Reverse-Transcriptase Inhibitor Hepatotoxicity. Clinical Infectious Diseases, 43(6), 779–782. https://doi.org/10.1086/507101

Haas, D. W., Geraghty, D. E., Andersen, J., Mar, J., Motsinger, A. A., D’Aquila, R. T., … Landay, A. (2006). Immunogenetics of CD4 Lymphocyte Count Recovery during Antiretroviral Therapy: An AIDS Clinical Trials Group Study. The Journal of Infectious Diseases, 194(8), 1098–1107. https://doi.org/10.1086/507313

Brassat, D., Motsinger, A. A., Caillier, S. J., Erlich, H. A., Walker, K., Steiner, L. L., … Ritchie, M. D. (2006). Multifactor dimensionality reduction reveals gene–gene interactions associated with multiple sclerosis susceptibility in African Americans. Genes & Immunity, 7(4), 310–315. https://doi.org/10.1038/sj.gene.6364299

Motsinger, A. A., & Ritchie, M. D. (2006). The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genetic Epidemiology, 30(6), 546–555. https://doi.org/10.1002/gepi.20166

Bush, W. S., Motsinger, A. A., Dudek, S. M., & Ritchie, M. D. (2005). Can Neural Network Constraints in GP Provide Power to Detect Genes Associated with Human Disease? In F. Rothlauf (Ed.), Applications of Evolutionary Computing. EvoWorkshops 2005 (pp. 44–53). https://doi.org/10.1007/978-3-540-32003-6_5